Methods and considerations for experimental evaluation of antiepileptic drugs

Indian Journal of Physiology and Pharmacology

Volumn 43, Issue 1, 1999, Pages 25-43

  Gupta, Y K ^a   Malhotra, Jatinder ^a   George, B ^b   Kulkarni, S K ^b  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b PANJAB UNIVERSITY   (India)

Author keywords

Anticonvulsants; Experimental models; Screening; Seizures

Indexed keywords

4 AMINOBUTYRIC ACID; 4 HYDROXYBUTYRIC ACID; ANTICONVULSIVE AGENT; BETA CARBOLINE DERIVATIVE; BICUCULLINE; N METHYL DEXTRO ASPARTIC ACID; PENTETRAZOLE; PICROTOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; BABOON; ELECTRIC SHOCK; EPILEPSY; EPILEPTOGENESIS; EXPERIMENTAL MODEL; GERBIL; MOUSE; NONHUMAN; REVIEW; SEIZURE; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; HUMAN; SEIZURES;

ANIMALS; ANTICONVULSANTS; DISEASE MODELS, ANIMAL; HUMANS; PENTYLENETETRAZOLE; SEIZURES;

EID: 0033041343     PISSN: 00195499     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (116)

1. Mattson RH. Drug treatment of partial epilepsy. Adv Neurol 1992; 57: 643-650.
2. De Deyn PP, Hooge RD, Marescau B, Pei YQ. Chemical models of epilepsy with some reference to their applicability in the development of anticonvulsants. Epilepsy Res 1992; 12: 87-110
3. Loscher W, Fassbender CP, Nolting B. The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. II. Maximal electroshock seizures. Epilepsy Res 1991; 8: 79-94.
4. Swinyard EA. Laboratory assay of clinically effective antiepileptic drugs. J Am Pharm Assoc 1949; 38: 201-204.
5. Swinyard EA. Electrically induced convulsions. In: D.P. Purpura, J.K. Penry, D. Tower, D.M., Woodbury and R. Walter (Eds), Experimental models of epilepsy-a manual for the laboratory worker, Raven press. New York, 1972; pp. 433-458.
6. Goddard GV, McIntyre DC, Leech CK. A permanent change in brain function resulting from daily electrical stimulation. Exp Neurol 1969; 25: 295-330.
7. Mc Namara JO. Kindling : an animal model of complex partial epilepsy. Ann Neurol 1984; 16 (Suppl.) : S72-S76.
8. Loscher W, Schmidt D. Which animal models should be used in the search for new antiepileptic drugs ? A proposal based on experimental and clinical considerations. Epilepsy Res 1988; 2: 145-181.
9. Fisher RS. Animal models of the epilepsies. Brain Res Rev 1989; 14: 245-278.
10. Koella WP. Animal experimental methods in the study of antiepileptic drugs. In : H.H Frey and D. Janz (Eds.) Antiepileptic drugs. Handbook of experimental pharmacology, vol. 74, Springer-Berlin, 1985; pp. 283-339.
11. Loscher W, Schwartz-Porsche D, Frey HH, Schmidt D. Evaluation of epileptic dogs as an animal model of human epilepsy. Arzneim-Forsch 1985; 35: 82-87.
12. Seyfried TN, Glaser GH. A review of mouse mutants as genetic models of epilepsy. Epilepsia 1985; 26: 143-150.
13. Loscher W, Czuczwar SJ, Wolff GL. AE mice : an inbred mouse strain with interesting features for epilepsy research. Epilepsia 1986; 27: 657-664.
14. Killam EK. Photomyoclonic seizures in the baboon, Papio papio. Fed Proc 1979; 38: 2429-2433.
15. Loscher W. Genetic models of epilepsy as a unique resource for the evaluation of anticonvulsant drugs-A review. Meth Find Exp Clin Pharmacol 1984; 6: 531-547.
16. Engstrom FL, Woodbury DM. Seizure susceptibility in DBA and C57 mice : the effects of various convulsants. Epilepsia 1988; 29: 389-395.
