Dosmalfate. Cytoprotectant

Drugs of the Future

Volumn 24, Issue 4, 1999, Pages 381-385

  Orjales, A ^a  

^a FAES SA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM DERIVATIVE; DOSMALFATE; MISOPROSTOL; PEPSIN A; PLACEBO; PROSTAGLANDIN; RANITIDINE; UNCLASSIFIED DRUG;

CELL PROTECTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIARRHEA; DIGESTIVE SYSTEM ULCER; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG URINE LEVEL; HUMAN; INTRADUODENAL DRUG ADMINISTRATION; ORAL DRUG ADMINISTRATION; PHASE 1 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; REVIEW; STOMACH PH;

EID: 0033036157     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.1999.024.04.531962     Document Type: Review

References (35)

1. Orjales, A., Mosquera, R. (FAES, S.A.). New sulfated diosmin deriv. US 5296469.
2. Mosquera, R., Labeaga, L., Orjales, A. New diosmin derivative with cytoprotective activity. II Congresso Congiunto Italiano-Spagnolo di Chimica Farmaceutica (Aug 30-Sept 3, Ferrara) 1995, Abst 22.
3. NIH Consensus Development Panel on Helicobacter pylori in Peptic Ulcer Disease. Helicobacter pylori in peptic ulcer disease. JAMA-J Am Med Assoc 1994, 272: 65-9.
4. Fries, J.F. NSAID gastropathy: Epidemiology. J Musculoskelet Med 1991, 8: 21-8.
5. Rees, W.D.W. Prevention of peptic ulcer relapse by sucralfate: Mechanisms of action. Scand J Gastroenterol 1992, 27(Suppl. 191): 4-6.
6. Griffin, M.R., Piper, J.M., Daugherty, J.R., Snowden, M., Ray, W.A. Nonsteroidal anti-inflammatory drug use increases risk of peptidic ulcer disease in elderly persons. Ann Intern Med 1991, 114: 257-63.
7. Beard, K., Walker, A.M., Perera, D.R., Jik, H. Non-steroidal anti-inflammatory drugs and hospitalisation for gastroesophageal bleeding in the elderly. Arch Intern Med 1987, 147: 1621-3.
8. Carson, J.L., Strom, B.L., Soper, K.A., West, S.L., Morse, M.L. The association of nonsteroidal anti-inflammatory drugs with upper gastrointestinal tract bleeding. Arch Intern Med 1987, 147: 85-8.
9. MacDonald, T.M., Morant, S.V., Robinson, G.C., Shield, M.J., McGilchrist, M.M., Murray, F.E., McDevitt, D.G. Association of upper gastrointestinal toxicity of non-steroidal anti-inflammatory drugs with continued exposure: Cohort study. BMJ - Br Med J 1997, 315: 1333-7.
10. Vane, J. Toward a better aspirin. Nature 1994, 367: 215-6.
11. Champion, G.D., Feng, P.H., Azuma, T. et al. NSAID-induced gastrointestinal damage. Epidemiology, risk and prevention, with an evaluation of the role of misoprostol. Ar Asia-Pacific perspective and consensus. Drugs 1997, 53: 6-19.
12. Silverstein, F.E., Graham, D.Y., Senior, J.R. et al. Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal antiinflammatory drugs. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 1995, 123: 241-9.
13. Graham, D.Y., Agrawal, N.M., Roth, S.H. Prevention of NSAID-induced gastric ulcer with misoprostol: Multicenter, double-blind, placebo controlled trial. Lancet 1988, 2: 1277-80.
14. Raskin, J.B., White, R.H., Jaszewski, R. et al. Misoprostol and ranitidine in the prevention of NSAID-induced ulcers: A prospective, double-blind multicenter study. Am J Gastroenterol 1996, 91: 223-7.
15. Dajani, E.Z., Wilson, D.E., Agrawal, N.M. Prostaglandins: An overview of the worldwide clinical experience. J Assoc Acad Minor Phys 1991, 2: 23, 27-35.
16. Raskin, J.B., White, R.H., Jackson, J.E. et al. Misoprostol dosage in the prevention of nonsteroidal anti-inflammatory drug-induced gastric and duodenal ulcers. A comparison of three regimens. Ann Intern Med 1995, 123: 344-50.
17. Shay, H., Komarov, S.A., Fels, S.S., Meranze, D., Gruenstein, M., Siplet, H. A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology 1945, 5: 43-61.
