Lack of effect of spearmint on lower oesophageal sphincter function and acid reflux in healthy volunteers

Alimentary Pharmacology and Therapeutics

Volumn 13, Issue 6, 1999, Pages 805-812

  Bulat, R ^a   Fachnie, E ^a   Chauhan, U ^a   Chen, Ying ^a   Tougas, Gervais ^a  

^a MCMASTER UNIVERSITY MEDICAL CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PLANT EXTRACT; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ESOPHAGUS PH; FEMALE; GASTROESOPHAGEAL REFLUX; HUMAN; HUMAN EXPERIMENT; LOWER ESOPHAGUS SPHINCTER; LOWER ESOPHAGUS SPHINCTER PRESSURE; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PH ELECTRODE; PRIORITY JOURNAL; SPEARMINT; SYMPTOM;

ADOLESCENT; ADULT; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ESOPHAGOGASTRIC JUNCTION; FLAVORING AGENTS; GASTROESOPHAGEAL REFLUX; HUMANS; OILS, VOLATILE;

EID: 0033039660     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.1999.00528.x     Document Type: Article

References (16)

1. 1 Pittler MH, Ernst E. Peppermint oil for irritable bowel Syndrome: a critical review and metaanalysis. Am J Gastroenterol 1998; 93: 1131-5.
2. 2 Compendium of Pharmaceuticals and Specialties. Canadian Pharmaceutical Association, Ottawa, Ontario, Canada, 1998.
3. 3 Orlando RC. Reflux esophagitis, In: Yamada T, ed. Textbook of Gastroenterology. Philadelphia: Lippencott, 1995.
4. 4 Gunn JWC. The carminative action of volatile oils. J Pharmacol Exp Ther 1920; 16: 39-43.
5. 5 Plant OH, Miller CH. Effect of carminative volatile oils on the muscular activity of the stomach and colon, J Pharmacol Exp Ther 1926; 27: 149-56.
6. 6 Taylor BA, Luscombe DK, Duthie HL. Inhibitory effect of peppermint oil on gastrointestinal smooth muscle. Gut 1983; 24: A992(Abslract).
7. 7 Taylor BA, Luscombe DK, Duthie HL. Inhibitory effect of peppermint oil and menthol on human isolated coli. Gut 1984; 25; A1168-9.
8. 8 Taylor BA, Duthie HL, Luscombc DK. Calcium antagonist activity of menthol on gastrointestinal smooth muscle. Br J Clin Pharm 1985; 20: 293-4.
9. 9 Swandulla D, Schaefer K, Lux HD. Calcium channel current inactivation is selectively modulated by menthol. Neurosci Lett 1986; 68: 25-8.
10. 10 Swandulla D, Carbone E, Schaefer K, Lux HD. Effect of menthol on two types of Ca currents in cultured sensory neurons of vertebrates. Pfeugers Arch 1987; 409: 52-9.
11. 11 Hawthorne M, Ferrante J. Luchowski E, Rutledge A, Wei XY, Triggle DJ. The actions of peppermint oil and menthol on calcium channel dependent processes in intestinal, neuronal and cardiac preparations, Aliment Pharmacol Ther 1988; 2: 101-18.
12. 12 Hills JH, Aronson PI. The mechanism of action of peppermint oil on gastrointestinal smooth muscle; an analysis using patch clamp electrophysiology and isolated tissue pharmacology in rabbit and guinea-pig. Gastroenterology 1991; 101: 55-65.
13. 13 Creamer B. Oesophageal reflux and the action of carminatives. Lancet 1955; 1: 590-2.
14. 14 Sigmund CJ, McNally E. F The action of a carminative on the lower esophageal sphineter. Gastroenterology 1968; 56: 13-18.
15. 15 Martindale; The Extra Pharmacopia. London: Royal Pharmaceutical Society, 1996.
16. rd Edition. Bruce, LD, ed. Ottawa, Canada: Canadian Pharmacist Association. 1998.