17. Fuller JL, Collins RL. Temporal parameters of sensitization of audiogenic seizures in SJL/J mice. Dev Psychobiol 1968; 1: 185-188.
18. Kaplan BJ, Seyfried TN, Glaser GH. Spontaneous polyspike discharges in an epileptic mutant mouse (tottering). Exp Neurol 1979; 577-586.
19. Noebels JL, Sidman RJ. Inherited epilepsy : spike-wave and focal motor seizures in the mutant mouse tottering. Science 1979; 204: 1334-1336.
20. Noebels JL. A single gene error of noradrenergic axon growth synchronizes central neurones. Nature (Lond.) 1984; 310: 409-411.
21. Kaplan H. What triggers seizures in the gerbil, Meriones unguiculatus? Life Sci 1975; 17: 693-698.
22. Frey HH, Loscher W, Reichie R, Schultz D. Anticonvulsant potency of common antiepileptic drugs in the gerbil. Pharmacology 1993; 27: 330-335.
23. Sasa M, Ohno Y, Ujihara H, Fujita Y, Yoshimura M, Takaori S, Serikawa T, Yamada J. Effects of antiepileptic drugs on absence like and tonic seizures in a spontaneously epileptic rat, a double mutant rat. Epilepsia 1988; 29: 505-513.
24. Richard RK, Everett GM Analgesic and anticonvulsant properties of 3, 5, 5-trimethyloxazolidine 2, 4-dione (Tridione). Fed Proc 1944; 3: 39-44.
25. Swinyard EA, Brown WC, Goodman LS. Comparative assays of antiepileptic drugs in mice and rats. J Pharmacol Exp Ther 1952; 106: 319-330.
26. Malhotra J, Gupta YK. Effect of adenosine receptor modulation on pentylenetetrazole-induced seizures in rats. Br J Pharmac 1997; 120: 282-288.
27. Olsen RW. The GABA postsynaptic membrane receptor-ionophore complex. Site of action of convulsant and anticonvulsant drugs. Mol Cell Biochem 1981; 39: 261-279.
28. Frey HH, Loscher W. Di-n-propylacetic acid: profile of anticonvulsant activity in mice. Arzneim Forsch (Drug Res) 1976; 26: 299-301.
29. Killian M, Frey HH. Central monoamines and convulsive thresholds in mice and rats. Neuropharmacology 1973; 12: 681-692.
30. Osonoe K, Mori N, Suzuki K, Osonoe M. Antiepileptic effects of inhibitors of nitric oxide synthase examined in pentylenetetrazole-induced seizures in rats. Brain Res 1994; 663: 338-340.
31. Kubova H, Rathouska J, Mares P. Anticonvulsant effects of bretazenil (Ro 16-6028) during ontogenesis. Epilepsia 1993; 34: 1130-1134.
32. Loscher W, Honack D, Fassbender CP, Nolting B. The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazole seizures models. Epilepsy Res 1991; 8: 171-189.
33. Desmedt LKC, Niemegeers CJE, Janssen PAJ. Antagonism of maximal metrazol seizures in rats and its relevance to an experimental classification of antiepileptic drugs. Arzneim Forsch (Drug Res) 1976; 26: 1592-1602.
34. Piredda SG, Woodhead JH, Swinyard EA. Effects of stimulus intensity on the profile of anticonvulsant activity of phenytoin, ethosuximide and valproate. J Pharmacol Exp Ther 1985; 232: 741-745.
35. Malhotra J, Seth SD, Gupta SK, Gupta YK. Adenosinergic mechanisms in anticonvulsant action of diazepam and sodium valproate. Env Toxicol Pharmacol 1996; 1: 269-277.
36. Ono J, Vieth RF, Walson PD. Electrocorticographical observation of seizures induced by pentylenetetrazole (PTZ) injection in rats. Functional Neurol 1990; 5: 345-352.
37. Gupta YK, Malhotra J. Effect of theophyiline on diazepam and sodium valproate protection in pentylenetetrazole-kindled seizures in rats. Indian J Physiol Pharamcol 1997; 41: 280-284.