18. Gil-Sánchez, J.C., Labeaga, L., Orjales, A. Dosmalfate: A new cytoprotective agent. Methods Find Exp Clin Pharmacol 1995, 17(Suppl. A): 55.
19. Nakamura, K., Ozawa, Y., Furuta, Y., Miyazaki, H. Effects of sodium polyacrilate (PaNa) on acute esophagitis by gastric juice in rats. Jpn J Pharmacol 1982, 32: 445-56.
20. Labeaga, L., Corcóstegui, R., Mosquera, R., Orjales, A. Effect of dosmalfate on several experimental gastric mucosal damages in the rat. 14th Int Symp Med Chem (Sept 8-12, Maastricht) 1996, Abst P-3.15.
21. Okabe, S., Takagi, K., Inoue, K. Effect of NC-1300-O-3 on healing of acetic acid-induced gastric ulcers in rats. Jpn J Pharmacol 1993, 62: 25-33.
22. Labeaga, L., Orjales, A. Activity of F-3616 on the process of spontaneous healing of ulcer induced by submucosal injection of acetic acid in the stomach of rats. FAES Research Department, data on file.
23. Wilson, T.R., Whittaker, D.K. Ulceration of oral and gastric mucosa produced by stress in rats. Scand J Gastroenterol 1969, 4: 17-24.
24. Algate, D.R., Munt, P.L., Adams, A.R. F-3616 effects on the rate of healing of restraint-induced gastric damage in the rat. Huntindon Life Sciences, Huntingdon 1987. FAES Research Department, data on file.
25. Lucero, M.L., Orjales, A. Dosmalfate: Pharmacokinetic study in the rat. FAES Research Department, data on file.
26. Lucero, M.L., Valiente, R., Torrent, J., Bayés, M.C., Gich, I. Dosmalfate: Pharmacokinetic study in man. Hospital de la Santa Cruz y San Pablo, Barcelona, and FAES Research Department, data on file.
27. Arteche, J.K., López, C., Orjales, A. Dosmalfate: Toxicity studies in rodents. FAES Research Department, data on file.
28. Zapatero, J., Casadesús, A., Palou, F. Dosmalfate: Toxicity studies in dogs. CIDA, Barcelona 1990. FAES Research Department, data on file.
29. FAES Research Department, data on file.
30. Torrent, J., Bayés, M.C., Gich, I. Study of the tolerance of dosmalfate after oral administration of increasing single doses to healthy volunteers. Hospital de la Santa Cruz y San Pablo, Barcelona 1990. FAES Research Department, data on file.
31. Barbanoj, M.J., Bayés, M.C., Gich, I. Study of the tolerance of dosmalfate after oral administration of multiple doses to healthy volunteers. Hospital de la Santa Cruz y San Pablo, Barcelona 1991. FAES Research Department, data on file.
32. Le Kerneau, J., Gompel, H., Sorkine, M., Gilton, A., González-Dunia, J. Comparison of the pharmacological activity of three doses of dosmalfate with placebo on the protection of gastric mucosa after a single dose of aspirin. Unité Clinique I.T.E.M.-Phase I. Fondation Edmond de Rothschild pour la Recherche Apliquée en Médecine. Paris 1992. FAES Research Department, data on file.
33. Velo, J.L., Cos, E., Pérez Piqueras, J., Silva, C., Saez, M.A., Cano, J.M., Prieto, M. Multicenter randomised double-blind study of efficacy and tolerance of three doses of dosmalfate against placebo in healing duodenal ulcer. Hospital Universitario Gregorio Marañón, Hospital del Aire and Hospital La Paz, Madrid 1993. FAES Research Department, data on file.
34. Cohen de Lara, A., Gompel, H. et al. Comparative study of the clinical and endoscopic efficacy and safety of dosmalfate versus misoprostol in the prevention of gastric ulcer induced by non-steroidal antiinflammatory drugs (NSAIDs). Multicentric Clinical Study, France 1995. FAES Research Department, data on file.
35. Navarro, F., Valiente, R. et al. Comparison of the efficacy and tolerability of dosmalfate and misoprostol in the prevention of nonsteroidal anti-inflammatory drug-induced gastric and duodenal ulcers. Multicentric clinical study, Spain 1998. FAES Research Department, data on file.