New synthesis of substituted 2-carboxyindole derivatives: Versatile introduction of a carbamoylethynyl moiety at the C-3 position

Archiv der Pharmazie

Volumn 332, Issue 2, 1999, Pages 55-58

  Hewkin, Cheryl T ^a   Di Fabio, Romano ^a   Conti, Nadia ^a   Cugola, Alfredo ^a   Gastaldi, Paola ^a   Micheli, Fabrizio ^a   Quaglia, Anna M ^a  

^a GSK   (Italy)

Author keywords

Glycine antagonists; Neuroprotection; NMDA receptor

Indexed keywords

4,6 DICHLORO 3 PHENYLCARBAMOYLETHYNYLINDOLE 2 CARBOXYLIC ACID; ANTICONVULSIVE AGENT; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; UNCLASSIFIED DRUG;

AMIDATION; ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; DRUG BINDING SITE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROLYSIS; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICONVULSANTS; BINDING SITES; GLYCINE; INDOLES; MALE; MICE; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033037611     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4184(19993)332:2<55::AID-ARDP55>3.0.CO;2-Z     Document Type: Article

References (11)

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11. 6.8 = 2 Hz.