Naloxone in the prevention of the adverse cognitive effects of ECT: A within-subject, placebo controlled study

Neuropsychopharmacology

Volumn 21, Issue 2, 1999, Pages 285-293

  Prudic, Joan ^a   Fitzsimons, Linda ^a   Nobler, Mitchell S ^a,b   Sackeim, Harold A ^a,b  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

Author keywords

Amnesia; Cognitive side effects; Electroconvulsive therapy; Memory; Naloxone; Opioid peptides

Indexed keywords

NALOXONE; OPIATE ANTAGONIST; OPIATE RECEPTOR; PLACEBO;

ADULT; AMNESIA; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; COGNITION; COGNITIVE DEFECT; CONTROLLED CLINICAL TRIAL; DEPRESSION; DRUG EFFICACY; ELECTROCONVULSIVE THERAPY; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RETROGRADE AMNESIA; SEIZURE; TREATMENT OUTCOME;

ADULT; AGED; AMNESIA, RETROGRADE; ANALYSIS OF VARIANCE; COGNITION DISORDERS; DEPRESSIVE DISORDER; ELECTROCONVULSIVE THERAPY; FEMALE; HUMANS; MALE; MIDDLE AGED; NALOXONE; NARCOTIC ANTAGONISTS; ORIENTATION; PLACEBOS; SEIZURES; TREATMENT OUTCOME;

EID: 0033043202     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(99)00015-9     Document Type: Article

References (78)

