Diabetic gastropathy: Gastric neuromuscular dysfunction in diabetes mellitus: A review of symptoms, pathophysiology, and treatment

Digestive Diseases and Sciences

Volumn 44, Issue 6, 1999, Pages 1061-1075

  Koch, Kenneth L ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

Diabetes mellitus; Gastric dysrhythmias; Gastrokinetic agents; Gastroparesis; Gastropathy; Nausea and vomiting

Indexed keywords

ANTIDEPRESSANT AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CISAPRIDE; DOMPERIDONE; ERYTHROMYCIN; GANGLION BLOCKING AGENT; LEVODOPA; METOCLOPRAMIDE; NICOTINE; OCTREOTIDE; OPIATE; TRANQUILIZER; VINCRISTINE;

DIABETES MELLITUS; DIET THERAPY; DIFFERENTIAL DIAGNOSIS; ECHOGRAPHY; ELECTROGASTROGRAPHY; GASTROINTESTINAL SYMPTOM; HUMAN; MUSCLE TONE; MYOELECTRICITY; NEUROMUSCULAR DISEASE; PRIORITY JOURNAL; REVIEW; SIDE EFFECT; STOMACH DISEASE; STOMACH EMPTYING; STOMACH MOTILITY; STOMACH MUSCLE; STOMACH PARESIS; STOMACH SCINTISCANNING;

DIABETES COMPLICATIONS; DIABETES MELLITUS; DIABETIC DIET; DIAGNOSIS, DIFFERENTIAL; GASTROINTESTINAL AGENTS; GASTROINTESTINAL MOTILITY; HUMANS; HYPOGLYCEMIC AGENTS; NEUROMUSCULAR DISEASES; STOMACH; STOMACH DISEASES;

EID: 0033030001     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026647417465     Document Type: Review

References (66)

