Elevation of CD5+ B lymphocytes in schizophrenia

Biological Psychiatry

Volumn 46, Issue 1, 1999, Pages 110-118

  Printz, David J ^a   Strauss, David H ^a   Goetz, Raymond ^a   Sadiq, Saud ^b   Malaspina, Dolores ^b   Krolewski, John ^b   Gorman, Jack M ^a  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b Columbia Univ Coll Phys S ^*  (United States)

Author keywords

antipsychotic; autoimmunity; CD5+ B lymphocyte; pathophysiology; Schizophrenia

Indexed keywords

CD5 ANTIGEN;

ADULT; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE MARKER; FEMALE; HUMAN; IMMUNOFLUORESCENCE; LYMPHOCYTE SUBPOPULATION; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SCHIZOPHRENIA;

ADULT; ANTIGENS, CD5; ANTIGENS, CD8; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; SCHIZOPHRENIA; T-LYMPHOCYTE SUBSETS;

EID: 0033040416     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(98)00307-2     Document Type: Article

References (60)

1. + B lymphocytes and the activity of systemic autoimmunity. Clin Immunol Immunopathol. 56:1990;219-225.
2. + B) in rheumatoid arthritis and primary Sjögren's syndrome. Clin Exp Immunol. 77:1989;175-178.
3. Bruce L.C., Peebles A.M.S. Quantitative and qualitative leukocyte counts in various forms of mental illness. J Mental Sci. 50:1904;409-417.
4. + B cells from patients with rheumatoid arthritis. J Exp Med. 168:1988;1979-1992.
5. + B-cell subset. Science. 236:1987;77-81.
6. Casali P., Kasaian M.T., Haughton G. B1 (CD5) cells. Coutinho A., Kazatchkine M.D. Autoimmunity Physiology and Disease . 1994;Wiley-Liss, New York.
7. Chengappa K.N.R., Carpenter A.B., Yang Z.W., Brar J.S., Rabin B.S., Ganguli R. Elevated IgG antihistone antibodies in a subgroup of medicated schizophrenic patients. Schizophr Res. 7:1992;49-54.
8. Coffey C.E., Sullivan J.L., Rice J.R. T lymphocytes in schizophrenia. Biol Psychiatry. 18:1983;113-119.
9. + B cells and CD4-8 T cells in neuroimmunological diseases. J Neuroimmunol. 32:1991;123-132.
10. Dauphinee M., Tovar Z., Talal N. B cells expressing CD5 are increased in Sjögren's syndrome. Arthritis Rheum. 31:1988;642-647.
11. DeLisi L.E., Goodman S., Neckers L.M., Wyatt R.J. An analysis of lymphocyte subpopulations in schizophrenic patients. Biol Psychiatry. 17:1982;1003-1009.
12. Ekerfelt C., Ernerudh J., Solders G., Vrethem M. CD5 expression on B cells may be an activation marker for secretion of anti-myelin antibodies in patients with polyneuropathy associated with monoclonal gammopathy. Clin Exp Immunol. 101:1995;346-350.
13. Fessel W.K., Hirata-Hibi M. Abnormal leukocytes in schizophrenia. Arch Gen Psychiatry. 9:1963;601-613.
14. Fieve R.R., Blumenthal B., Little B. The relationship of atypical lymphocytes, phenothiazines and schizophrenia. Arch Gen Psychiatry. 15:1966;529-534.
15. Ganguli R., Brar J.S., Chengappa K.N.R., Yang Z.W., Nimgaonkar V.L., Rabin B.H. Autoimmunity in schizophrenia A review or recent findings . Ann Med. 25:1993;489-496.
16. Ganguli R., Rabin B.S. CD5 positive B lymphocytes in schizophrenia No alteration in numbers or percentages as compared with control subjects . Psychiatry Res. 48:1993;69-78.