38. Corda MG, Orlandi M, Carboni G, Frau V, Giorgi O. Pentylenetetrazole-induced kindling in rats: Effects of GABA function inhibitors. Pharmacol Biochem Behav 1991; 40: 329-333.
39. Nagai T, Suzuki Y, Arai H, Imai K, Kodaka R, Itagaki Y, Tanaka J, Ono J, Okada S. Effects of pentylenetetrazole (PTZ) kindling on GABAergic system: A histochemical study by staining for GABA-transaminases (GABA-T). Jpn J Psychiatr Neurol 1993; 47: 392-393.
40. Remler MP, Sigvardt K, Marcussen WH. Pharmacological response of systemically derived focal epileptic lesions. Epilepsia 1986; 27: 671-677.
41. Porter RJ, Cereghino JJ, Gladding GD, Hessie BJ, Kupferberg HJ, Seoville B, White BG. Antiepileptic drug development programme. Clev Clin Quart 1984; 103: 287-293.
42. Ticku MK, Rastogi SK. Convulsant/anticonvulsant drugs and GABAergic transmission. In Nistico G, Morseilli PL, Llloyd KG, Fareillo RG and Engel J Jr. (Eds.) Neurotransmitte'rs, Seizures and Epilepsy Raven Press New York, 1986; pp. 163-177.
43. Cepeda C, Tanaka T, Besselievre R, Potier P, Naquet R, Rossier J. Proconvulsant effects in baboons of β-carboline, a putative endogenous ligand for benzodiazepine receptors. Neurosci Lett 1981; 24: 53-57.
44. Cowen PJ, Green AR, Nutt DJ, Martin IL. Ethyl β-carboline carboxylate lowers seizure threshold and antagonizes flurazepam-induced sedation in rats. Nature 1981; 290: 54-55.
45. Johnson DD, Fisher TE, Tuchek JM, Crawford RD. Pharmacology of methyl and propyl β-carbolines in a hereditary model of epilepsy. Neuropharmacology 1984; 23: 1015-1017.
46. Prado de Carvallho L, Grecksch G, Cavalheiro EA, Dodd RH, Chapouthe G, Rossier J. Characterization of convulsions induced by methyl β-carboline-3-carboxylate in mice. 1984; 103: 287-293.
47. Petersen EN. DMCM: a potent convulsive benzodiazepine receptor ligand. Eur J Pharmacol 1983; 94: 117-124.
48. Braestrup C, Nielsen M, Olsen CE. Urinary and brain β-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors. Proc Natl Acad Sci (USA) 1980; 77: 2288-2292.
49. Snead OC. Gammahydroxybutyrate in the monkey. Life Sci 1978; 20: 1935-1944.
50. Depaulis A, Bourgignon J, Marescaux C, Vergnes M, Schmitt M, Micheletti G, Warter JM. Effect of r-hydroxybutyrate and r-butyrolactone derivatives on spontaneous generalized non-convulsive seizures in the rat. Neuropharmacology 1988; 27: 683-689.
51. Depaulis A, Snead OC, Marescaux C, Vergnes M. Suppressive effect of intranigral injection of muscimol in three models of generalized non convulsive seizures in the rat. Brain Res 1989; 498: 64-72.
52. Snead OC. r-hydroxybutyrate model of generalized absence seizures: further characterization and comparison with other absence models. Epilepsia 1988; 29: 361-368.
53. Snead III OC. The r-hydroxybutyrate model of absence seizures: correlation of regional brain levels of r-hydroxybutyric acid and r-butyrolactone with spike wave discharges. Neuropharmacology 1991; 30: 161-167.
54. Ono K, Baba H, Sugai S. A new chronic model of spontaneous nonconvulsive generalized seizures. Japan J Psychiatr Neurol 1993; 47: 396-397.
55. 3H]G-hydroxbutyrate on cultured neurones of rat cerebellum and spinal cord. Neurosci Lett 1983; 42: 145-148.
56. Roth RH, Doherty JD, Walters JR. Gamma-hydroxybutyrate: a role in the regulation of central depaminergic neurons. Brain Res 1980; 189: 556-560.
