Investigation of the transport of intact glutathione in human and rat type II pneumocytes

Free Radical Research

Volumn 30, Issue 5, 1999, Pages 371-381

  Van Klaveren, Rob J ^a   Hoet, Peter H M ^a   Demedts, Maurits ^a   Nemery, Benoit ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Cell culture; Cystine; Disulphides; Dithiothreitol; Reduced thiols; Transport mechanism

Indexed keywords

ACIVICIN; BUTHIONINE SULFOXIMINE; DISULFIDE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; OUABAIN; THIOL;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL MEMBRANE TRANSPORT; ENZYME ACTIVITY; ENZYME INHIBITION; EXTRACELLULAR FLUID; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL; NONHUMAN; OXIDATION REDUCTION STATE; PEPTIDE SYNTHESIS; RAT; TIME;

ANIMALS; ANTIMETABOLITES; BIOLOGICAL TRANSPORT; CELLS, CULTURED; CYSTINE; GLUTATHIONE; HUMANS; ISOXAZOLES; LUNG; MALE; OUABAIN; PENICILLAMINE; RATS; RATS, WISTAR; SULFHYDRYL COMPOUNDS;

ANIMALIA; STROPHANTHUS GRATUS;

EID: 0033041536     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.1080/10715769900300411     Document Type: Article

References (27)

1. A. Cantin, S. North, R. Hubbard and R. Crystal (1987). Normal epithelial lining fluid contains high levels of glutathione. Journal of Applied Physiology 63: 152-157.
2. J.E. Heffner and J.E. Repine (1989). Pulmonary strategies of antioxidant defense. American Review of Respiratory Disease 140: 531-554.
3. S.G. Jenkinson, R.D. Black and R.A. Lawrence (1988). Glutathione concentration in rat lung bronchoalveolar lavage fluid: effects of hyperoxia. Journal of Laboratory and Clinical Medicine 112: 345-351.
4. R.J. van Klaveren, M. Demedts and B. Nemery (1997). Cellular glutathione turnover in vitro, with emphasis on type II pneumocytes. European Respiratory Journal 10: 1392-1400.
5. C. Garcia-Ruiz, J.C. Fernandez-Checa and N. Kaplowitz (1992). Bidirectional plasma membrane transport of reduced glutathione in intact hepatocytes and membrane vesicles. Journal of Biological Chemistry 267: 22256-22264.
6. S.C. Lu, J. Ge, H. Huang, J. Kuhlenkamp and N. Kaplowitz (1993). Thiol-disulfide effects on hepatic glutathione transport. Studies in cultured rat hepatocytes and perfused liver. Journal of Clinical Investigation 92: 1188-1197.
7. S.C. Lu, J. Kuhlenkamp, J. Ge, W. Sun and N. Kaplowitz (1994), Specificity and directionality of thiol effects on sinusoidal glutathione transport in rat liver. Molecular Pharmacology 46: 578-585.
8. R.J. van Klaveren, D. Dinsdale, J.L. Pype, M. Demedts and B. Nemery (1997). N-acetylcysteine does not protect against type II cell injury after prolonged exposure to hyperoxia in rats. American Journal of Physiology 273 (Lung Cell Mol. Physiol. 17): L548-L555.
9. C. Bai, L.A. Brown and D.P. Jones (1994). Glutathione transport by type II cells in perfused rat lung. American Journal of Physiology (Lung Cell Mol. Physiol. 11): L447-L455.
10. L.A. Brown, C. Bai and D.P. Jones (1992). Glutathione protection in alveolar type II cells from fetal and neonatal rabbits. American Journal of Physiology 262 (Lung Cell Mol. Physiol. 6): L305-L312.
11. T.M. Hagen, T.Y. Aw and D.P. Jones (1988). Glutathione uptake and protection against oxidative injury in isolated kidney cells. Kidney International 34: 74-81.
12. T.M. Hagen, L.A. Brown and D.P. Jones (1986). Protection against paraquat-induced injury by exogenous GSH in pulmonary alveolar type II cells. Biochemical Pharmacology 35: 4537-4542.
13. T.M. Hagen and D.P. Jones (1987). Transepithelial transport of glutathione in vascularly perfused small intestine of the rat. American Journal of Physiology 252 (Gastrointest. Liver Physiol.): G607-G613.
14. S.G. Jenkinson, R.A. Lawrence, C.A. Zamora and S.M. Deneke (1994). Induction of intracellular glutathione in alveolar type II pneumocytes following BCNU exposure. American Journal of Physiology 266 (Lung Cell Mol. Physiol.): L125-L130.
15. P.H.M. Hoet, C.P.L. Lewis, M. Demedts and B. Nemery (1994). Putrescine and paraquat uptake in human lung slices and isolated type II pneumocytes. Biochemical Pharmacology 48: 517-524.
16. R.J. Richards, N. Davies, J. Atkins and V.I.C. Oreffo (1987). Isolation, biochemical characterization and culture of lung type II cells of the rat. Lung 165: 143-158.
17. L.H. Lash and D.P. Jones (1984). Renal glutathione transport. Journal of Biological Chemistry 259: 14508-14513.
18. L.H. Lash, T.M. Hagen and D.P. Jones (1986). Exogenous glutathione protects intestinal epithelial cells from oxidative injury. Proceedings of the National Academy of Sciences of the USA 83: 834641-834653.
19. S.C. Lu, W.M. Sun, C.N. Nagineni, J.J. Hooks and R. Kannan (1995). Bidirectional glutathione transport by cultured human retinal pigment epithelial cells. Investigative Opthalmology and Visual Science 36: 2523-2530.
20. F. Sze, N. Kaplowitz, M. Ookhtens and S.C. Lu (1993). Bidirectional membrane transport of intact glutathione in Hep G2 cells. American Journal of Physiology 28: G1128-G1134.
21. M.E. Anderson (1985). Determination of glutathione and glutathione disulfide in biological samples. Methods in Enzymology 113: 548-554.
22. M.M. Bradford (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72: 248-254.
23. S.M. Deneke and B.L. Fanburg (1989). Regulation of cellular glutathione. American Journal of Physiology 257 (Lung Cell Mol. Physiol. 1): L163-L173.
24. M. Simionescu (1997). Lung endothelium: structure-function correlates. In: The lung: Scientific foundations Second Edition (eds. Crystal, R.G. and West, J.B.) Raven Press, Philadelphia: pp. 615-628.
25. G.S. Jones, P.R. Miles, R.C. Lantz, D.E. Hinton and V. Castranova (1982). Ionic content and regulation of cellular volume in rat alveolar type II cells. Journal of Applied Physiology 53: 258-266.
26. P. Linsdell and J.W. Hanrahan (1998). Glutathione permeability of CFTR. American Journal of Physiology 275 (Cell Physiol. 44): C323-C326.
27. P.B. McCray, C.L. Wohlford-Lenane and J.M. Snyder (1992). Localization of cystic fibrosis transmembrane conductance regulator mRNA in human fetal lung tissue by in situ hybridization. Journal of Clinical Investigation 90: 619-625.