Autocrine transforming growth factor-β from chronic lymphocytic leukemia-β cells interferes with proliferotive T cell signals

Immunobiology

Volumn 200, Issue 1, 1999, Pages 128-139

  Schuler, Martin ^a,c   Tretter, Theresa ^b   Schneller, Folker ^b   Huber, Christoph ^a   Peschel, Christian ^b  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CYTOKINE; INTERLEUKIN 2; INTERLEUKIN 4; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL PROLIFERATION; CHRONIC LYMPHATIC LEUKEMIA; CULTURE MEDIUM; CYTOKINE RELEASE; MINK; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0033039555     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0171-2985(99)80038-2     Document Type: Article

References (35)

1. FAGUET, G. B. 1994. Chronic lymphocytic leukemia: An updated review. J. Clin. Oncol. 12: 1974-1990.
2. O'BRIEN, S., A. DEL GIGLIO, and M. KEATING. 1995. Advances in the biology and treatment of B-cell chronic lymphocytic leukemia. Blood 85: 307-318, 1995.
3. GOTTARDI, D., A. ALFARANO, A. M. DE LEO, A. STACCHINI, L. BERGUI, and F. CALIGARIS CAPPIO. 1995. Defective apoptosis due to Bcl-2 overexpression may explain why B-CLL cells accumulate in GO. Curr. Top. Microbiol. Immunol. 194: 307-312.
4. COLLINS, R. J., L. A. VERSCHUER, B. V. HARMON, R. L. PRENTICE, J. H. POPE, and J. F. R. KERR. 1989. Spontaneous programmed cell death (apoptosis) of B-chronic lymphocytic leukaemia cells following their culture in vitro. Br. J. Haematol. 71: 343-349.
5. BANCHEREAU, J., and F. ROUSSET. 1991. Growing human B lymphocytes in the CD40 system. Nature 353: 678-679.
6. BANCHEREAU, J., P. DE PAOLI, A. VALLE, E. CARGIA, and F. ROUSSET. 1991. Long-term human B cell lines dependent on interleukin-4 and antibody to CD40. Science 251: 70-72.
7. FLUCKIGER, A. C., J. F. ROSSI, A. BUSSEL, P. BRYON, J. BANCHEREAU, and T. DEFRANCE. 1992. Responsiveness of chronic lymphocytic leukemia B cells activated via surface Igs or CD40 to B-cell tropic factors. Blood 80: 3173-3181.
8. RENARD, N., M. LAFAGE POCHITALOFF, I. DURAND, V. DUVERT, L. COIGNET, J. BANCHEREAU, and S. SAELAND. 1996. Demonstration of functional CD40 in B-lineage acute lymphoblastic leukemia cells in response to T-cell CD40 ligand. Blood 87: 5162-5170.
9. + T cells induce CD40-dependent proliferation of human B cell precursors. J. Immunol. 152: 1693-1701.
10. + T cells overcomes hyporesponsiveness of B-cell chronic lymphocytic leukemia in vitro. Cell. Immunol. 189: 41-50.
11. MASSAGUE, J. 1990. The transforming growth factor-beta family. Annu. Rev. Cell Biol. 6: 597-641.
12. LAWRENCE, D. A. 1996. Transforming growth factor-beta: a general review. Eur. Cytokine. Netw. 7: 363-374.
13. ALEXANDROW, M. G., and H. L. MOSES. 1995. Transforming growth factor beta and cell cycle regulation. Cancer Res. 55: 1452-1457.
14. BOUCHARD, C., W. H. FRIDMAN, and C. SAUTES. 1997. Effect of TGF-beta 1 on cell cycle regulatory proteins in LPS-stimulated normal mouse B lymphocytes. J. Immunol. 159: 4155-4164.
15. STAVNEZER, J. 1995. Regulation of antibody production and class switching by TGF-beta. J. Immunol. 154: 1647-1651.
16. SHULL, M. M., I. ORMSBY, A. B. KIER, S. PAWLOWSKI, R. J. DIEBOLD, M. YIN, R. ALLEN, C. SIDMAN, G. PROETZEL, D. CALVIN, et al. 1992. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359: 693-699.
17. KULKARNI, A. B., C. G. HUH, D. BECKER, A. GEISER, M. LYGHT, K. C. FLANDERS, A. B. ROBERTS, M. B. SPORN, J. M. WARD, and S. KARLSSON. 1993. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc. Natl. Acad. Sci. U.S.A. 90: 770-774.
