Gastric acid blockade with omeprazole promotes gastric carcinogenesis induced by duodenogastric reflux

Digestive Diseases and Sciences

Volumn 44, Issue 6, 1999, Pages 1132-1135

  Wetscher, Gerold J ^a,b   Hinder, Ronald A ^a   Smyrk, Tom ^a   Perdikis, Galen ^a   Adrian, Thomas E ^a   Profanter, Christoph ^a  

^a CREIGHTON UNIVERSITY   (United States)

^b UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Carcinogenesis; Duodenogastric reflux; Esophagus; Stomach

Indexed keywords

OMEPRAZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DUODENOGASTRIC REFLUX; EPITHELIUM HYPERPLASIA; ESOPHAGUS MUCOSA; EXPERIMENTAL SURGERY; GASTROENTEROSTOMY; HISTOLOGY; MALE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RAT; STOMACH ACID SECRETION; STOMACH ADENOCARCINOMA;

ADENOCARCINOMA; ANIMALS; ANTI-ULCER AGENTS; DISEASE MODELS, ANIMAL; DUODENOGASTRIC REFLUX; ESOPHAGEAL NEOPLASMS; ESOPHAGUS; GASTRIC ACID; HYPERPLASIA; MALE; OMEPRAZOLE; PROTON PUMPS; RATS; RATS, SPRAGUE-DAWLEY; STOMACH; STOMACH NEOPLASMS;

EID: 0033031754     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026615905170     Document Type: Article

References (21)

1. 1. Ritchie WP: Alkaline reflux gastritis: A critical reappraisal. Gut 25:975-987, 1984
2. 2. Kalima TV: Reflux gastritis unrelated to gastric surgery. Scand J Gastroenterol 17(suppl 79):66-71, 1982
3. 3. Gowen GF: Spontaneous enterogastric reflux gastritis and esophagitis. Ann Surg 201:170-175, 1985
4. 4. Stein HJ, Feussner H, Kauer W, DeMeester TR, Siewert JR: Alkaline gastroesophageal reflux: Assessment by ambulatory esophageal aspiration and pH monitoring. Am J Surg 167:163-167, 1994
5. 5. Wetscher GJ, Hinder RA, Kretchmar D, Stinson R, Perdikis G, Smyrk T, Klingler P, Adrian TE: Duodenogastric reflux causes growth stimulation of foregut mucosa potentiated by gastric acid blockade. Dig Dis Sci 41:2166-2173, 1996
6. 6. Taylor PR, Mason RC, Filipe MI, Vaja S, Hanley DC, Murphy GM, Dowling RH, McColl 1: Gastric carcinogenesis in the rat induced by duodenogastric reflux without carcinogens: Morphology, mucin histochemistry, polyamine metabolism, and labelling index. Gut 32:1447-1454, 1991
7. 7. Attwood SEA, Smyrk TC, DeMeester TR, Mirvish SS, Stein HJ, Hinder RA: Duodenoesophageal reflux and the development of esophageal adenocarcinoma in rats. Surgery 111:503-510, 1992
8. 8. Schwab GP, Wetscher GJ, Klingler A, Kreczy A, Öfner C, Berresheim U, Gadenstätter M: Is there a dysplasia-carcinoma sequence in rat gastric remnant? Dig Dis Sci 42:608-615, 1997
9. 9. Langhans P, Heger RA, Hohenstein J, Schlake W, Bünte H: Operation-sequel carcinoma of the stomach. Experimental studies of surgical techniques with or without resection. World J Surg 5:595-605, 1981
10. 10. Pointner R, Wetscher GJ, Gadenstätter M, Bodner E, Hinder RA: Gastric remnant cancer has a better prognosis than primary gastric cancer. Arch Surg 129:615-619, 1994
11. 11. Viste A, Bjornestad E, Opheim P, Skarstein A, Thunold J, Hartveit F, Eide GE, Eide TJ, Soretde O: Risk of carcinoma following gastric operations for benign disease. A historical cohort study of 3470 patients. Lancet 2:502-505, 1986
12. 12. Perdikis G, Wilson P, Hinder RA, Redmond E, Wetscher G, Neary P, Adrian T, Quigley E: Abnormal antroduodenal motility after cholecystectomy. Am J Surg 168:609-615, 1994
13. 13. Stein HJ, Kauer KH, Feussner H, Siewert JR: Bile reflux in benign and malignant Barrett's esophagus and effect of Nissen fundoplication. Gastroenterology 112:A1476, 1997
14. 14. Pera M, Cardesa A, Bombi JA, Heinrich E, Peru C, Mohr U: Influence of esophagojejunostomy on the induction of adenocarcinoma of the distal esophagus in Sprague-Dawley rats by the subcutaneous injection of 2,6-dimethylnitrosomorpholine. Cancer Res 49:6803-6808, 1989
15. 15. Wetscher GJ, Perdikis G, Kretchmar DH, Stinson RG, Bagchi D, Redmond EJ, Adrian TE, Hinder RA: Esophagitis in Sprague-Dawley rats is mediated by free radicals. Dig Dis Sci 40:1297-1305, 1995
16. 16. Wetscher GJ, Hinder PR, Bagchi D, Perdikis G, Redmond EJ, Glaser K, Adrian TE, Hinder RA: Free radical scavengers prevent reflux esophagitis in rats. Dig Dis Sci 40:1292-1296, 1995
17. 17. Wetscher GJ, Hinder RA, Bagchi D, Hinder PR, Bagchi M, Perdikis G, McGinn T: Reflux esophagitis in humans is mediated by oxygen-derived tree radicals. Am J Surg 170:552-557, 1995
18. 18. Klinkenberg-Knol EC, Festen HPM, Jansen JBMJ, Lamers CBHW, Nelis F, Snel P, Lückers A, Dekkers CPM, Havu N, Meuwissen SGM: Long-term treatment with omeprazole for refractory reflux esophagitis: Efficacy and safety. Ann Intern Med 121:161-167, 1994
19. 19. Wetscher GJ, Profanter C, Gadenstätter M, Perdikis G, Glaser K, Hinder RA: Medical treatment of gastroesophageal reflux disease does not prevent the development of Barrett's metaplasia and poor esophageal body motility. Langenbecks Arch Chir 382:95-99, 1997
20. 20. Blot WJ, Devesa SS, Kneller RW, Fraumeni JF: Rising incidence of a denocarcinoma of the esophagus and gastric cardia. JAMA 265:1287-1289, 1991
21. 21. Clark GWB, Smyrk TC, Burdiles P, Hoeft S, Peters JH, Kiyabu M, Hinder RA, Bremner CG, DeMeester TR: Is Barrett's metaplasia the source of adenocarcinomas of the cardia? Arch Surg 129:609-614, 1994