1. 1. Feldman M, Schiller LR: Disorders of gastrointestinal motility associated with diabetes mellitus. Ann Intern Med 98:378-384, 1983
2. 2. Undeland KA, Hausken T, Svebak S, Aanderud S, Berstad A: Wide gastric antrum and low vagal tone in patients with diabetes mellitus type I compared to patients with functional dyspepsia and healthy individuals. Dig Dis Sci 41:9-16, 1996
3. 3. Wooten RL, Meriwether TW: Diabetic gastric atony: A clinical study. JAMA 176:68-73, 1961
4. 4. Horowitz M, Edelbroek M, Fraser R, Maddox A, Wishart J: Disordered gastric motor function in diabetes mellitus. Recent insights into prevalence, pathophysiology, clinical relevance, and treatment. Scand J Gastroenterol 26:673-684, 1991
5. 5. Koch KL, Stern RM, Stewart WR, Vasey MW: Gastric emptying and gastric myoelectrical activity in patients with diabetic gastroparesis: Effect of long-term domperidone treatment. Am J Gastroenterol 84:1069-1075, 1989
6. 6. Abell TL, Camilleri M, Hench VS, Malagelada J-R: Gastric electromechanical function and gastric emptying in diabetic gastroparesis. Eur J Gastroenterol Hepatol 3:163-167, 1991
7. 7. Rothstein RD, Alavi A, Reynolds JC: Electrogastrography in patients with gastroparesis and effect of long-term cisapride. Dig Dis Sci 38:1518-1524, 1993
8. 8. Malagelada J-R, Rees WDW, Mazzotta LJ, Go VLW: Gastric motor abnormalities in diabetic and postvagotomy gastroparesis: Effect of metoclopramide and bethanechol. Gastroenterology 78:286-293, 1980
9. 9. Lin HC, Hasler WL: Disorders of gastric emptying. In Textbook of Gastroenterology, 2nd ed. T Yamada (ed). Philadelphia, JB Lippincott, 1995, pp 1318-1346
10. 10. Clouse RE, Lustman PJ: Gastrointestinal symptoms in diabetic patients: Lack of association with neuropathy. Am J Gastroenterol 84:868-872, 1989
11. 11. Koch KL: Approach to the patient with nausea and vomiting. In Textbook of Gastroenterology, 2nd ed. T Yamada (ed). Philadelphia, JB Lippincott, 1995, pp 731-749
12. 12. Koch KL: Stomach. In Atlas of Gastrointestinal Motility in Health and Disease. MM Schuster (ed). Baltimore, Williams and Wilkins, 1993, pp 158-176
13. 13. Malagelada J-R, Azpiroz F, Mearin F: Gastroduodenal motor function in health and disease. In Gastrointestinal Disease: Pathophysiology/Diagnosis/Management, Vol 1. MH Sleisenger, JS Fordtran (eds). Philadelphia, WB Saunders, 1993, pp 486-508
14. 14. Goyal RK, Hirano I: The enteric nervous system. N Engl J Med 334:1106-1115, 1996
15. 15. Thuneberg L: Interstitial cells of Cajal. In Handbook of Physiology, The Gastrointestinal System, Sect 6, Vol 1, Part 1. JD Wood (ed). Bethesda, American Physiological Society, 1989, pp 349-386
16. 16. Hinder RA, Kelly KA: Human gastric pacesetter potential. Site of origin, spread, and response to gastric transection and proximal gastric vagotomy. Am J Surg 133:29-33, 1978
17. 17. Koch KL, Stern RM: Functional disorders of the stomach. Semin Gastrointest Dis 7:185-195, 1996
18. 18. Koch KL, Stewart WR, Stern RM: Effect of barium meals on gastric electromechanical activity in man. A fluoroscopic-electrogastrographic study. Dig Dis Sci 32:1217-1222, 1987
19. 19. Kassander P: Asymptomatic gastric retention in diabetics (gastroparesis diabeticorum). Ann Intern Med 48:797-812, 1958
20. 20. Horowitz M, Harding PE, Maddox AF, Wishart JM, Akkermans LMA, Chatterton BE, Shearman DJC: Gastric and oesophageal emptying in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 32:151-159, 1989
21. 21. Zitomer BR, Gramm HF, Kozak GP: Gastric neuropathy in diabetes mellitus: Clinical and radiographic observations. Metabolism 17:199-211, 1968
22. 22. Hodges DS: Extrinsic nerve dysfunction causing gastrointestinal dysmotility. In Motility Disorders of the Gastrointestinal Tract: Principles and Practice. S Anuras (ed). New York, Raven Press, 1992, pp 255-297
23. 23. Yoshida MM, Schuffler MD, Sumi SM: There are no morphologic abnormalities of the gastric wall or abdominal vagus in patients with diabetic gastroparesis. Gastroenterology 94:907-914, 1988