18. KREMER, J.-P., G. REISBACH, C. NERL, and P. DÖRMER. 1992. B cell chronic lymphocytic leukaemia cells express and release transforming growth factor-beta. Br. J. Haematol, 80: 480-487.
19. LOTZ, M., E. RANHEIM, and T. J. KIPPS. 1994. Transforming growth factor beta as endogenous growth inhibitor of chronic lymphocytic leukemia B cells. J. Exp. Med. 179: 999-1004.
20. DOUGLAS, R. S., R. J. CAPOCASALE, R. J. LAMB, P. C. NOWELL, and J. S. MOORE. 1997. Chronic lymphocytic leukemia B cells are resistant to the apoptotic effects of transforming growth factor-beta. Blood 89: 941-947.
21. LAGNEAUX, L., A. DELFORGE, D. BRON, M. MASSY, M. BERNIER, and P. STRYCKMANS. 1997. Heterogenous response of B lymphocytes to transforming growth factor-beta in B-cell chronic lymphocytic leukaemia: Correlation with the expression of TGF-beta receptors. Br. J. Haematol. 97: 612-620.
22. CHOMCZYNSKI, P., and N. SACCHI. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159.
23. KASID, A., G. I. BELL, and E. P. DIRECTOR. 1988. Effects of transforming growth factor-beta on human lymphokine-activated killer cell precursors. Autocrine inhibition of cellular proliferation and differentiation to immune killer cells. J. Immunol. 141: 690-698.
24. ARDINGER, H. H., R. H. ARDINGER, G. I. BELL, and J. C. MURRAY. 1988. RFLP for the human transforming growth factor beta-1 gene (TGFB) on chromosome 19. Nucleic. Acids. Res. 16: 8202.
25. DECKER, T., T. FLOHR, P. TRAUTMANN, M. J. AMAN, W. HOLTER, O. MAJDIC, C. HUBER, and C. PESCHEL. 1995. Role of accessory cells in cytokine production by T cells in chronic B-cell lymphocytic leukemia. Blood 86: 1115-1123.
26. CERWENKA, A., D. BEVEC, O. MAJDIC, W. KNAPP, and W. HOLTER. 1994. TGF-beta 1 is a potent inducer of human effector T cells. J. Immunol. 153: 4367-4377.
27. HOLDER, M. J., K. KNOX, and J. GORDON. 1992. Factors modifying survival pathways of germinal center B cells. Glucocorticoids and transforming growth factor-beta, but not cyclosporin A or anti-CD19, block surface immunoglobulin-mediated rescue from apoptosis. Eur. J. Immunol. 22: 2725-2728.
28. + T cells. J. Immunol. 151: 2497-2510.
29. VAN KOOTEN, C., C. GAILLARD, J. P. GALIZZI, P. HERMANN, F. FOSIEZ, J. BANCHEREAU, and D. BLANCHARD. 1994. B cells regulate expression of CD40 ligand on activated T cells by lowering the mRNA level and through the release of soluble CD40. Eur. J. Immunol. 24: 787-792.
30. TSUBATA, T., J. WU, and T. HONJO. 1993. B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40. Nature 364: 645-648.
31. NAKAYAMA, K.-I., K. NAKAYAMA, L. B. DUSTIN, and D. Y. LOH. 1995. T-B cell interaction inhibits spontaneous apoptosis of mature lymphocytes in bcl-2 deficient mice. J. Exp. Med. 182: 1101-1110.
32. CLARK, E. A., and J. A. LEDBETTER. 1994. How B and T cells talk to each other. Nature 367: 425-428.
33. + T lymphocytes. J. Immunol. 152: 1523-1531.
34. CANTWELL, M., T. HUA, J. PAPPAS, and T. J. KIPPS. 1997. Acquired CD40-ligand deficiency in chronic lymphocytic leukemia. Nature Med. 3: 984-989.
35. LAGNEAUX, L., A. DELFORGE, C. DORVAL, D. BRON, and P. STRYCKMANS. 1993. Excessive production of transforming growth factor-beta by bone marrow stromal cells in B cell chronic lymphocytic leukemia inhibits growth of hematopoietic precursors and interleukin-6 production. Blood 82: 2379-2385.