1. Alexopoulos G.S., Inturrisi C.E., Lipman R., Frances R., Haycox J., Dougherty J.H. Jr., Rossier J. Plasma immunoreactive beta-endorphin levels in depression. Effect of electroconvulsive therapy. Arch Gen Psychiatry. 40:1983;181-183.
2. American Psychiatric Association [Weiner RD, Fink M, Hammersley D, Moench L, Sackeim HA, Small I] (1990): The Practice of ECT: Recommendations for Treatment, Training and Privileging. Washington, D.C., American Psychiatric Press.
3. Arnsten A.T., Segal D.S. Naloxone alters locomotion and interaction with environmental stimuli. Life Sci. 25:1979;1035-1042.
4. Belenky G.L., Gelinas-Sorell D., Kenner J.R., Holaday J.W. Evidence for delta-receptor involvement in the post-ictal antinociceptive responses to electroconvulsive shock in rats. Life Sci. 33(Suppl 1):1983;583-585.
5. Benton A.L., Hamsher KdeS Multilingual aphasia examination. 1976;University of Iowa, Iowa City, IA.
6. Carrasco M.A., Dias R.D., Izquierdo I. Naloxone reverses retrograde amnesia induced by electroconvulsive shock. Behav Neural Biol. 34:1982;352-357.
7. Cohen M.R., Cohen R.M., Pickar D., Murphy D., Bunney W.E. Physiological effects of high dose naloxone administration to normal adults. Life Sci. 30:1982;2025-2031.
8. Cohen M.R., Cohen R.M., Pickar D., Weingartner H., Murphy D., Bunney W.E. Behavioral effects after high dose naloxone administration to normal volunteers. Lancet. ii:1981;1110.
9. Cohen M.R., Cohen R.M., Pickar D., Weingartner H., Murphy D., Bunney W.E. High-dose naloxone infusions in normals. Dose-dependent behavioral, hormonal, and physiological responses Arch Gen Psychiatry. 40:1983;613-619. a.
10. Cohen M.R., Cohen R.M., Weingartner H., Pickar D., Murphy High dose naloxone affects task performance in normal subjects. Psychiatry Res. 8:1983;127-136. b.
11. Collier T.J., Routtenberg A. Selective impairment of declarative memory following stimulation of dentate gyrus granule cells. A naloxone-sensitive effect Brain Res. 310:1984;384-387.
12. Colombo P.J., Martinez J.L., Bennett E.L., Rosenzweig M.R. Kappa opioid receptor activity modulates memory for peck-avoidance training in the 2-day-old chick. Psychopharmacology. 108:1992;235-240.
13. Crain B.J., Chang K., McNamara J.O. An in vitro autoradiographic analysis of mu and delta opioid binding in the hippocampal formation of kindled rats. Brain Res. 412:1987;343-351.
14. Daniel W.F., Crovitz H.F., Weiner R.D. Neuropsychological aspects of disorientation. Cortex. 23:1987;169-187.
15. Devanand D.P., Fitzsimons L., Prudic J., Sackeim H.A. Subjective side effects during electroconvulsive therapy. Convuls Ther. 11:1995;232-240.
16. File S.E., Silverstone T. Naloxone changes self-ratings but not performance in normal subjects. Psychopharm. 74:1981;353-354.
17. Flood J.F., Cherkin A., Morley H.E. Antagonism of endogenous opioids modulates memory processing. Brain Res. 422:1987;218-234.
18. Folstein M., Folstein S., McHugh P. "Mini-Mental State" J Psychiatric Res. 12:1975;189-198.
19. Frenk H., Stein B.E. Endogenous opioids mediate ECS-induced catalepsy at supraspinal levels. Brain Res. 303:1984;109-112.
20. Furui T., Harty G.J., Yaksh T.L. Studies on the effects of opioid, noradrenergic and serotonergic antagonists on the antinociceptive effects of electroconvulsive shock. Brain Res. 367:1986;162-168.
21. Gallagher M., King R.A., Young N.V. Opiate antagonists improve spatial memory. Science. 221:1983;975-976.
22. Gorris L.G.M., Van Abeleen J.H.F. Behavioral effects of (-)naloxone in mice from four inbred strains. Psychopharm. 74:1981;355-359.
23. Hannay H.J., Levin H.S. Selective reminding test. An examination of the equivalence of four forms J Clin Exp Neuropsychol. 7:1985;251-263.
24. Hiramatsu M., Mori H., Murasawa H., Kameyama T. Improvement by dynorphin A (1-13) of galanin-induced impairment of memory accompanied by blockade of reductions in acetylcholine release in rats. Br J Pharm. 118:1996;255-260.
25. Hitzemann R.J., Hitzemann B.A., Blatt S., Meyerhoff J.L., Tortella F.C., Kenner J.R., Belenky G.L., Holaday J.W. Repeated electroconvulsive shock. effect on sodium dependency and regional distribution of opioid-binding sites Mol Pharmacol. 31:1987;562-566.
26. Holaday J.W., Hitzemann R.J., Curell J., Tortella F.C., Belenky G.L. Repeated electroconvulsive shock or chronic morphine treatment increases the number of 3H-D-Ala2,D-Leu5-enkephalin binding sites in rat brain membranes. Life Sci. 31:1982;2359-2362.