24. 24. Koch KL, Stern RM: Electrogastrography. In An Illustrated Guide to Gastrointestinal Motility, 2nd ed. D Kumar, D Wingate (eds). London, Churchhill Livingstone, 1993, pp 290-307
25. 25. Stern RM, Koch KL, Stewart WR, Vasey MW: Electrogastrography: Current issues in validation and methodology. Psychophysiology 24:55-64, 1987
26. 26. Jebbink HJA, Bruijs PPM, Bravenboer B, Akkermans LMA, vanBerge-Henegouwen GP, Smout AJPM: Gastric myoelectrical activity in patients with Type I diabetes mellitus and autonomic neuropathy. Dig Dis Sci 39:2376-2383, 1994
27. 27. Cucchiara S, Minella R, Riezzo G, Vallone G, Vallone P, Castellone F, Auricchio S: Reversal of gastric electrical dysrhythmias by cisapride in children with functional dyspepsia. Report of three cases. Dig Dis Sci 37:1136-1140, 1992
28. 28. Hausken T, Berstad A: Wide gastric antrum in patients with non-ulcer dyspepsia. Effect of cisapride. Scand J Gastroenterol 27:427-432, 1992
29. 29. Mearin F, Camilleri M, Malagelada J-R: Pyloric dysfunction in diabetics with recurrent nausea and vomiting. Gastroenterology 90:1919-1925, 1986
30. 30. Undeland KA, Hausken T, Aanderud S, Berstad A: Lower postprandial gastric volume response in diabetic patients with vagal neuropathy. Neurogastroenterol Motil 9:19-24, 1997
31. 31. Koch KL, Stern RM, Vasey MW, Seaton JF, Demers LM, Harrison TS: Neuroendocrine and gastric myoelectrical responses to illusory self-motion in humans. Am J Physiol 258:E304-E310, 1990
32. 32. Stoddard CJ, Smallwood RH, Duthie HL: Electrical arrhythmias in the human stomach. Gut 22:705-712, 1981
33. 33. Hasler WL, Soudah HC, Dulai G, Owyang C: Mediation of hyperglycemia-evoked gastric slow-wave dysrhythmias by endogenous prostaglandins. Gastroenterology 108:727-736, 1995
34. 34. Fraser R, Horowitz M, Dent J: Hyperglycaemia stimulates pyloric motility in normal subjects. Gut 32:475-478, 1991
35. 35. Fraser RJ, Horowitz M, Maddox AF, Harding PE, Chatterton BE, Dent J: Hyperglycaemia slows gastric emptying in Type I (insulin-dependent) diabetes mellitus. Diabetologia 33:675-680, 1990
36. 36. Schvarcz E, Palmér M, Åman J, Horowitz M, Stridsberg M, Berne C: Physiological hyperglycemia slows gastric emptying in normal subjects and patients with insulin-dependent diabetes mellitus. Gastroenterology 113:60-66, 1997
37. 37. Keshavarzian A, Iber FL, Vaeth J: Gastric emptying in patients with insulin-requiring diabetes mellitus. Am J Gastroenterol 82:29-35, 1987
38. 38. Keshavarzian A, Iber FL: Gastrointestinal involvement in insulin-requiring diabetes mellitus. J Clin Gastroenterol 9:685-692, 1987
39. 39. Parkman HP, Fisher RS: Gastroparesis. In Consultations in Gastroenterology. WJ Snape, Jr (ed). Philadelphia, WB Saunders, 1996, pp 269-279
40. 40. Zarich S, Waxman S, Freeman RT, Mittleman M, Hegarty P, Nesto RW: Effect of autonomic nervous system dysfunction on the circadian pattern of myocardial ischemia in diabetes mellitus. JACC 24:956-962, 1994
41. 41. Nilsson P-H: Diabetic gastroparesis: A review. J Diab Comp 10:113-122, 1996
42. 42. Weber FH, McCallum RW: Gastric motor disorders. In Consultations in Gastroenterology. WJ Snape, Jr (ed). Philadelphia, WB Saunders, 1996, pp 247-259
43. 43. Barbara L, Camilleri M, Corinaldesi R, Crean GP, Heading RC, Johnson AG, Malagelada J-R, Stanghellini V, Wienbeck M: Definition and investigation of dyspepsia. Consensus of an international ad hoc working party. Dig Dis Sci 34:1272-1276, 1989
44. 44. Rydall AC, Rodin GM, Olmsted MP, Devenyi RG, Daneman D: Disordered eating behavior and microvascular complications in young women with insulin-dependent diabetes mellitus. N Engl J Med 336:1849-1854, 1997
45. 45. Parkman HP, Harris AD, Krevsky B, Urbain J-LC, Maurer AH, Fisher RS: Gastroduodenal motility and dysmotility: An update on techniques available for evaluation. Am J Gastroenterol 90:869-892, 1995
