Synthesis of 3-alkenyl-Δ3-cephems via sequential reductive 1,2- elimination/ addition/cyclization in an alkenyltin/copper(I) chloride/bpy system

Synlett

Volumn , Issue 6, 1999, Pages 774-776

  Tanaka, Hideo ^a   Tokumaru, Yoshihisa ^a   Torii, Sigeru ^a,b  

^a OKAYAMA UNIVERSITY   (Japan)

^b Institute of Creative Chemistry Co   (Japan)

Author keywords

3,4 disubstituted butenoate; 3 alkeyl 3 cephems; Addition cyclization; Alkenyltin CuCl system; Reductive 1,2 elimination

Indexed keywords

ALKENYL GROUP; CEPHEM DERIVATIVE; COPPER CHLORIDE; COPPER COMPLEX; ORGANOTIN COMPOUND; PENICILLIN G;

ARTICLE; CYCLIZATION; DRUG DEVELOPMENT; REDUCTION; SYNTHESIS;

EID: 0033039215     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1999-2735     Document Type: Article

References (25)

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24. The allenecarboxylate 2 can be stored in a refrigerator for several days without appreciable change. However, it gradually decomposes under ambient conditions, particularly in the presence of a trace amount of acid or base.
25. H. Tanaka, S. Sumida, Y. Nishioka, N. Kobayashi, Y. Tokumaru, Y. Kameyama and S. Torii, J. Org. Chem., 1997, 62, 3610.