Metabolism blocked classical folate analog inhibitors of dihydrofolate reductase-1: Synthesis and biological evaluation of Mobiletrex

Medicinal Chemistry Research

Volumn 9, Issue 3, 1999, Pages 176-185

  Nair, M Gopal ^a   Fayard, Melanie L ^a   Lariccia, Joanna M ^a   Amato, Alaina E ^a   McGuire, John J ^b   Galivan, John H ^c   Kisliuk, Roy L ^d  

^a UNIVERSITY OF SOUTH ALABAMA   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

^c WADSWORTH CENTER   (United States)

^d TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4' METHYLENE 5,8,10 TRIDEAZAAMINOPTERIN; AMINOPTERIN DERIVATIVE; ANTINEOPLASTIC AGENT; DIHYDROFOLATE REDUCTASE INHIBITOR; FOLIC ACID DERIVATIVE; METHOTREXATE; MOBILETREX; PTEROPTIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CATABOLISM; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROLYSIS; HYDROXYLATION; ION EXCHANGE CHROMATOGRAPHY; METABOLIC INHIBITION; REACTION ANALYSIS; REVERSED PHASE LIQUID CHROMATOGRAPHY; SYNTHESIS;

EID: 0033031215     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Baugh, C.M.; Krumdieck, C.L.; Nair, M.G. Biochem. Biophys. Res. Comm. 1973, 52, 27-35
2. Nair, M.G.; Baugh, C.M. Biochemistry. 1973, 12, 3923-28
3. Kisliuk, R.L.; Gaumont, Y.; Nair, M.G. Proc. 2nd workshop on folyl and antifolylpolyglutamates. Goldman, I.D. (Ed). Praeger Scientific. 1985, 319-328.
4. Kumar, P.; Kisliuk, R.L.; Gaumont, Y.; Freisheim, J.H.; Nair, M.G. Biochem. Pharmacol 1989, 38, 543-546.
5. Jolivet, J.; Schilsky, R.L.; Bailey, B.D.; Drake, J.C.; Chabner, B.A. 1982, 70, 351-360.
6. Chabner, B.A.; Allegra, C.J.; Cuot, G. A. et al. J. Clin. Invest. 1985, 260, 9720-26.
7. Jacobs, S. A.; Stoller, R.G.; Chabner, B.A.; Johns, D. G. J. Clin. Invest. 1976, 57, 534-538.
8. Donehower, R.C.; Hande, K.R.; Drake, J.C. Clin Pharmacol. Ther. 1979, 26, 63-72.
9. Abraham, A.; Pati, R.; Galivan, J.H.; Rhee, M.S.; McGuire, J.J.; Kisliuk, R.L.; Hausheer, F.H.; Nair, M.G. Cellular Pharmacology. 1996, 3, 29-34.
10. Smeland, E.; Bremmes, R.; Eide, R.J.; Huseby, N.E.; Aarbakke, J. Proc. Amer. Assoc. Cancer. Research. 1994, 35, 302, 1978.
11. McGuire, J.J.; Bergoltz, V.V.; Heitzman, K.J.; Haile, W.H.; Russel, C.A.; Bolanoswka, W.E.; Kotake, Y.; Haneda, T.; Nomura, H. Cancer Research. 1994, 54, 2673-2679.
12. Abraham, A.; McGuire, J.J.; Galivan, J.; Nimec, Z.; Kisliuk, R.L.; Gaumont, Y.; Nair, M.G. J. Med. Chem. 1991, 34, 222-227.
13. Boyd, M.R.; Paull, K.S. Drug. Development. Res. 1995, 34, 91-109.
14. Rhee, M.S.; Wang, Y.; Nair, M.G., Galivan, J. Cancer. research. 1993, 53, 2227-2230.
15. Johns, D.G.; Loo, T.L. J. Pharm. Science. 1967, 56, 256-262.