Effects of nitric oxide inhalation on pulmonary gas exchange during exercise in highly trained athletes

Acta Physiologica Scandinavica

Volumn 165, Issue 2, 1999, Pages 169-176

  Durand, Fabienne ^a   Mucci, P ^a   Safont, L ^a   Prefaut, C ^a  

^a HÔPITAL ARNAUD DE VILLENEUVE   (France)

Author keywords

Exercise induced hypoxaemia; Highly trained athletes; Histamine release; Nitric oxide; Stress failure

Indexed keywords

HISTAMINE; NITRIC OXIDE; VASODILATOR AGENT;

ADULT; ARTERIAL GAS; ARTERIAL OXYGEN SATURATION; ARTICLE; ATHLETE; BLOOD GAS ANALYSIS; HISTAMINE RELEASE; HUMAN; HUMAN EXPERIMENT; HYPOXEMIA; INHALATIONAL DRUG ADMINISTRATION; LUNG EDEMA; LUNG GAS EXCHANGE; MALE; NORMAL HUMAN; PHYSICAL ACTIVITY; PRIORITY JOURNAL; REST;

ADMINISTRATION, INHALATION; ADULT; ANOXEMIA; BLOOD GAS ANALYSIS; EXERCISE; FOLLOW-UP STUDIES; HISTAMINE; HUMANS; LUNG; MALE; NITRIC OXIDE; PULMONARY CIRCULATION; PULMONARY GAS EXCHANGE; REFERENCE VALUES; SPORTS; VASODILATION; VASODILATOR AGENTS;

EID: 0033039964     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-201x.1999.00480.x     Document Type: Article

References (36)

