Effects of chronic unilateral internal pudendal arterial occlusion on reactivity of isolated corpus cavernosum strips from rabbits

European Journal of Pharmacology

Volumn 367, Issue 1, 1999, Pages 73-79

  Utkan, Tijen ^a   Sarioglu, Yusuf ^b   Utkan, Nihat Zafer ^a   Kurnaz, Füsun ^b   Yildirim, Sahin ^b  

^a KOCAELI UNIVERSITY   (Turkey)

^b CUMHURIYET UNIVERSITY   (Turkey)

Author keywords

Contraction; Corpus cavernosum; Ischemia; Relaxation

Indexed keywords

CARBACHOL;

ANIMAL MODEL; ANIMAL TISSUE; ARTERY LIGATION; ARTERY OCCLUSION; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; HEMODYNAMICS; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ADENOSINE; ANIMALS; ARTERIAL OCCLUSIVE DISEASES; ARTERIES; CARBACHOL; CHRONIC DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ENZYME INHIBITORS; MALE; MUSCLE CONTRACTION; MUSCLE RELAXATION; NG-NITROARGININE METHYL ESTER; NITROPRUSSIDE; PAPAVERINE; PARASYMPATHOMIMETICS; PENIS; PHENYLEPHRINE; POTASSIUM CHLORIDE; RABBITS; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 0033044413     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00930-3     Document Type: Article

References (33)

