Immune functions in the Fisher rat fed beluga whale (Delphinapterus leucas) blubber from the contaminated St. Lawrence estuary

Environmental Research

Volumn 80, Issue 2 II, 1999, Pages

  Lapierre, Patrice ^a   De Guise, Sylvain ^a   Muir, Derek C G ^b   Norstrom, Ross ^c   Béland, Pierre ^d   Fournier, Michel ^a,e,f  

^a UNIVERSITÉ DU QUÉBEC À MONTRÉAL   (Canada)

^b FRESHWATER INSTITUTE   (Canada)

^c ENVIRONMENT CANADA   (Canada)

^d Institut National Decotoxicologie Du Saint Laurent Montreal   (Canada)

^e INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE   (Canada)

^f FISHERIES AND OCEANS CANADA   (Canada)

Author keywords

Beluga whale blubber; Immunotoxicology; Organochlorine; Rat

Indexed keywords

DIOXIN; FURAN DERIVATIVE; ORGANOHALOGEN DERIVATIVE;

ANIMAL CELL; CONFERENCE PAPER; CONTROLLED STUDY; DIETARY INTAKE; ESTUARY; FOOD CONTAMINATION; IMMUNOPHENOTYPING; IMMUNOTOXICITY; LYMPHOCYTE TRANSFORMATION; NATURAL KILLER CELL; NONHUMAN; PHAGOCYTOSIS; PLAQUE FORMING CELL; PRIORITY JOURNAL; RAT; RESPIRATORY BURST; WATER POLLUTION; WHALE;

DELPHINAPTERUS LEUCAS;

EID: 0033039401     PISSN: 00139351     EISSN: None     Source Type: Journal    
DOI: 10.1006/enrs.1998.3942     Document Type: Conference Paper

References (38)