57. Turski L, Niemann W, Stephens DN. Differential effects of antiepileptic drugs and β carbolines on seizures induced by excitatory amino acids. Neurosciences 1990; 39: 799-807.
58. Olney JW, Rhee V, Ho OL Kainic acid: a powerful neurotoxic analog of glutamate. Brain Res 1974; 77: 501-512.
59. Scerrati M, Onofri M, Pacifici L, Pola P, Rammaci MT, Rossi GF. Electrocerebral and behavioural analysis of systemic kainic acid-induced epilepsy in the rat. Drug Exp Clin Res 1986; 12: 671-680.
60. Lockard JS, Uhlir V, Ducharme LL, Farquhar JA, Huntsman BJ. Efficacy of standard anticonvulsants in monkey model with spontaneous motor seizures. Epilepsia 1975; 16: 301-317.
61. Tanaka T, Kaijima M, Yonemasu Y, Cepeda C. Spontaneous secondarily generalized seizures induced by a single microinjection of kainic acid into unilateral amygadala in cats. Electroenceph Clin Neurophysiol 1985; 61: 422-429.
62. Ben-Ari Y. Limbic Seizure and brain damage produced by kainic acid: mechanisms and relevance to humantemporal lobe epilepsy. Neuroscience 1985; 14: 375-408.
63. Carrea R, Lanari A. Chronic effect of tetanus toxin applied locally to the cerebral cortex of dog. Science 1962; 137: 342-343.
64. Melanby J, Hawkins C, Mellanby H, Rawlins JNP, Impey ME. Tetanus as a tool for studying epilepsy J Physiol 1984; 79: 207-215.
65. Van Heyningen S. Tetanus toxin. Pharmacol Ther 1980; 11: 477-484.
66. Walker AE, Johnson HC. Convulsive factor in commercial penicillin. Arch Surg 1945; 50: 69-73.
67. Fariello RG. Parenteral penicillin in rats: an experimental model for multifocal epilepsy. Epilepsia 1976; 16: 217-222.
68. Prince DA and Farell D. Centrencephalic spike wave discharges following parenteral penicillin injection in the rat. Neurology 1969; 19: 309-310.
69. Fisher RS and Prince DA. Spike-wave rhythm in cat cortex induced by parenteral penicillin 1. Electroencephalographic features. Electroencephal Clin Neurophysiol 1977; 42: 608-624.
70. Guberman A, Gloor P, Sherwin AL. Response of generalized penicillin epilepsy, in the cat to ethosuximide and diphenhydantoin. Neurology 1975; 25: 785-864.
71. Pellegrini N, Gloor P, Sherwin AL. Effect of valproate sodium on generalized penicillin epilepsy in the cat. Epilepsia 1978; 19: 351-360.
72. Kopeloff LM, Chusid JG, Kopeloff N. Epilepsy in Macacca mulatta after cortical or intracerebral alumina. Arch Neurol Psychiatry 1955; 74: 523-526.
73. Hanna GR, Stalmaster RM. Cortical epileptic lesions produced by freezing. Neurology 1973; 23: 918-925.
74. Loiseau H, Averet N, Arrigoni F, Cohadon F. The early phase of cryogenic lesions: an experimental model of seizures updated. Epilepsia 1987; 28: 251-258.
75. Karpiak SE, Graf L, Rapport MM. Antibodies to brain gangliosides produces recurrent epileptiform activity. Science 1976; 194: 735-737.
76. Karpiak SE, Mahadik SP, Fraf L, Rapport MM. An immunological model of epilepsy: seizures induced by antibodies to G.M.I ganglioside. Epilepsia 1981; 22: 189-196.
77. Gupta YK, Malhotra J. Influence of adenosine agonists and antiepileptic drugs on theophylline-induced seizures in rats. Indian J Physiol Pharmacol 1998; 42: 491-497
78. Chang CWJ, Bleck TP. Status Epilepticus. Neurologic Clinics 1995; 13: 529-548.
79. McIntyre DC, Edson N. Kindling based status epilepticus, effects of norepinephrine depletion with 6-hydroxydopamine. Exp Neurol 1989; 104: 10-14.
