Indomethacin-induced gastric antral damage in hamsters: Are neutrophils involved?

Alimentary Pharmacology and Therapeutics

Volumn 13, Issue 2, 1999, Pages 195-202

  Fitzpatrick, L R ^a   Sakurai, K ^a   Le, T ^a  

^a OTSUKA PHARMACEUTICAL DEVELOPMENT AND COMMERCIALIZATION INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INDOMETACIN; METHOTREXATE; MYELOPEROXIDASE; NEUTROPHIL CYTOPLASMIC ANTIBODY; REBAMIPIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; ENZYME ACTIVITY; HAMSTER; HISTOPATHOLOGY; INTRAGASTRIC DRUG ADMINISTRATION; MALE; NEUTROPENIA; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; STOMACH ANTRUM; STOMACH INJURY;

ALANINE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CRICETINAE; GASTRIC MUCOSA; INDOMETHACIN; MALE; MESOCRICETUS; METHOTREXATE; MICE; NEUTROPHILS; PEROXIDASE; PYLORIC ANTRUM; QUINOLONES;

EID: 0033034156     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.1999.00444.x     Document Type: Article

References (22)

1. Wallace JL, Keenan CM, Granger DN. Gastric ulceration induced by non-steroidal anti-inflammatory drugs is a neutrophil dependent process. Am J Physiol 1990; 259: G462-7.
2. Lee M, Aldred K, Lee E, et al. Aspirin-induced acute gastric mucosal injury is a neutrophil dependent process. Am J Physiol 1992; 263: G920-6.
3. Wallace JL, Arfors KE, McKnight GW. A monoclonal antibody against the CD18 leukocyte adhesion molecule prevents indomethacin induced gastric damage in the rabbit. Gastroenterology 1991; 100: 878-83.
4. Trevethick MA, Clayton NM, Bahl AK, et al. Neutrophil depletion does not prevent indomethacin-induced ulceration of the rat gastric antrum. Agents Actions 1994; 41: C226-7.
5. Trevethick MA, Bahl AK, Clayton NM, et al. Neutrophil infiltration does not contribute to the ulcerogenic effects of indomethacin in the rat gastric antrum. Agents Actions 1994; 43: 39-43.
6. Whiteley LO, Erickson A, Smith B. NSAID-induced gastric injury in rats; where are the neutrophils? A histologic study. Gastroenterology 1995; 108: A258(Abstract).
7. Kolbasa KP, Lancaster C, Olafsson AS. Indomethacin-induced gastric antral ulcers in hamsters. Gastroenterology 1988; 95: 9 5: 932-44.
8. Fitzpatrick LR. Protection by acidified maalox against indomethacin induced gastric antral ulceration in hamsters. Digestion 1991; 50: 1-6.
9. Kuratani K, Yamazaki M, Kodama H, et al. Possible involvement of hyperinsulinemia and adrenergic activation in the pathogenesis of indomethacin-induced antral ulcers in nonfasted hamsters and refed rats. J Pharmacol Exp Ther 1992; 263: 951-5.
10. Fitzpatrick LR, Ebert TL. Indomethacin induced gastric antral damage in hamsters: no correlation with hypoglycemia or lipid peroxidation. Gastroenterology 1997; 112: A117(Abstract).
11. Murakami K, Okajima K, Uchiba M, et al. Rebamipide attenuates indomethacin-induced gastric mucosal lesion formation by inhibiting activation of leukocytes in rats. Dig Dis Sci 1997; 42: 319-25.
12. Kim CD, Hong KW. Preventive effect of rebamipide on gastric lesions induced by ischemia-reperfusion in the rat. J Pharmacol Exo Ther 1995; 275: 340-4.
13. Suzuki K, Ota H, Sasagawa S, et al. Assay for myeloperoxidase in human polymorphonuclear leukocytes. Anal Biochem 1983; 132: 345-52.
14. Santucci L, Fiorucci S, Di Matteo FM, et al. Role of tumor necrosis factor α release and leukocyte margination in indomethacin-induced gastric injury in rats. Gastroenterology 1995; 108: 393-401.
15. Takeuchi K, Takehara K, Ohuchi T. Diethyldithiocarbamate, a superoxide dismutase inhibitor, reduces indomethacin-induced gastric lesions in rats. Digestion 1996; 57: 201-9.
16. Lichtenberger LM, Wang ZM, Romero JJ. et al. Non-steroidal anti-inflammatory drugs (NSAIDs) associate with zwitterionic phospholipids: insight into the mechanism and reversal of NSAID induced gastrointestinal injury. Nat Med 1995; 1: 154-8.
17. Saita H, Murakami M, Dekiga H, et al. Protective effect of rebamipide against the development of ammonia-induced gastric mucosal injury in ischemic rats. Gastroenterology 1996; 110: A247(Abstract).
18. Moncada S, Palmer R, Higgs E. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 1991; 4: 109-42.
19. Donnelly MT, Stack WA, Courtaud EM, et al. Nitric oxide donating flurbiprofen (HCT 1026) causes less endoscopic damage in healthy volunteers than flurbiprofen. Gut 1998; 42(Suppl.1): A6(Abstract).
20. Takeuchi K, Uwaka H, Konaka A. Effect of nitric-oxide releasing aspirin derivative on gastric functional and ulcerogenic responses in rats: comparison with plain aspirin. J Pharmacol Exp Ther 1998; 286: 115-21.
21. Higa A, Eto T, Nawa Y. Evaluation of the role of neutrophils in the pathogenesis of acetic acid-induced colitis in mice. Scand J Gastroenterol 1997; 32: 564-8.
22. Tepperman BL, Vozollo BL, Soper BD. Effect of neutropenia on gastric mucosal integrity and mucosal nitric oxide synthesis in the rat. Dig Dis Sci 1993; 38: 2056-61.