17. Ganguli R., Rabin B.S. Increased serum interleukin 2 receptor concentration in schizophrenic and brain-damaged subjects. Arch Gen Psychiatry. 46:1989;292.
18. Geng Y., Savage S.M., Johnson L.J., Seagrave J., Sopori M.L. Effects of nicotine on the immune response. I. Chronic exposure to nicotine impairs antigen receptor-mediated signal transduction in lymphocytes. Toxicol Appl Pharmacol. 135:1995;268-278.
19. Geng Y., Savage S.M., Razanai-Boroujerdi S., Sopori M.L. Effects of nicotine on the immune response. II. Chronic nicotine treatment induces T cell anergy. J Immunol. 156:1996;2384-2390.
20. Heath R.G., McCarron K.L., O'Neil C.E. Antiseptal brain antibody in IgG of schizophrenic patients. Biol Psychiatry. 25:1989;725-733.
21. Henneberg A., Riedl B., Dumke H.O., Kornhuber H.H. T-lymphocyte subpopulations in schizophrenic patients. Eur Arch Psychiatry Clin Neurosci. 239:1990;283-284.
22. Henneberg A.E., Horter S., Ruffert S. Increased prevalence of antibrain antibodies in the sera from schizophrenic patients. Schizophr Res. 14:1994;15-22.
23. Herzenberg L.A., Stall A.M., Lalor P.A., et al. The Ly-1 B cell lineage. Immunol Rev. 93:1986;81-102.
24. Hirata-Hibi M., Higashi S., Tachibana T., Vatanabi N. Stimulated lymphocytes in schizophrenia. Arch Gen Psychiatry. 39:1982;82-87.
25. Jamin C., Lamour A., Pennec Y.L., Hirn M., Le Goff P., Youinou P. Expression of CD5 and CD72 on T and B cell subsets in rheumatoid arthritis and Sjögren's syndrome. Clin Exp Immunol. 92:1993;245-250.
26. low B cell subset. Ann N Y Acad Sci. 651:1992;59-69.
27. Kay S.R., Fiszbein A., Opler L.A. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 13:1987;261-276.
28. Kilidireas K., Latov N., Strauss D.H., et al. Antibodies to the human 60 kDa heat-shock protein in patients with schizophrenia. Lancet. 340:1992;569-572.
29. Kipps T.J. The CD5 B cell. Adv Immunol. 47:1989;117-181.
30. Kipps T.J., Vaughan J.H. Genetic influences on the levels of circulating CD5 B lymphocytes. J Immunol. 139:1987;1060-1064.
31. Kirch D.G. Infection and autoimmunity as etiologic factors in schizophrenia A review and reappraisal . Schizophr Bull. 19:1993;355-370.
32. Knight J.G., Knight A., Menkes D.B., Mullen P.E. Autoantibodies against brain septal region antigens specific to unmedicated schizophrenia? Biol Psychiatry. 28:1990;467-474.
33. Li Q., Geiselhart L., Mittler J.N., Mudzinski S.P., Lawrence D.A., Freed B.M. Inhibition of human T lymphoblast proliferation by hydroquinone. Toxicol Appl Pharmacol. 139:1996;317-323.
34. Licinio J., Seibyl J.P., Altemus M., Charney D.S., Krystal J.H. Elevated CSF levels of interleukin-2 in antipsychotic-free schizophrenic patients. Am J Psychiatry. 150:1993;1408-1410.
35. + B cells and the immune system. Immunol Lett. 38:1993;159-166.
36. + B) cells make somatically hypermutated high affinity IgM rheumatoid factors. J Immunol. 151:1993;473-488.
37. + B cell subset in the remission phase of systemic connective tissue diseases. J Rheumatol. 21:1994;2225-2230.
38. Masserini C., Vita A., Basile R., et al. Lymphocyte subsets in schizophrenic disorders. Schizophr Res. 3:1990;269-275.
39. + B lymphocytes in schizophrenic patients. Arch Gen Psychiatry. 46:1989;890-894.
