The low potential for drug interactions with zanamivir

Clinical Pharmacokinetics

Volumn 36, Issue SUPPL. 1, 1999, Pages 41-50

  Daniel, Mick J ^a   Barnett, Jacqueline M ^a   Pearson, Bridget A ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; AMOXICILLIN PLUS CLAVULANIC ACID; BUFURALOL; CHLORZOXAZONE; COUMARIN; CYTOCHROME P450; ETHOXYRESORUFIN; IBUPROFEN; MEPHENYTOIN; MIDAZOLAM; OXYMETAZOLINE; PARACETAMOL; PHENACETIN; PHENYLEPHRINE; PLASMA PROTEIN; PROMETHAZINE; TOLBUTAMIDE; ZANAMIVIR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG METABOLISM; DRUG POTENCY; DRUG PROTEIN BINDING; ENZYME INHIBITION; ERYTHROCYTE; FEMALE; HUMAN; HUMAN TISSUE; INTRAVENOUS DRUG ADMINISTRATION; LIVER METABOLISM; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VIRUS REPLICATION;

EID: 0033034362     PISSN: 03125963     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003088-199936001-00005     Document Type: Article

References (11)

1. 1. Sadeque AJM, Eddy AC, Meier GP, et al. Stereoselective sulfoxidation by human flavin-containing monooxygenase: evidence for catalytic diversity between hepatic, renal and fetal forms. Drug Metab Dispos 1992; 20: 832-9
2. 2. Herriott D, Fenton DNM, Bayliss MK. The validation of Western blot analysis of rat microsomes. Ware: Glaxo Wellcome, WBP/94/043
3. 3. Woods JM, Bethell RC, Coates JAV, et al. 4-Guanidino-2,4 dideoxy-2,3-dehydro-N-acetylneuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of the growth of a wide range of influenza A and B viruses in vitro. Antimicrob Agents Chemother 1993; 37 (7): 1473-9
4. 4. Cass LMR, Efthymiopoulos C, Bye A. Pharmacokinetics of zanamivir after intravenous, oral, inhaled or intranasal administration to healthy volunteers. Clin Pharmacokinet 1999; 36 Suppl. 1: 1-11
5. 5. Okey AB. Enzyme induction in the cytochrome P-450 system. Pharmacol Ther 1990; 4: 241-98
6. 6. Sukai H, Pank SS, Kikkawa Y. Differential oxidase activity of hepatic pulmonary microsomal cytochrome P-450 isoenzymes after treatment with cytochrome P-450 inducers. Biochem Biophys Res Commun 1992; 187: 1262-9
7. 7. Koch-Weser J, Sellers EM. Binding of drugs to serum albumin. N Engl J Med 1976; 294 (10): 526-31
8. 8. American Hospital Formulary Drug Information 90. In: McEvoy GK, editor. American Society of Hospital Pharmacists. Bethesda, MD: 1990
9. 9. Miller DK, Lenard J. Antihistamines, local anesthetics and other amines as antiviral agents, Proc Natl Acad Sci USA 1981; 78: 3605-9
10. 10. Hsyu P, Hussey BK. Renal disposition and drug screening of GR121167X (GG167) in the isolated perfused rat kidney. Research Triangle Park: Glaxo Wellcome report RM1996/ 00072/00
11. 11. Peng A, Hussey B. Population pharmacokinetics of zanamivir (protocols NAIA 2005 and NAIA 2006) including combined phase I and II study analysis. Research Triangle Park, NC, USA: Glaxo Wellcome, RM 1996/0060/00