The development of bone changes induced in rats by recombinant human granulocyte colony-stimulating factor is suppressed by bisphosphonate

Histology and Histopathology

Volumn 14, Issue 3, 1999, Pages 679-686

  Suzuki, M ^a,b   Adachi, K ^b   Sugimoto, T ^b   Nakayama, H ^a   Doi, K ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Bisphosphonate; Granulocyte colony stimulating factor; Intramembranous ossification; Osteoclastic bone resorption; Osteogenesis

Indexed keywords

ACID PHOSPHATASE; BISPHOSPHONIC ACID DERIVATIVE; CALCIUM; INOSITOL PHOSPHATE; PAMIDRONIC ACID; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE; BONE DEVELOPMENT; BONE MARROW; DRUG EFFECT; ENZYME ACTIVITY; HEMATOPOIESIS; HISTOPATHOLOGY; LEUKOCYTE COUNT; MALE; NONHUMAN; OSTEOLYSIS; RAT; SPLEEN WEIGHT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; BODY WEIGHT; BONE MARROW; BONE RESORPTION; CALCIUM; DIPHOSPHONATES; FEMUR; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; LEUKOCYTE COUNT; MALE; ORGAN SIZE; OSTEOGENESIS; PHOSPHORUS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SPLEEN; TIBIA;

ANIMALIA;

EID: 0033031686     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (2)

1. Barka T. and Anderson P.J. (1962). Histochemical methods for acid phosphatase using hexazonium pararosaniline as coupler. J. Histochem. Cytochem. 10, 741-753.
2. Boonekamp P.M., van der Wee-Pals L.J., van Wijk-van Lennep M.M., Thesing C.W. and Bijvoet O.L. (1986). Two modes of action of bisphosphonates on osteoclastic resorption of mineralized matrix. Bone Miner. 1, 27-39.