1. Aboseif S.R., Breza J., Orvis B.R., Lue T.F., Tanagho E.A. Erectile response to acute and chronic occlusion of the internal pudendal and penile arteries. J. Urol. 141:1989;398-402.
2. Aboseif S.R., Wetteraurer U., Breza J., Benard F., Bosch R., Stief C.G., Lue T., Tanagho E.A. The effect of venous incompetence and arterial insufficiency on erectile function: an animal model. J. Urol. 144:1990;790-793.
3. Andersson P.O., Bloom S.R., Mellander S. Haemodynamics of pelvic nerve induced penile erection in the dog: possible mediation by vasoactive intestinal polypeptide. J. Physiol. Lond. 350:1984;209-224.
4. Andersson K.E., Holmquist F. Mechanisms for contraction and relaxation of human penile smooth muscle. Int. J. Impot. Res. 2:1990;209-225.
5. Azadzoi K.M., Goldstein I. Erectile dysfunction due to atherosclerotic vascular disease: the development of an animal model. J. Urol. 147:1992;1675-1681.
6. Azadzoi K.M., Siroky M.B., Goldstein I. Study of etiologic relationship of arterial atherosclerosis to corporal veno-occlusive dysfunction in the rabbit. J. Urol. 155:1996;1795-1800.
7. Azadzoi K.M., Park K., Andry C., Goldstein I., Siroky M.B. Relationship between cavernosal ischemia and corporal veno-occlusive dysfunction in an animal model. J. Urol. 157:1997;1011-1017.
8. Benson G.S., McConnell J., Lipshultz L.I., Corriere J.N. Jr., Wood J. Neuromorphology and neuropharmacology of the human penis: an in vitro study. J. Clin. Invest. 65:1980;506-513.
9. Bookstein J.J., Machado T., Rippon D. Production of penile veno-occlusive insufficiency by arterial occlusion in a canine model. J. Urol. 137:1987;1283-1286.
10. Burnett A.L., Lowenstein C.J., Bredt P.S., Chang T.S.K., Snyder S.H. Nitric oxide: a physiologic mediator of penile erection. Science. 257:1992;401-403.
11. Bush P.A., Aronson W.J., Buga G.M., Rajfer J., Ignarro L.J. Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum. J. Urol. 147:1992;1650-1655.
12. Christ G.J., Maayani S., Valcic M., Melman A. Pharmacological studies of human erectile tissue: characteristics of spontaneous contractions and alterations in alpha-adrenoceptor responsiveness with age and disease in isolated tissues. Brit. J. Pharmacol. 101:1990;375-381.
13. Christ G.J., Stone B.S., Melman A. Age-dependent alterations in the efficacy of phenylephrine-induced contractions in vascular smooth muscle isolated from the corpus cavernosum of impotent men. Can. J. Physiol. Pharmacol. 69:1991;909-913.
14. Diederichs W., Stief C.G., Lue T.F., Tanagho E.A. Norephrine involvement in penile detumescence. J. Urol. 143:1990;1264-1266.
15. Fournier G.R. Jr., Juenemann D.P., Lue T.F., Tanagho E.A. Mechanisms of venous occlusion during canine penile erection anatomic demonstration. J. Urol. 137:1987;163-167.
16. Hedlung H., Andersson K.E. Comparison of the responses to drugs acting on adrenoceptors and muscarinic receptors in human isolated corpus cavernosum and cavernous artery. J. Auton. Pharmacol. 5:1985;81-88.
17. Houttuin E., Hawatmeh I.S., Burns J.R., Gregory J.G. Surgical correction of erectile impotence due to vascular insufficiency in the dog. Cli. Res. 26:1978;93A-94A.
18. Ignarro L.J., Bush P.A., Buga G.M., Wood K.S., Fukuto J.M., Rajfer J. Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem. Biopyhs. Res. Commun. 170:1990;843-850.
19. Katz A.M. Endothelium-derived relaxing factor. J. Am. Coll. Cardiol. 12:1988;797-811.
20. Kedia K.R. Penile plethysmography useful in diagnosis of vasculogenic impotence. Urology. 22:1983;235-239.
21. Knispel H.H., Goessl C., Beckmann R. Basal and acetylcholine-stimulated nitric oxide formation mediates relaxation of rabbit cavernous smooth muscle. J. Urol. 146:1991;1429-1433.
22. Krane R.J., Goldstein I., Saenz de Tejada I. Impotence. N. Engl. J. Med. 321:1989;1648-1659.
23. Leriche R. De la resection du carrefour aortico-iliaque avec double sympatectmie lombaire pour thrombose arteritique de l'obliteration termino-aortique par arterite. Presse Medicale. 48:1940;601.
24. Pickard R.S., King P., Zar M.A., Powell P.H. Corpus cavernosal relaxation in impotent men. Br. J. Urol. 74:1994;485-491.
25. Rajfer J., Aronson W.J., Bush P.A., Dorey F.J., Ignarro L.J. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N. Engl. J. Med. 326:1992;90-94.
26. Rosen M.P., Greenfield A.J., Walker T.G., Grant P., Guben J.K., Dubrow J., Bettmann M.A., Goldstein I. Arteriogenic impotence: findings in 195 impotent men examined with selective internal pudendal angiograph. Radiology. 174:1990;1043-1048.
27. Saenz de Tejada I., Blanco R., Goldstein I., Azadzoi K., Delas Morenas A., Krane R.J., Cohen R.A. Cholinergic neurotransmission in human corpus cavernosum: I. Responses of isolated tissue. Am. J. Phsysiol. 254:1988;H459-H467.
28. Taub H.C., Lerner S.E., Melman A., Christ G.J. Relationship between contraction and relaxation in human and rabbit corpus cavernosum. Urology. 42:1993;698-704.
29. Trigo-Rocha F., Hsu G.L., Donatucci C.F., Lue T.F. The role of cyclic adenosine monophosphate, cyclic guanosine monophosphate, endothelium and nonadrenergic noncholinergic neurotransmission in canine penile erection. J. Urol. 149:1993;872-877.
30. Vanarsdalen K.N., Wein A.J., Levin R.M. The contractile and metabolic effects of acute ischemia on the rabbit urinary bladder. J. Urol. 130:1983;180-182.
31. Vardi Y., Siroky M.B. Hemodynamics of pelvic nerve induced erection in a canine model: II. Cavernosal inflow and occlusion. J. Urol. 149:1993;910-914.
32. Virag R. Is impotence an arterial disorder? A study of arterial risk factors in 440 impotent men. Lancet. 1(8422):1985;181-184.
33. Yildirim M.K., Yildirim S., Utkan T., Sarioglu Y., Yalman Y. Effects of castration on adrenergic, cholinergic and nonadrenergic noncholinergic responses of isolated corpus cavernosum from rabbit. Br. J. Urol. 79:1997;964-970.