80. McIntyre DC, Stokes KA, Edson N. Status epilepticus following stimulation of a kindled hippocampal focus in intact and commissurotomized rats. Exp Neurol 1986; 94: 554-570.
81. Vicedomini JP, Nadler V. A model of status epilepticus based on electrical stimulation of hippocampal afferent pathways. Exp Neurol 1987; 96: 681-691.
82. Taber KH, McNamara JJ, Zornetzer SF. Status epilepticus: a new rodent model. Electroencephal Clin Neurophysiol 1977; 43: 707-724.
83. Lothman EW, Bertram EH, Bekenstein JW, Perlin JB. Self sustaining limbic status epilepticus induced by 'continuous' hippocampal stimulation. Electrographic and behavioural characteristics. Epilepsy Res 1989; 3: 107-119.
84. George B, Mathur R, Kulkarni SK. Development of self sustaining limbic status epilepticus by continuous ventral hippocampal stimulation followed by low dose pilocarpine in rats. Indian J Physiol Pharmacol 1998; 42.
85. Meldrum BS, Horton RW. Convulsive effects of 4-deoxypryridoxine and of bicuculline in photosensitive baboons (Papio papio) and in rhesus monkey (Macaca mulatta). Brain Res 1971; 35: 419-436.
86. Walton NY, Treiman DM. Experimental secondarily generalized convulsive status epilepticus induced by DL-homocysteine thiolactone. Epilepsy Res 1988; 2: 79-86.
87. Chronopoulos A, Strafstrom C, Thurber S, Hyde P, Mikati M, Holmes GL. Neuroprotective effect of felbamate after kainic-acid-induced status epilepticus. Epilepsia 1993; 34: 359-366.
88. Stafstrom C, Thompson JL, Chronopoulos A, Thurber S, Holmes GL. Effect of age on behavioural abnormalities following kainic acid-induced status epilepticus. Ann Neurol 1990; 28: 467-468.
89. Olney JW. Excitotoxins : an overview. In Excitotoxins. Fuxe K, Roberts P, Schwartz R (Eds.) Macmillan press, London, 1983; pp 82-96.
90. Turski WA, Cavalheiro EA, Schwarz M, Czuczwar SJ, Kleinrok Z, Turski L. Limbic seizures produced by pilocarpine in rats: Behavioural, electroencephalographic and neuropathological study. Behav Brain Res 1983; 9: 315-336.
91. Turski WA, Cavalheiro EA, Coimbra C, Berzaghi MP, Ikonomidou-Turski C, Turski L. Only certain antiepileptic drugs prevent seizures induced by pilocarpine. Brain Res Rev 1987; 12: 281-305.
92. Persinger MA, Makarec K, Bradley JC. Characteristics of limbic seizures evoked by peripheral injections of lithium and pilocarpine. Physiol Behav 1988; 44: 27-37.
93. George B, Mathur R, Kulkarni SK. Protective effect of acute clozapine on pilocarpine models of status epilepticus in rats: a behavioural, electroencephalographic and neuropathological Study. Asia Pac J Pharmacol 1998; communicated.
94. Kulkarni SK, George B. Lithium-pilocarpine neurotoxicity: A potential model of status epilepticus. Meth Find Exp Clin Pharmacol 1995; 17: 551-567.
95. Chaudhary G, Chaudhary JD, malhotra J, Gopinath G, Gupta YK. Status epilepticus by pilocarpine in lithium primed rats : Does treatment schedule affect seizures and neuromal degeneration. Indian J Physiol Pharmacol 1997; 41(5suppl): 480A.
96. Yokoi I, Toma J, Liu J, Kabuto H, Mori A. Adenosines scavenged hydroxytradicals and prevented post-traumatic epilespy. Free Rad Biol Med 1995; 19: 473-479.
97. Kabuto H, Yokoi I, Ogawa N. Melatonin inhigits iron-induced epileptic discharges in rats by suppressing peroxidation. Epilepsia 1998; 39: 237-243.
