Sexual dysfunction related to antihypertensive agents: Results from the animal model

International Journal of Impotence Research

Volumn 11, Issue 2, 1999, Pages 107-113

  Srilatha, B ^a   Adaikan, P G ^a   Arulkumaran, S ^a   Ng, S C ^a  

^a NATIONAL UNIVERSITY HOSPITAL   (Singapore)

Author keywords

Antihypertensive drugs; Cavernous nerve stimulation; Erectile dysfunction; Intracavernous pressure; Sexual behaviour

Indexed keywords

ANTIHYPERTENSIVE AGENT; CAPTOPRIL; CLONIDINE; PROPRANOLOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; ELECTROSTIMULATION; ERECTILE DYSFUNCTION; INTRAGASTRIC DRUG ADMINISTRATION; MALE; NERVE STIMULATION; NONHUMAN; PENIS ERECTION; PRESSURE; PRIORITY JOURNAL; RAT; SEXUAL DYSFUNCTION; SEXUAL FUNCTION; VASCULAR DISEASE;

EID: 0033044323     PISSN: 09559930     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijir.3900393     Document Type: Article

References (50)

1. Morley JE. Impotence. Am J Med 1986; 80: 897-905.
2. Huws R. Sexual Pharmacology-Antihypertensive Medication and Sexual Problems. Clarendon Press: Oxford, 1993; 146-158.
3. Weiss RJ. Effects of antihypertensive agents on sexual function: review. Am Fam Physician 1991; 44: 2075-2082.
4. Prisant ML et al. Sexual dysfunction with antihypertensive drugs. Arch Int Med 1994; 154: 730-736.
5. Krane RJ, Goldstein I. Tejada IS. Impotence. New Engl J Med 1989; 321: 1648-1659.
6. Chobanian AV, Alexander RW. Exacerbation of atherosclerosis by hypertension: potential mechanisms and clinical implications. Arch Int Med 1996; 156: 1952-1956.
7. Lip GYH. Exacerbation of atherosclerosis by hypertension: potential mechanisms and clinical implications. Arch Int Med 1997; 157: 1265-1266.
8. Middeke M et al. Normalization of lipid metabolism after withdrawal from antihypertensive long-term therapy with beta blockers and diuretics. Arterioscler 1990: 10: 145-147.
9. Ferro CJ, Webb DJ. Endothelial dysfunction and hypertension. Drugs 1997; 53 (Suppl. 1): S30-S41.
10. Bulpitt CJ, Dollery CT, Carne S. Changes in symptoms of hypertensive patients after referral to hospital clinic. Br Heart J 1976; 38: 121-128.
11. Bauer GE, Hunyor SN, Baker J, Marshall P. Clinical side effects during antihypertensive therapy: a placebo controlled double-blind study. Postgrad Med Comm (Special Report) 1981; 49-54.
12. Bansal S. Sexual dysfunction in hypertensive men: a critical review of literature. Hypertension 1988; 12: 1-10.
13. Hsueh WA. Sexual dysfunction with aging and systemic hypertension. Am J Cardiol 1988; 61: 18-23.
14. Rosen RC, Weiner DN. Cardiovascular disease and sleep-related erections. J Psychosom Res 1997 42: 517-530.
15. Warren SC, Warren SG. Propranolol and sexual impotence (letter). Ann Int Med 1977; 86: 112.
16. Abramowicz M. Drugs that cause sexual dysfunction. Med Lett Drugs Ther 1987; 29: 65-70.
17. 1A) receptor-mediated modulation of adenylate cyclase activity by pindolol and propranolol isomers. Biochem Pharmacol 1988; 37: 3429-3433.
18. Rosen RC, Kostis JB, Jekelis AW. Beta-blocker effects on sexual function in normal males. Arch Sex Behav 1988; 17: 241-255.
19. Melman A, Libin M, Tendler C. The effect of chronic alpha-methyldopa upon sexual function in the adult male rat. J Urol 1983; 129: 643-645.
20. Onesti G et al. Clonidine: a new antihypertensive agent. Am J Cardiol 1971; 28: 74-83.
21. Mroczek WJ, Davidov M, Finnerty FA. Prolonged treatment with clonidine: comparative antihypertensive effects alone and with a diuretic agent. Am J Cardiol 1972; 30: 536-541.
22. Croog SH et al. Sexual symptoms in hypertensive patients: a clinical trial of hypertensive medication. Arch Int Med 1988; 148: 788-794.
23. Abramowicz M. Drugs that cause sexual dysfunction: an update. Med Lett Drugs Ther 1992; 34: 73-78.
24. Pfaus JG. Homologies of animal and human sexual behaviours. Harm Behav 1996; 30: 187-200.