1. Andersson, L., Nikolaidis, E., Brunstrom, B., Bergman, A., and Dencker, L. (1991). Effects of polychlorinated biphenyls with Ah receptor affinity on lymphoid development in the thymus and the bursa of Fabricius chick embryos in ovo. Toxicol. Appl. Pharmacol. 107, 183-188.
2. Arnold, D. L., Bryce, F., Karpinski, K., Mes, J., Fernie, S., Tryphonas, H., Truelove, J., McGuire, P. F., Burns, D., and Tanner, J. R. (1993). Toxicological consequences of Aroclor 1254 ingestion by female rhesus (Macaca mulatto) monkeys. Part 1B. Prebreeding phase: Clinical and analytical laboratory. Food Chem. Toxicol. 31, 811-824.
3. Biagini, R. E., Henningsen, G. M., MacKenzie, B., Sanderson, W. T., Robertson, J., and Baumgardner, E. S. (1993). Evolution of acute immunotoxicity of alachlor in male F344/N rats. Bull. Environ. Contam. Toxicol. 50, 266-268.
4. Chang, L., Gusewitch, G. A., Chritton, D. B. W., Folz, J. C., Lebeck, L. K., and Nehlsen-Cannarella, S. L. (1993). Rapid flow cytometric assay for the assessment of natural killer cell activity. J. Immunol. Methods 116, 45-54.
5. Davis, D., and Safe, S. (1988). Immunosuppressive activities of polychlorinated dibenzofuran congeners: Quantitative structure-activity relationship and interactive effects. Toxicol. Appl. Pharmacol. 94, 141-149.
6. De Guise, S., Lagacé, A., and Béland, P. (1994a). Tumors in St. Lawrence beluga whales (Delphinapterus leucas). Vet. Pathol. 31, 444-449.
7. De Guise, S., Lagacé, A., and Béland, P. (1994b). Gastric papillomas in eight St. Lawrence beluga whales (Delphinapterus leucas). J. Vet. Diag. Invest. 6, 385-388.
8. De Guise, S., Lagacé, A., Béland, P., Girard, C., and Higgins, R. (1995a). Non-neoplastic lesions in beluga whales (Delphinapterus leucas) and other marine mammals from the St. Lawrence Estuary. J. Comp. Pathol. 112, 257-271.
9. De Guise, S., Martineau, D., Béland, P., and Fournier, M. (1995b). Possible mechanisms of action of environmental contaminants on St. Lawrence beluga whales (Delphinapterus leucas). Environ. Health Persp. 103(Suppl 4), 73-77.
10. Descotes, J. (1988). "Immunotoxicology of Drugs and Chemicals." Elsevier, Amsterdam.
11. Durham, S. K. and Brouwer, A. (1990). 3,4,3′,4′-tetrachlorobiphenyl distribution and induced effects in the rat adrenal gland. Localization in the zona fasciculata. Lab. Invest. 62, 232-239.
12. Exon, J. H., Talcott, P. A., and Koller, L. D. (1985). Effect of lead, polychlorinated biphenyls and cyclophospha-mide in rat natural killer cells, interleukin 2, and antiboty synthesis. Fundam. Appl. Toxicol. 5, 158-164.
13. Ford, C. A., Muir, D. C. G., Norstrom, R. J., Simon, M., and Mulvihill, M. J. (1993). Development of a semi-automated method for non-ortho PCBs: Application to Canadian artic marine mammal tissues. Chemosphere 26, 1981-1991.
14. Friend, M. and Trainer, D. O. (1970). Polychlorinated biphenyl: Interaction with duck hepatitis virus. Science 170, 1314-1316.
15. Imanishi, J., Nomura, H., Matsubara, M., Kita, M., Won, S.-J., Mizutani, T., and Kishida, T. (1980). Effect of polychlo-rinated biphenyl on viral infections in mice. Infect. Immun. 29, 275-277.
16. Kerkvliet, N. I., Baecher-Steppan, L., Smith, B. B., Youngberg, J. A., Henderson, M. C., and Buhler, D. R. (1990). Role of the Ah locus in suppression of cytotoxic T lymphocyte activity by halogenated aromatic hydrocarbons (PCBs and TCDD): Structure-activity relationships and effects in C57B1/6 mice congenic at the Ah locus. Fundam. Appl. Toxicol. 14, 532-541.
17. Letcher, R. J., Norstrom, R. J., and Bergman, A. (1995). An integrated analytical method for determination of polychlorinated aryl methyl sulfone metabolites and polychlorinated hydrocarbon contaminants in biological matrices. Anal. Chem. 67, 4155-4163.
18. Loose, L. D., Pittman, K. A., Benitz, K-F., and Silkworth, J. B. (1977). Polychlorinated biphenyl and hexachloro-benzene induced tumoral immunosuppression. J. Reticuloendothel. Soc. 22, 253-271.
19. Loose, L. D., Pittman, K. A., Benitz, K.-F., Silkworth, J. B., Mueller, W., and Coulston, F. (1978). Environmental chemical-induced immune dysfunction. Ecotoxicol. Environ. Saf. 2, 173-198.
