Mechanism of the uricosuric action of the anti-inflammatory drug E3040 used to treat inflammatory bowel disease. I: Study using a rat model of hyperuricemia

Biopharmaceutics and Drug Disposition

Volumn 20, Issue 2, 1999, Pages 77-83

  Yamada, Harumi ^a,d   Kotaki, Hajime ^a   Furitsu, Hisao ^b   Sawada, Yasufumi ^c   Tatsuji, Iga ^a  

^a UNIVERSITY OF TOKYO HOSPITAL   (Japan)

^b EISAI CO LTD   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d THE UNIVERSITY OF TOKYO   (Japan)

Author keywords

Clearance study; E3040; Hyperuricemic rat; Renal proximal tubules; Uricosuric effect

Indexed keywords

6 HYDROXY 5,7 DIMETHYL 2 METHYLAMINO 4 (3 PYRIDYLMETHYL)BENZOTHIAZOLE; ANTIINFLAMMATORY AGENT; URIC ACID; URICOSURIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENTERITIS; HYPERURICEMIA; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE; MALE; NONHUMAN; RAT; TISSUE DISTRIBUTION; URIC ACID BLOOD LEVEL; URIC ACID URINE LEVEL;

ANIMALS; BENZOTHIAZOLES; DISEASE MODELS, ANIMAL; INFLAMMATORY BOWEL DISEASES; INULIN; KIDNEY TUBULES, PROXIMAL; LIPOXYGENASE INHIBITORS; MALE; PYRIDINES; RATS; RATS, WISTAR; THIAZOLES; THROMBOXANE-A SYNTHASE; URIC ACID; URICOSURIC AGENTS;

EID: 0033032577     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-081X(199903)20:2<77::AID-BDD154>3.0.CO;2-D     Document Type: Article

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