46. 46. Ghoos YF, Maes BD, Geypens BJ, Mys G, Hiele MI, Rutgeerts PJ, Vantrappen G: Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. Gastroenterology 104:1640-1647, 1993
47. 47. Berstad A, Hausken T, Gilja OH, Hveem K, Nesje LB, Ødegaard S: Ultrasonography of the human stomach. Scand J Gastroenterol 31(suppl 220):75-82, 1996
48. 48. Schwizer W, Fraser R, Borovicka J, Asal K, Crelier G, Kunz P, Boesiger P, Fried M: Measurement of proximal and distal gastric motility with magnetic resonance imaging. Am J Physiol 271;G217-G222, 1996
49. 49. Quigley EMM: Intestinal manometry-Technical advances, clinical limitations. Dig Dis Sci 37:10-13, 1992
50. 50. Koch KL: Dyspepsia of unknown origin: Pathophysiology, diagnosis, and treatment. Dig Dis 15:316-329, 1997
51. 51. Albibi R, McCallum RW: Metoclopramide: Pharmacology and clinical application. Ann Intern Med 98:86-95, 1983
52. 52. Brogden RN, Carmine AA, Heel RC, Speight TM, Avery GS: Domperidone: A review of its pharmacological activity, pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an antiemetic. Drugs 24:360-400, 1982
53. 53. Horowitz M, Harding PE, Chatterton BE, Collins PJ, Shearman DJC: Acute and chronic effects of domperidone on gastric emptying in diabetic autonomic neuropathy. Dig Dis Sci 30:1-9, 1985
54. 54. Silvers D, Kipnes M, Broadstone V, Patterson D, Quigley EMM, McCallum R, Joslyn A: Domperidone significantly improves gastrointestinal symptoms associated with diabetic gastroparesis. Gastroenterology 112(suppl):A826, 1997
55. 55. Patterson D, Abell T, Rothstein RD, Koch K, Barnett J, Long J: A double-blind multicenter comparison of domperidone and metoclopramide in the treatment of diabetic gastroparesis. Gastroenterology 106:A554, 1994
56. 56. Soykan I, Sarosiek I, McCallum RW: The effect of chronic oral domperidone therapy on gastrointestinal symptoms, gastric emptying, and quality of life in patients with gastroparesis. Am J Gastroenterol 92:976-980, 1997
57. 57. Wiseman LR, Faulds D: Cisapride. An updated review of its pharmacology and therapeutic efficacy as a prokinetic agent in gastrointestinal motility disorders. Drugs 47:116-152, 1994
58. 58. Horowitz M, Maddox A, Harding PE, Maddern GJ, Chatterhorn BE, Wishart J, Shearman DJC: Effect of cisapride on gastric and esophageal emptying in insulin-dependent diabetes mellitus. Gastroenterology 92:1899-1907, 1987
59. 59. Camilleri M, Malagelada J-R, Abell TL, Brown ML, Hench V, Zinsmeister AR: Effect of six weeks of treatment with cisapride in gastroparesis and intestinal pseudoobstruction. Gastroenterology 96:704-712, 1989
60. 60. Janssens J, Peeters TL, Vantrappen G, Tack J, Urbain JL, De Roo M, Muls E, Bouillon R: Improvement of gastric emptying in diabetic gastroparesis by erythromycin. Preliminary studies. N Engl J Med 322:1028-1031, 1990
61. 61. Richards RD, Davenport K, McCallum RW: The treatment of idiopathic and diabetic gastroparesis with acute intravenous and chronic oral erythromycin. Am J Gastroenterol 88:203-207, 1993
62. 62. Koch KL, Bingaman S, Xu L, Stern RM, Muth E: Acute effects of acustimulation at Neiguan point on nausea and gastric myoelectrical activity in patients with chronic nausea. Gastroenterology 112(suppl):A763, 1997
63. 63. GEMS Study Group: Report of a multicenter study on electrical stimulation for the treatment of gastroparesis. Gastroenterology 112(suppl):A735, 1997
64. 64. Evans AT, Samuels SN, Marshall C, Bertolucci LE: Suppression of pregnancy-induced nausea and vomiting with sensory afferent stimulation. J Reprod Med 8:603-606, 1993
65. 65. Dundee JW, Ghaly RG, Bill KM, Chestnutt WN, Fitzpatrick KTJ, Lynas AGA: Effect of stimulation of the P6 antiemetic point on postoperative nausea and vomiting. Br J Anaesth 63:612-618, 1989
66. 66. Dundee JW, Yang J, McMillan C: Non-invasive stimulation of the P6 (Neiguan) antiemetic acupuncture point in cancer chemotherapy. J R Soc Med 84:210-212, 1991