40. McAllister C.G., Rapaport M.H., Pickar D., Paul S.M. Effects of short-term administration of antipsychotic drugs on lymphocyte subsets in schizophrenic patients. Arch Gen Psychiatry. 46:1989;956-995.
41. Mix E., Olsson T., Correale J., et al. B cells expressing CD5 are increased in cerebrospinal fluid of patients with multiple sclerosis. Clin Exp Immunol. 79:1990;21-27.
42. Müller N., Hofschuster E., Ackenheil M., Eckstein R. T-cells and psychopathology in schizophrenia Relationship to the outcome of antipsychotic therapy . Acta Psychiatr Scand. 87:1993;66-71.
43. - B lymphocytes in IDDM. Diabetologia. 38:1995;62-72.
44. Muñoz A., Gallart T., Vinas O., Gomis R. Increased CD5-positive B lymphocytes in type I diabetes. Clin Exp Immunol. 83:1991;304-308.
45. Nurnberger J.I., Blehar M.C., Kaufmann C.A., et al. Diagnostic interview for genetic studies. Arch Gen Psychiatry. 51:1994;849-859.
46. Nyland H., Næss A., Lunde H. Lymphocyte subpopulations in peripheral blood from schizophrenic patients. Acta Psychiat Scand. 61:1980;313-318.
47. Overall J.E., Gorham D.R. The Brief Psychiatric Rating Scale. Psychol Rep. 10:1962;799-812.
48. Pelonero A.L., Pandurangi A.K., Calabrese V.P. Autoantibodies to brain lipids in schizophrenia. Am J Psychiatry. 147:1990;661-662.
49. Plater-Zyberk C., Maini R.N., Lam K., Kennedy T.D., Janossy G. A rheumatoid arthritis B cell subset expresses a phenotype similar to that in chronic lymphocytic leukemia. Arthritis Rheum. 28:1985;971-976.
50. Rapaport M.H., McAllister C.G., Kim Y.S., et al. Increased serum soluble interleukin-2 receptors in Caucasian and Korean schizophrenic patients. Biol Psychiatry. 35:1994;767-771.
51. Rapaport M.H., McAllister C.G., Pickar D., Nelson D.L., Paul S.M. Elevated levels of soluble interleukin 2 receptors in schizophrenia. Arch Gen Psychiatry. 46:1989;292-292.
52. Shima S., Yano K., Sugiura M., Tokunaga Y. Anticerebral antibodies in functional psychoses. Biol Psychiatry. 29:1991;322-328.
53. + B cells in autoimmune disease and lymphoid malignancy. Clin Immunol Immunopathol. 59:1991;173-186.
54. Sirota P., Firer M.A., Schild K., et al. Autoantibodies to DNA in multicase families with schizophrenia. Biol Psychiatry. 33:1993;450-455.
55. Sundin U., Thelander S. Antibody reactivity to brain membrane proteins in serum from schizophrenic patients. Brain Behav Immun. 3:1989;345-358.
56. Talal N., Dauphinee M., Ahmed S.A. CD5 B cells in autoimmunity. Ann N Y Acad Sci. 651:1992;551-556.
57. Torrey E.F., Upshaw Y.D., Suddath R. Medication effect on lymphocyte morphology in schizophrenia. Schizophr Res. 2:1989;385-390.
58. Villemain F., Chatenoud L., Galinowski A., et al. Aberrant T cell-mediated immunity in untreated schizophrenic patients Deficient interleukin-2 production . Am J Psychiatry. 146:1989;609-616.
59. Yannitsi S.G., Manoussakis M.N., Mavridis A.K., et al. Factors related to the presence of autoantibodies in patients with chronic mental disorders. Biol Psychiatry. 27:1990;747-756.
60. Zucker S., Zarrabi H.M., Schubach W.H., et al. Chlorpromazine-induced immunopathy Progressive increase in serum IgM . Medicine. 69:1990;92-100.