98. Willmore LJ, Hurd RW, Sypert GW. Epileptiform activity initiated by pial iontophoresis on ferrous and ferric chloride on rat cerebral cortex. Brain Res 1978; 152: 406-410.
99. willmore LJ, Sypert GW, Munson JB. Recurrent seizures induced by cortical iron injection: A model of post-traumatic epilepsy. Ann Neurol 1978; 4: 329-336.
100. Willmore LJ, Sypert GW, Munson JB, Hurd RW. Chronic focal epileptiform discharges induced by injection of iron into rat and cat cortex. Science 1978; 200: 150-153.
101. Rosen AD, Frumin NV. Focal epileptogensis after intracortical hemoglobin injection. Exp Neurol 1979; 66: 277-284.
102. Gross PM, Weaver DF. A new experimental model of epilepsy based on the intraventricular injection of endothelin. J Cardiovasc Pharmacol 1993; 22 Suppl 8: S282-S287.
103. Backstrom T, Gee KW, Lan N, Sorensen M, Wahlstrom G. Steroids in relation to epilepsy and anesthesia. In: M.A. Simmods (Eds.), Steroids and Neuronal activity, Wiley, Chichester, 1990; pp. 225-239.
104. Tauboll E, Lundervold A, Gjerstad L. Temporal distribution of seizures in epilepsy. Epilepsy Res 1991; 8: 153-165.
105. Wahnschaffe U, Loscher W. Lack of chages in seizure susceptibility during the estrous cycle in kindled rats. Epilepsy Res 1992; 13: 199-204.
106. Bourgeois BFD, Dodson WE, Ferrendelli JA. Primidone, phenobarbital and PEMA. I. Seizure protection, neurotoxicity, and therapeutic index of individual compounds in mice. Neurology 1983; 33: 283-290.
107. Gladding GD, Kupferberg HJ, Swinyard EA. Antiepileptic drug develoment programme. In : H.H. Frey and D. Janz (Eds.) Antiepileptic drugs. Handbook of experimental pharmacology, Vol. 74, Springer-Berlin, 1985; pp. 341-347.
108. Jones GL, Wimbish GH. Hydantoins. In : H.H. Frey and D. Janz (Eds.) Antiepileptic drugs. Handbook of experimental pharmacology, Vol. 74, Springer-Berlin, 1985; pp. 351-419.
109. Kupferberg HJ. Antiepileptic drug development program : A cooperative effort of goverenment and Industry. Epilepsia 1989; 30 (suppl. 1): S51-S56.
110. Frey HH. Primidone, In : H.H. Frey and D. Janz (Eds.) Antiepileptic drugs. Handbook of experimental pharmacology, Vol. 74, Springer-Berlin, 1985; pp. 449-477.
111. Schmutz M. Carbamazepine. In : H.H. Frey and D. Janz (Eds.) Antiepileptic drugs. Handbook of experimental pharmacology, Vol. 74, Springer-Berlin, 1985; pp. 479-506.
112. Worms P, Lloyd KG. Functional alterations of GABA synapses in relation to sizures. In : P.L. Morselli, K.G. Lloyd, W. Loscher, B Meldrum and E. H. Reynolds (Eds.), Neurotransmitters, seizures and epilepsy. Raven Press, New York, 1981; pp. 37-48.
113. Loscher W. GABA-mimetics in animal models of seizure states. In : G. Bartholini, L. Bossi, K.G. Lloyd and P.L. Morselli (Eds.), Epilepsy and GABA receptor agonists, basic and therapeutic research, Raven Press, New York, 1985; pp. 109-119.
114. Chweh AY, Swinyard EA, Wolf HH, Kupferberg HJ. Effect of GABA agonists on the neurotoxicity and anticonvulsant activity of benzodiazepines. Life Sci 1985; 36: 737-744.
115. Paul V, Kazi M. A technique for qunatitative measurement of clonic convulsions in rats. Indian J Physiol Pharmacol 1994; 38: 125-128.
116. Malhotra J, Velpandian T, Gupta YK. A simple device for recording seizure activity in rats. Meth Find Exp Clin Pharmacol 1997; 19: 47-51.