Enhanced production of D-β-hydroxyisobutyric acid through strain improvement

Journal of Biotechnology

Volumn 69, Issue 1, 1999, Pages 75-79

  Kim, Chul Ho ^a   Hong, Won Kyoung ^a   Lee, In Young ^a   Choi, Eui Sung ^a   Rhee, Sang Ki ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

Candida rugosa; D Hydroxyisobutyric acid; Isobutyric acid

Indexed keywords

BATCH CELL CULTURE; YEAST;

ENANTIOSELECTIVITY; HYDROXYISOBUTYRIC ACID;

CARBOXYLIC ACIDS;

BETA HYDROXYISOBUTYRIC ACID; CARBOXYLIC ACID DERIVATIVE; ISOBUTYRIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CANDIDA RUGOSA; CULTURE MEDIUM; FERMENTATION; FUNGUS MUTANT; NONHUMAN; PRIORITY JOURNAL; PRODUCTIVITY; STRAIN DIFFERENCE;

CANDIDA RUGOSA;

EID: 0033030574     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1656(99)00003-6     Document Type: Article

References (5)

1. Hasegawa J., Ogura M., Hamaguchi S., Shimazaki M., Kawaharada H., Watanabe K. Stereospecific conversion of isobutyric acid to D-β-hydroxyisobutyric acid by microorganism. J. Ferment. Technol. 59:1981;203-208.
2. Hasegawa J., Ogura M., Kanema H., Noda N., Kawaharada H., Watanabe K. Production of D-β-hydroxyisobutyric acid by Candida rugosa and its mutant. J. Ferment. Technol. 60:1982;501-508.
3. Lee I.Y., Hong W.K., Hwang Y.B., Kim C.H., Choi E.S., Rhee S.K., Park Y.H. Production of D-β-hydroxyisobutyric acid from isobutyric acid by Candida rugosa. J. Ferment. Bioeng. 81:1996;255-258.
4. Lee I.Y., Kim C.H., Yeon B.K., Hong W.K., Choi E.S., Rhee S.K., Park Y.H., Sung D.H., Baek W.H. High production of D-β-hydroxyisobutyric acid from methacrylic acid by Candida rugosa and its mutant. Bioprocess Eng. 16:1997;247-252.
5. Sprecher M., Sprinson D.B. Preparation of (R)-(-)-β-hydroxyisobutyric acid from threo-3-methyl-L-asparate. J. Biol. Chem. 241:1966;868-871.