20. Martineau, D., Béland, P., Desjardins, C., and Lagacé, A. (1987). Levels of organochlorine chemicals in tissue of beluga whales (Delphinapterus leucas) from the St. Lawrence Estuary, Québec, Canada. Arch. Environ. Contam. Toxicol. 16, 137-147.
21. Martineau, D., Lagacé, A., Béland, P., Higgins, R., Armstrong, D., and Shugart, L. R. (1988). Pathology of stranded beluga whales (Delphinapterus leucas) from the St. Lawrence estuary, Québec, Canada. J. Comp. Pathol. 98, 287-311.
22. Martineau, D., De Guise, S., Fournier, M., Shugart, L., Girard, C., Lagacé, A., and Béland, P. (1994). Pathology and toxicology of beluga whales from the St. Lawrence estuary, Quebec, Canada-past, present and future. Sci. Total Environ. 154, 201-215.
23. McMurry, S. T., Lochmiller, R. L., Vestey, M. R., Qualls, C. W., Jr., and Elarybam, C. S. (1991). Acute effects of benzene and cyclophosphamide exposure on cellular and humoral immunity of cotton rats, Sigmodon hispidus. Bull. Environ. Contam. Toxicol. 46, 937-939.
24. Michaud, R. (1993). Distribution estivale du béluga du Saint-Laurent; synthèse de 1986 à 1992. Can. Tech. Rep. Aquat. Sci. No 1906, 28 + vi p.
25. Muir, D. C. G., Ford, C. A., Stewart, R. E. A., Smith, T. G., Addison, R. F., Zinck, M. E., and Béland, P. (1990). Organochlorine contaminants in belugas, Delphinapterus leucas, from Canadian waters. Can. Bull. Fish. Aquat. Sci. 224, 165-190.
26. Muir, D. C. G., Segstro, M. D., Hobson, K. A., Ford, C. A., Stewart, R . E. A., and Olpinski, S. (1995). Can seal eating explain the elevated level of PCBs and organochlorine pesticides in walrus blubber from eastern Hudson Bay (Canada). Environ. Pollut. 90, 335-348.
27. Pippard, L. (1985). Status of the St. Lawrence River population of beluga (Delphinapterus leucas). Can. Field-Natur. 99, 438-450.
28. Poland, A. and Knutson, J. C. (1982). 2,3,7,8,-Tetrachlorodibenzo-p-dioxin and related halogenated hydrocarbons: Examination of the mechanism of toxicity. Annu. Rev. Pharmacol. Toxicol. 22, 517-554.
29. Reeves, R. R. and Mitchell, E. (1984). Catch history and initial population of white whales (Delphinapterus leucas) in the river and gulf of St. Lawrence, eastern Canada. Naturaliste-Can. 111, 63-121.
30. Rice, C. D., Merchant, R. E., Jeong, T. C., Karras, J. B., and Holsapple, M. P. (1995). The effects of acute exposure to 2,3,7,8-tetrachlorodibenzo-r-dioxin on glioma-specific cytotoxic T-cell activity in Fischer 344 rats. Toxicology 95, 177-185.
31. Ross, P. S. (1995). Seals, pollution and disease: Environmental contaminant-induced immunosuppression. submitted, 176 pp.
32. Shigematsu, N., Norimatsu, Y., Ishibashi, T., Yoshida, M., Suetsuga, S., Kawatsu, T., Ikeda, T., Saito, R., Ishimaru, S., Shirakusa, T., Kido, M., Emori, K, and Toshimitsu, H. (1971). Clinical and experimental studies on impairment of respiratory organs in chlorobiphenyl poisoning. Fukuoka Acta Med. 62, 150.
33. Smialovicz, R. J., Andrews, J. E., Riddle, M. M., Rodgers, R. R., Loebke, R. W., and Copeland, C. B. (1989). Evaluation of immunotoxicity of low level PCB exposure in the rat. Toxicology 56, 197-211.
34. Thomas, P. T. and Hinsdill, R. D. (1978). Effects of polychlorinated biphenyls on the immune response of rhesus monkeys and mice. Toxicol. Appl. Pharmacol. 44, 41-51.
35. Tryphonas, H., Hayward, S., O'Grady, L., Loo J. C. K, Arnold, D. L., Bryce, F., and Zawidzka, Z. Z. (1989). Immuno-toxicity studies of PCB (Aroclor 1254) in the adult rhesus (Macaca mulatto) monkey - Preliminary report. Int. J. Immunopharmacol. 11, 199-206.
36. Wagemann, R., Stewart, R. E. A., Béland, P., and Desjardins, C. (1990). Heavy metals and selenium in tissues of beluga whales, Delphinapterus leucas, from the Canadian Arctic and St. Lawrence estuary. Can. Bull. Fish. Aquat. Sci. 224, 191-206.
37. Wasserman, D., Wasserman, M., Cucos, S., and Djavaherian, M. (1993). Function of adrenal gland zona fasciculata in rats receiving polychlorinated biphenyls. Environ. Res. 6, 334-338.
38. White, K. L., Lysy, H., McCoy, J. A., and Anderson, A. C. (1986). Modulation of serum complement levels following exposure to polychlorinated dibenzo-p-dioxins. Toxicol. Appl. Pharmacol. 84, 209-219.