25. Janssen BJA, Oosting J, Tyssen CM, Struyker-Boudier HAJ. Time-dependent efficacy of antihypertensive agents in spontaneously hypertensive rats. Chronobiol Int 1993; 10: 420-434.
26. Waynforth WB, Flecknell PA. Experimental and Surgical Technique in the Rat-Specific Surgical Operations. Academic Press Limited: London 1992; pp 276.
27. McGill TE. Sexual behaviour in three inbred strains of mice. Behaviour 1962; 19: 341-350.
28. Martinez-Pineiro L et al. Rat model for the study of penile erection: pharmacologic and electrical-stimulation parameters. Eur Urol 1994; 25: 62-70.
29. Gray GD, Smith ER, Dorsa DM, Davidson JM. Sexual behaviour and testosterone in middle-aged male rats. Endocrinology 1981; 109: 1597.
30. Chen KK et al. Intracavernous pressure as an experimental index in a rat model for the evaluation of penile erection. J Urol 1992; 147: 1124-1128.
31. Due DL, Giguere GC, Plachetka JR. Postmarketing comparison of labetalol and propranolol in hypertensive patients. Clin Ther 1986; 8: 624-631.
32. Kligman EW, Higbee MD. Drug therapy for hypertension in the elderly. J Fam Prac 1989; 28: 81-87.
33. Rosen RC. Sexual dysfunction as an obstacle to compliance with antihypertensive therapy. Bl Press 1997; (Suppl 1): S47-S51.
34. Adaikan PG, Lau LC, Ng SC, Ratnam SS. Physio-pharmacology of human penile erection: autonomic/nitrergic neurotransmissions and receptors of the human corpus cavernosum. Asia Pac J Pharmacol 1991; 6: 213-227.
35. Cooke BA, Golding M, Dix CJ, Hunter MG. Catecholamine stimulation of testosterone production via cyclic AMP in mouse Leydig cells in monolayer culture. Mol Cell Endocrinol 1982; 27: 221-231.
36. Zvara P et al. Nitric oxide mediated erectile activity is a testosterone dependent event: a rat erection model. Int J Impot Res 1995; 7: 209-219.
37. Ferder L, Inserra F, Medina F. Safety aspects of long term antihypertensivetherapy (10 years) with clonidine. J Cardiovasc Pharmacol 1987; 10 (Suppl. 12): S104-S108.
38. Burris JF. The USA experience with the clonidine transdermal therapeutic system. Clin Auton Res 1993; 3: 391-396.
39. Webster J, Koch HF. Aspects of tolerability of centrally acting antihypertensive drugs. J Cardiovasc Pharmacol 1996; 27 (Suppl. 3): S49-S54.
40. Van-Zwieten PA. Centrally acting antihypertensives: a renaissance of interest. Mechanisms and haemodynamics. J Hypertens (Suppl 15(1) 1997; 15: S3-S8.
41. Clark JT. Suppression of copulatory behaviour in male rats following central administration of clonidine. Neuropharmacol 1991; 30: 373-382.
42. Crenshaw TL, Goldberg JP. Sexual Pharmacology-Drugs that Affect Sexual Functioning. W.W Norton & Company: New York; 1996; pp 225.
43. Masubuchi Y et al. Disturbance or relatively important actions of antihypertensives, antifungal agent and opiate antagonist to the testicular steroidogenesis in rat. J Toxicol Sci 1992; 17: 41-50.
44. Hedlund H, Andersson KE. Comparison of the responses to drugs acting on adrenoceptors and muscarinic receptors in human isolated corpus cavernosum and cavernous artery. J Auton Pharmacol 1985; 5: 81-88.
45. Kostis JB. Angiotensin converting enzyme inhibitors. II Clinical use. Am Heart J 1988; 116: 1591-1605.
46. Orme M, Breckenridge A. Adverse effects of captopril in hospital outpatients with hypertension. Postgrad Med J 1990; 66: 106-109.
47. Breckenridge A. Angiotensin converting enzyme inhibitors and quality of life. Am J Hypertens 1991; (Suppl) 4: S79-S82.
48. Cruickshank JM. What does the future hold for ACE inhibitors? J Hum Hypertens 1991; 5 (Suppl. 2): 41-47.
49. Zusman R. Renin and non-renin mediated anti-hypertensive action of converting enzyme inhibitors. Kidney Int 1984; 25: 969-983.
50. Croog SH et al. The effects of antihypertensive therapy on quality of life. New Engl J Med 1986; 314: 1657-1664.