1. Anselme, F., Caillaud, C., Couret, T., Rossi, M. & Préfaut, C. 1994. Histamine and exercise-induced hypoxemia in highly trained athletes. J Appl Physiol 76, 127-132.
2. Anthonisen, N.R. & Fleetham, J.A. 1987. Ventilation: total, alveolar, and dead space. In: Handbook Physiology. The Respiratory System Gas Exchange, Sect 3, Vol. IV, ch. 8, pp. 113-129. Am Physiol Soc, Bethesda, MD.
3. Barbera, J.A., Roger, N., Roca, J., Rovira, I., Higenbottam, T.M. & Rodriguez-Roisin, R. 1996. Worsening of pulmonary gas exchange with nitric oxide inhalation in chronic obstructive pulmonary disease. Lancet 347, 435-440.
4. Caillaud, C., Serre-Cousine, O., Anselme, F., Capdevilla, X. & Préfaut, C. 1995. Computerized tomography and pulmonary diffusing capacity in highly-trained athletes after performing a triathlon. J App Physiol 79, 1226-1232.
5. Chwalbinska-Moneta, J. & Hanninen, O. 1989. Effect of active warning-up on thermoregulatory, circulatory, and metabolic responses to incremental exercise in endurance-trained athletes, Int J Sports Med 10, 25-29.
6. Dempsey, J.A., Hanson, P.G. & Henderson, K.S. 1984. Exercise-induced arterial hypoxemia in healthy human subjects at sea level. J Physiol London 355, 161-175.
7. Dupuy, P.M., Shore, S.A., Drazen, J.M., Frostell, C.G., Hill, W.A. & Zapol, W.M. 1992. Bronchodilatator action of inhaled nitric oxide in guinea pigs. J Clin Invest 90, 421-428.
8. Foubert, L., Fleming, B., Latimer, R. et al. 1992. Safety guidelines for use of nitric oxide. Lancet 339, 1615-1616.
9. Frostell, C.G., Blomqvis, H., Hedenstierna, G., Lundberg, J. & Zapol, W.M. 1993. Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilation. Anesthesiology 78, 427-435.
10. Gaboury, J.P., Niu, X.F. & Kubes, P. 1996. Nitric oxide inhibits numerous features of mast cell-induced inflammation. Circulation 93, 318-326.
11. Hammond, M.D., Gale, G.E., Kapitan, K.S., Ries, A. & Wagner, P.D. 1986. Pulmonary gas exchange in humans during exercise at sea level. J Appl Physiol 60, 1590-1598.
12. Holmgreen, A. & Mc Ilroy, M.B. 1991. Effect of body temperature on arterial blood gas tensions and pH during exercise. Respir Physiol 83, 143-154.
13. Hopkins, S.R., Belzberg, A.S., Wiggs, B.R. & McKenzie, D.C. 1996. Pulmonary transit time and diffusion limitation during heavy exercise in athletes. Respir Physiol 103, 67-73.
14. Ignarro, L.J., Lippton, H., Edwards, J.C. et al. 1981. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of s. nitrosothiols as active intermediates. J Pharmacol Exp Ther 218, 739-749.
15. Koizumi, T., Gupta, R., Banerjee, M. & Newman, J.H. 1994. Changes in pulmonary vascular tone during exercise. Effects of nitric oxide (NO) synthase inhibition, 1-arginine infusion and NO inhalation. J Clin Invest 94, 2275-2282.
16. Lichtenstein, L.M. & Osler, A. 1964. Studies of the mechanisms of hypersensitivity phenomena. J Exp Med 120, 507-529.
17. Manier, G., Moinard, J. & Stoicheff, H. 1993. Pulmonary diffusing capacity after maximal exercise. J Appl Physiol 75, 2580-2585.
18. Masini, E., Gambassi, F., Di Bello, M.G., Mugnai, L., Raspanti, S. & Mannaioni, P.F. 1994. Nitric oxide modulates cardiac and mast cell anaphylaxis. Agents Action 41 (Suppl), C89-C90.
19. A/Q inequalities in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 149, 1482-1487.
20. Pepke-Zaba, J., Higenbottam, T.W., Tuan Dinh-Xuan, A., Stone, D. & Wallwork, J. 1991. Inhaled nitric oxide as a cause of selective pulmonary vasodilation in pulmonary hypertension. Lancet 338, 1173-1174.
21. Persson, M.G., Friberg, S.G., Gustafsson, L.E. & Hedqvist, P. 1995. The promotion of the patent airways and inhibition of antigen-induced bronchial obstruction by endogenous nitric oxide. Br J Pharmacol 116, 2957-2962.
22. Powers, S.K., Dodd, S., Lawler, J. et al. 1988. Incidence of exercise-induced hypoxemia in elite endurance athletes at sea level. Eur J Appl Physiol 58, 298-302.
23. Préfaut, C., Anselme, F., Caillaud, C. & Masse,-Biron, J. 1994. Exercise-induced hypoxemia in older athletes. J Appl Physiol 76, 120-126.
24. Préfaut, C., Anselme-Poujol, F. & Caillaud, C. 1997. Inhibition of histamine release by nedocromil sodium reduces exercise-induced hypoxemia in master athletes. Med Sci Sports Exer 29, 10-16.
25. Reeves, J.T., Dempsey, J.A. & Grover, R.F. 1988. Pulmonary circulation during exercise. In: K. Weir & J.T. Reeves (eds) Lung Biology in Health and Disease. Pulmonary Vascular Physiology and Physiopathology, Vol. 38, pp. 107-133. Dekker, New-York.
26. Rehn, D., Reimann, H.J., Von der Ohe, M., Schmidt, U., Schmel, A. & Hennings, G. 1987. Biorhythmic changes of plasma histamine levels in healthy volunteers. Agents Actions 22, 24-29.
27. Rossaint, R., Falke, K.J., Lopez, F., Slama, K., Pison, U. & Zapol, W.M. 1993. Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med 328, 399-405.
28. Schafartzik, W., Arcos, J., Tsukimoto, K., Mathieu-Costello, O. & Wagner, P.D. 1993. Pulmonary interstitial edema in pig after heavy exercise. J Appl Physiol 75, 2535-2540.
29. A/Q distribution during heavy exercise and recovery in humans: implication for pulmonary edema. J Appl Physiol 72, 1657-1667.
30. Scherrer, U., Vollenweider, L., Delabays, A. et al. 1996. Inhaled nitric oxide for high-altitude pulmonary edema. N Engl J Med 334, 624-629.
31. Vervloet, D., Haddi, E., Tafforeau, M., Lanteaume, A., Kulling, G. & Charpin, D. 1991. Reliability of respiratory symptoms to diagnose atopy, Clin Exp Allergy 21, 733-737.
32. Wagner, P.D., Gale, G.E., Moon, R.E. et al. 1986. Pulmonary gas exchange in humans exercising at sea level and simulated altitude. J Appl Physiol 61, 260-270.
33. Warren, G.L., Cureton, K.J., Middendorf, W.F., Ray, C.A. & Warren, J.A. 1991. Red blood cell pulmonary capillary transit time during exercise in athletes. Med Sci Sports Exerc 23, 1353-1361.
34. West, J.B. & Mathieu-Costello, O. 1992. High altitude pulmonary edema is caused by stress failure of pulmonary capillaries. Int J Sports Med 13, S54-S58.
35. West, J.B., Tsukimoto, K., Mathieu-Costello, O. & Prediletto, R. 1991. Stress failure in pulmonary capillaries. J Appl Physiol 70, 1731-1742.
36. White, M.V., Slater, J.E. & Kaliner, M.A. 1987. Histamine and asthma. Am Rev Resp Dis 135, 1165-1176.