27. Holaday J.W., Tortella F.C., Meyerhoff J.L., Belenky G.L., Hitzemann R.J. Electroconvulsive shock activates endogenous opioid systems. Behavioral and biochemical correlates Ann NY Acad Sci. 467:1986;249-255.
28. Holtzman S.G. Behavioral effects of separate and combined administration of naloxone and d-amphetamine. J Pharmacol Exp Ther. 189:1974;51-60.
29. Huynh H.S., Feldt L.S. Estimation of the Box correction for degrees of freedom from sample data in randomized block and split-plot designs. J Educ Stat. 1:1976;69-82.
30. Isaac L., Swanger J. Alteration of electroconvulsive threshold by cerebrospinal fluid from cats tolerant to electroconvulsive shock. Life Sci. 33:1983;2301-2304.
31. Izquierdo I. Effect of beta-endorphin and naloxone on acquisition, memory, and retrieval of shuttle avoidance and habituation learning in rats. Psychopharmacology (Berl). 69:1980;111-115.
32. Izquierdo I., Graudenz M. Memory facilitation by naloxone is due to release of dopaminergic and beta-adrenergic systems from tonic inhibition. Psychopharm. 67:1980;265-268.
33. Izquierdo I., Netto C.A. Role of beta-endorphin in behavioral regulation. Ann NY Acad Sci. 444:1985;162-177.
34. Izquierdo I., Netto C.A. Dual action of post-training naloxone on memory. Behav Neural Biol. 53:1990;140-146.
35. Izquierdo I., Souza D.O., Carrasco M.A., Dias R.D., Perry M.L., Eisinger S., Elisabetsky E., Vendite D.A. Beta-endorphin causes retrograde amnesia and is released from the rat brain by various forms of training and stimulation. Psychopharmacology (Berl). 70:1980;173-177.
36. Izquierdo L.A., Schroder N., Ardenghi P., Quevedo J., Netto C.A., Medina J.H., Izquierdo I. Systemic administration of ACTH or vasopressin reverses the amnestic effect of posttraining beta-endorphin or electroconvulsive shock but not that of intrahippocampal infusion of protein kinase inhibitors. Neurobiol Learn Mem. 68:1997;197-202.
37. Jackson H.C., Nutt D.J. Differential effects of selective mu-, kappa- and delta-opioid antagonists on electroshock seizure threshold in mice. Psychopharmacology (Berl). 103:1991;380-383.
38. Jones L.S. Naloxone blocks antiepileptogenic properties of an in vitro electroconvulsive shock model. Brain Res. 564:1991;336-340.
39. Kanamatsu T., McGinty J.F., Mitchell C.L., Hong J.S. Dynorphin- and enkephalin-like immunoreactivity is altered in limbic-basal ganglia regions of rat brain after repeated electroconvulsive shock. J Neurosci. 6:1986;644-649.
40. Krueger R.B., Sackeim H.A., Gamzu E.R. Pharmacological treatment of the cognitive side effects of ECT. A review Psychopharmacol Bull. 28:1992;409-424.
41. Lasön W., Przewöcka B., Przewöcki R. The prodynorphin system in the rat hippocampus is differentially influenced by kainic acid and pentetrazole. Neuroscience. 51:1992;357-362.
42. Levin Y., Elizur A., Korczyn A.D. Physostigmine improves ECT-induced memory disturbances. Neurology. 37:1987;871-875.
43. Levin Y., Salganik I., Etzion T., Levy A., Neuman M., Korczyn A.D. Naloxone fails to improve memory and cognitive disturbances after electroconvulsive treatment. Brain Dysfunct. 3:1990;193-196.
44. Lewis J.W., Cannon J.T., Chudler E.H., Liebeskind J.C. Effects of naloxone and hypophysectomy on electroconvulsive shock-induced analgesia. Brain Res. 208:1981;230-233.
45. Liang K.C., Messing R.B., McGaugh J.L. Naloxone attenuates amnesia caused by amygdaloid stimulation. The involvement of a central opioid system Brain Res. 271:1983;41-49.
46. Mansour A., Khachaturian H., Lewis E., Akil H., Watson S.J. Anatomy of CNS opioid receptors. Trends in Neurosci. 11:1988;306-314.
47. McGaugh J.L. Hormonal influences on memory. Ann Rev Psychol. 34:1983;297-323.
48. Messing R.B., Jensen R.A., Martinez J.L., Spiehler V.R., Vasquez B.J., Soumireu-Mourat B., Liang K.C., McGaugh J.L. Naloxone enhancement of memory. Behav Neural Biol. 27:1979;266-275.
49. Mesulam M.-M. Principles of behavioral neurology. 1985;F. A. Davis, Philadelphia.
50. Morley J.E., Levine A.S. Stress-induced eating is mediated through endogenous opiates. Science. 209:1980;1259-1261.
51. Nakata Y., Chang K.J., Mitchell C.L., Hong J.S. Repeated electroconvulsive shock downregulates the opioid receptors in rat brain. Brain Res. 346:1985;160-163.
52. Nasrallah H.A., Varney N., Coffman J.A., Bayless J., Chapman S. Opiate antagonism fails to reverse post-ECT cognitive deficits. J Clin Psychiatry. 47:1986;555-556.
53. Post R.M. ECT. the anticonvulsant connection Neuropsychopharmacology. 3:1990;89-92.
