Influence of albumin infusion on the urinary excretion of β2-microglobulin in patients with proteinuria

Nephron

Volumn 81, Issue 3, 1999, Pages 329-333

  Branten, Amanda J W ^a   Wetzels, Jack F M ^b  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NONE

Author keywords

2 microglobulin; Albumin infusion; Competitive mechanism; Glomerular diseases; Proteinuria; Tubular reabsorption process

Indexed keywords

4 AMINOHIPPURIC ACID; ALBUMIN; BETA 2 MICROGLOBULIN; IMMUNOGLOBULIN G; INULIN; TRANSFERRIN;

4 AMINOHIPPURIC ACID CLEARANCE; ADULT; ARTICLE; BETA 2 MICROGLOBULIN URINE LEVEL; BLOOD PRESSURE; CLINICAL ARTICLE; CONTROLLED STUDY; GLOMERULOPATHY; GLOMERULUS FILTRATION RATE; HEMODILUTION; HUMAN; INFUSION; INULIN CLEARANCE; KIDNEY PLASMA FLOW; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE DAMAGE; PRIORITY JOURNAL; PROTEIN URINE LEVEL; PROTEINURIA; URINARY EXCRETION;

ADULT; ALBUMINS; BETA 2-MICROGLOBULIN; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; KIDNEY DISEASES; KIDNEY TUBULES; MALE; MIDDLE AGED; PROTEINURIA;

EID: 0033033298     PISSN: 00282766     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Schardijn GH, Statius van Eps LW: Beta-2-microglohulin: Its significance in the evaluation of renal function. Kidney Int 1987;32: 635-641.
2. 2-microglobulin to diagnose tubulo-interstitial renal lesions in children. Kidney Int 1986;30:91-98.
3. Schainuck LI, Striker GE, Cutler RE, Benditt EP: Structural-functional correlations in renal disease. Hum Pathol 1970;1:631-641.
4. 2-microglobulin predicts renal outcome in patients with idiopathic membranous nephropathy. J Am Soc Nephrol 1995; 6:1666-1669.
5. Bazzi C, Petrini C, Rizza V, Arrigo G, Beltrame A, D'Amico G: Characterization of proteinuria in primary glomerulonephritides. SDS-PAGE patterns: Clinical significance and prognostic value of low molecular weight (tubular) proteins. Am J Kidney Dis 1997;29:27-35.
6. Sesso R, Santos AP, Nishida SK, Klag MJ, Carvalhaes JT, Ajzen H, Ramos OL, Pereira AB: Prediction of steroid responsiveness in the idiopathic nephrotic syndrome using urinary retinol-binding protein and beta-2-microglobulin. Ann Intern Med 1992;116:905-909.
7. Bernard A, Ouled Amor A, Viau C, Lauwerys R: The renal uptake of proteins: A nonselective process in conscious rats. Kidney Int 1988;34: 175-185.
8. Sluiter HE, Wetzels JFM, Huysmans FThM, Koene RAP: The natriuretic effect of the dihydropyridine calcium antagonist felodipine: A placebo-controlled study involving intravenous angiotensin II in normotensive volunteers. J Cardiovasc Pharmacol 1987;10(suppl 10): 154-161.
9. Elving LD, Bakkeren JAJM, Jansen MJH, de Kat Angelino CM, de Nobel E, van Munster PJJ: Screening for microalbuminuria in patients with diabetes mellitus: Frozen storage of urine samples decreases their albumin content. Clin Chem 1989;35:308-310.
10. Reichert LJM, Koene RAP, Wetzels JFM: Urinary IgG excretion as a prognostic factor in idiopathic membranous nephropathy. Clin Nephrol 1997;48:79-84.
11. Maack T, Hyung Park C, Camargo M-JF: Renal filtration, transport, and metabolism of proteins; in Seldin DW, Giebisch G (eds): The Kidney: Physiology and Pathophysiology. New York, Raven Press, 1992, pp 3005-3038.
12. Hutchison FN, Kaysen GA: Albuminuria causes lysozymuria in rats with Heymann nephritis. Kidney Int 1988;33:787-791.
13. Shemesh O, Deen WM, Brenner BM, McNeely E, Myers BD: Effect of colloid volume expansion on glomerular barrier size-selectivity in humans. Kidney Int 1986;29:916-923.
14. Beetham R, Newman D: Urinary albumin and low molecular weight protein excretion in the nephrotic syndrome-sequential studies during corticosteroid treatment. Ann Clin Biochem 1992;29:450-453.
15. Harrison JF, Lunt GS, Scott P, Blainey JD: Urinary lysozyme, ribonuclease, and low-molecular-weight protein in renal disease. Lancet 1968;1:371-375.
16. Alt JM, Hacke M, von der Heyde D, Janig H, Junge P-M, Olbricht Ch, Schurek H-J, Stolte H: Urinary protein excretion in interstitial and tubular kidney disease as characterized by gradient electrophoresis. Klin Wochenschr 1983; 61:641-648.
17. Simonnet H, Gauthier C, Vincent C, Revillard J-P: The binding of beta-2-microglobulin to renal brush-border membrane: Affinity measurement, inhibition by serum albumin. Biochim Biophys Acta 1988;940:247-254.
18. Bernard A, Viau C, Ouled A, Lauwerys R: Competition between low-and high-molecular-weight proteins for renal tubular uptake. Nephron 1987;45:115-118.