Targeted cleavage of RNA molecules by human RNase P using minimized external guide sequences

Antisense and Nucleic Acid Drug Development

Volumn 9, Issue 1, 1999, Pages 81-88

  Werner, Martina ^a,b   Rosa, Eddie ^a   Emran, Obaidullah A L ^a   Goldberg, Allan R ^a   George, Shaji T ^a  

^a Innovir Laboratories Inc   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RIBONUCLEASE P; TYROSINE TRANSFER RNA;

ANTICODON; ARTICLE; HUMAN; HUMAN CELL; MUTATION; PRIORITY JOURNAL; RNA CLEAVAGE; RNA SEQUENCE;

EID: 0033035303     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1999.9.81     Document Type: Article

References (13)

1. ALTMAN, S. (1993). RNA enzyme-directed gene therapy. Proc. Natl. Acad. Sci. USA 90, 10898-10900.
2. ALTMAN, S. (1995). RNase P in research and therapy. Bio/Technology 13, 327-329.
3. BARTKIEWIECZ, M., GOLD, H., and ALTMAN, S. (1989). Identification and characterization of an RNA molecule that co-purifies with RNase P activity from HeLa cells. Genes Dev. 3, 488-499.
4. CARRARA, G., CALANDRA, P., FRUSCOLONI, P., DORIA, M., and TOCCHINI-VALENTINI, G.P. (1989). Site selection by Xenopus laevis RNase P. Cell 58, 37-45.
5. CONRAD, F., HANNE, A., GAUR, R.K., and KRUPP, G. (1995). Enzymatic synthesis of 2′ modified nucleic acids: Identification of important phosphates and ribose moieties in RNase P substrates. Nucleic Acids Res. 23, 1845-1853.
6. FORSTER, A.C., and ALTMAN, S. (1990). External guide sequences for an RNA enzyme. Science 249, 783-786.
7. GAUR, R.K., HANNE, A., CONRAD, F., KAHLE, D., and KRUPP, G. (1996). Differences in the interaction of Escherichia coli RNase P with tRNAs containing a short or long extra arm. RNA 2, 674-681.
8. GUERRIER-TAKADA, C., LI, Y., and ALTMAN, S. (1995). Artificial regulation of gene expression in Escherichia coli by RNase P. Proc. Natl. Acad. Sci. USA 92, 11115-11119.
9. GUERRIER-TAKADA, C., LUMELSKY, N., and ALTMAN, S. (1987). Specific interactions in RNA enzyme-substrate complexes. Science 246, 1578-1584.
10. GUERRIER-TAKADA, C., McCLAIN, W.H., and ALTMAN, S. (1984). Cleavage of tRNA precursors by the RNA subunit of E. coli ribonuclease P (M1 RNA) is influenced by 3′ proximal CCA in the substrates. Cell 38, 219-224.
11. HARDT, W.D., SCHLEGL, J., ERDMANN, V.A., and HARTMANN, R.K. (1993). Role of the D arm and anticodon stem in tRNA. Recognition by eubacterial and eukaryotic RNase P enzyme. Biochemistry 32, 13046-13053.
12. YUAN, Y., and ALTMAN, S. (1995). Substrate recognition by human RNase P: Identification of small model substrates for the enzyme. EMBO J. 14, 159-168.
13. YUAN, Y., HWANG, E.S., and ALTMAN, S. (1992). Targeted cleavage of mRNA by human RNase P. Proc. Natl. Acad. Sci. USA 89, 8006-8010.