54. Quirion R. Neuropeptide receptors in the brain. Possible relevance to function. Avoli M., Reader T.A., Dylies R.W., Gloor S.M. Neurotransmitter and Cortical Function. 1988;565-584 Plenum, New York.
55. Randt C.T., Brown R.E. Randt Memory Test. 1983;Life Science, Bayport, NY.
56. Rasmussen K.G., Jarvis M.R., Zorumski C.F. Naloxone and ECT seizure length. Convuls Ther. 13:1997;44-46.
57. Sackeim H.A. The cognitive effects of electroconvulsive therapy. Moos W.H., Gamzu E.R., Thal L.J. Cognitive Disorders. Pathophysiology and Treatment:1992;183-228 Marcel Dekker, New York.
58. Sackeim HA (in press): The anticonvulsant hypothesis of the mechanisms of action of ECT: Current status. J ECT 15:5-26.
59. Sackeim H.A., Decina P., Prohovnik I., Malitz S. Seizure threshold in electroconvulsive therapy. Effects of sex, age, electrode placement, and number of treatments. Arch Gen Psychiatry. 44:1987;355-360.
60. Sackeim H.A., Decina P., Prohovnik I., Malitz S., Resor S.R. Anticonvulsant and antidepressant properties of electroconvulsive therapy. A proposed mechanism of action Biol Psychiatry. 18:1983;1301-1310.
61. Sackeim H.A., Devanand D.P., Nobler M.S. Electroconvulsive therapy. Bloom F., Kupfer D. Psychopharmacology. The Fourth Generation of Progress:1995;1123-1142 Raven, New York.
62. Sackeim H.A., Nobler M.S., Prudic J., Devanand D.P., McElhinney M., Coleman E., Settembrino J., Maddatu V. Acute effects of electroconvulsive therapy on hemispatial neglect. Neuropsychiatry Neuropsychol Behav Neurol. 5:1992;151-160.
63. Sackeim H.A., Portnoy S., Neeley P., Steif B.L., Decina P., Malitz S. Cognitive consequences of low-dosage electroconvulsive therapy. Ann N Y Acad Sci. 462:1986;326-340.
64. Sackeim H.A., Prudic J., Devanand D.P., Kiersky J.E., Fitzsimons L., Moody B.J., McElhiney M.C., Coleman E.A., Settembrino J.M. Effects of stimulus intensity and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy. N Engl J Med. 328:1993;839-846.
65. Shavit Y., Caldecott-Hazard S., Liebeskind J.C. Activating endogenous opioid systems by electroconvulsive shock or footshock stress inhibits recurrent kindled seizures in rats. Brain Res. 305:1984;203-207.
66. Simmons M.L., Chavkin C. Endogenous opioid regulation of hippocampal function. Int Rev Neurobiol. 39:1996;145-196.
67. Sobin C., Sackeim H.A., Prudic J., Devanand D.P., Moody B.J., McElhiney M.C. Predictors of retrograde amnesia following ECT. Am J Psychiatry. 152:1995;995-1001.
68. Stern R.A., Nevels C.T., Shelhorse M.E., Prohaska M.L., Mason G.A., Prange A.J.J. Antidepressant and memory effects of combined thyroid hormone treatment and electroconvulsive therapy. Preliminary findings Biol Psychiatry. 30:1991;623-627.
69. Stuss D.T., Alexander M.P., Hamer L., Palumbo C., Dempster R., Binss M., Levine B., Izukawa D. The effects of focal anterior and posterior brain lesions on verbal fluency. J Int Neuropsychol Soc. 4:1998;265-278.
70. Tortella F.C., Cowan A. EEG, EMG and behavioral evidence for the involvement of endorphin systems in postictal events after electroconvulsive shock in rats. Life Sci. 31:1982;881-888.
71. Tortella F.C., Long J.B. Endogenous anticonvulsant substance in rat cerebrospinal fluid after a generalized seizure. Science. 228:1985;1106-1108.
72. Tortella F.C., Long J.B., Hong J., Holaday J.W. Modulation of endogenous opioid systems by electroconvulsive shock. Convulsive Ther. 5:1989;261-273.
73. Volavka J., Dornbush P., Mallya A., Cho D. Naloxone fails to affect short-term memory in man. Psychiatry Res. 1:1979;89-92.
74. Weizman A., Gil-Ad I., Grupper D., Tyano S., Laron Z. The effect of acute and repeated electroconvulsive treatment on plasma beta-endorphin, growth hormone, prolactin and cortisol secretion in depressed patients. Psychopharmacology (Berl). 93:1987;122-126.
75. Wolkowitz O.M., Tinklenberg J.R. Naloxone's effect on cognitive functioning in drug-free and diazepam-treated normal humans. Psychopharmacology. 85:1985;221-223.
76. Xie C.W., Lee P.H., Takeuchi K., Owyang V., Li S.J., Douglass J., Hong J.S. Single or repeated electroconvulsive shocks alter the levels of prodynorphin and proenkephalin mRNAs in rat brain. Brain Res Mol Brain Res. 6:1989;11-19.
77. Yoshikawa K., Hong J.S., Sabol S.L. Electroconvulsive shock increases preproenkephalin messenger RNA abundance in rat hypothalamus. Proc Natl Acad Sci USA. 82:1985;589-593.
78. Young E.A., Grunhaus L., Haskett R.F., Pande A.C., Murphy-Weinberg V., Akil H., Watson S.J. Heterogeneity in the beta-endorphin immunoreactivity response to electroconvulsive therapy. Arch Gen Psychiatry. 48:1991;534-539.