St. John's wort: A new alternative for depression?

International Journal of Clinical Pharmacology and Therapeutics

Volumn 37, Issue 3, 1999, Pages 111-119

  Josey, E S ^a   Tackett, R L ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Antidepressant; Hypericum perforatum; Monoamine oxidase inhibitor; Serotonin selective reuptake inhibitor; St. John's wort; Tricyclic antidepressant

Indexed keywords

ADRENERGIC RECEPTOR STIMULATING AGENT; AMITRIPTYLINE; ANTIDEPRESSANT AGENT; BARBITURIC ACID DERIVATIVE; CHOLINERGIC RECEPTOR BLOCKING AGENT; FLUOXETINE; IMIPRAMINE; INTERLEUKIN 6; METHYLPHENIDATE; MONOAMINE OXIDASE INHIBITOR; NON PRESCRIPTION DRUG; PAROXETINE; PETHIDINE; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; STEROID; TRICYCLIC ANTIDEPRESSANT AGENT;

AFFECTIVE NEUROSIS; ARTICLE; CLINICAL TRIAL; CONSTIPATION; DATA BASE; DEPRESSION; DRUG EFFICACY; DRUG FATALITY; DRUG HYPERSENSITIVITY; DRUG SAFETY; DRUG USE; FATIGUE; GASTROINTESTINAL DISEASE; HALLUCINATION; HEADACHE; HUMAN; HYPERICUM PERFORATUM; HYPERPYREXIA; INSOMNIA; NAUSEA; ORTHOSTATIC HYPOTENSION; PHOTOSENSITIVITY DISORDER; SYMPTOM; TACHYCARDIA; VISUAL IMPAIRMENT; XEROSTOMIA;

EID: 0033029551     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Baldessarini RJ 1990 Drugs and the treatment of psychiatric disorders. In: Gilman AG, Rall TW, Nies AS, Taylor P (eds) Goodman and Gilman's The Pharmacological Basis of Therapeutics. Elmsford, New York, pp 383-435
2. Bech P 1993 Acute therapy of depression. J Clin Psychiatry 54 (Suppl 8): 18-27
3. Bombardelli E, Morazzoni P 1995 Hypericum perforatum. Fitoterapia 66: 43-68
4. Campbell MH, Milne BR, Dellow JJ, Nicol HI 1991 Effect of herbicides on St. John's wort (Hypericum perforatum L.). Aus J Exp Agr 31: 499-501
5. Chanerjee SS, Nolder M, Koch E. Erdelmeier C 1998 Antidepressant activity of Hypericum perforatum and hyperforin: the neglected possibility. Pharmacopsychiatry 31 (Suppl): 7-15
6. Cookson J 1993 Side-effects of antidepressants. Br J Psychiatry 163 (Suppl 20): 20-24
7. Crompton CW, Hall IV, Jensen KIN, Hildebrand PD 1988 The biology of Canadian weeds. 83. Hypericum perforatum L. Can J Plant Sci 68: 149-162
8. DeSmet PA, Nolen WA 1996 St. John's wort as an antidepressant. BMJ 313: 241-242
9. Finkel SI 1996 Efficacy and tolerability of antidepressant therapy in the old-old. J Clin Psychiatry 57 (Suppl 5): 23-28
10. Hansgen KD, Vesper J, Ploch M 1994 Multicenter double-blind study examining the antidepressant effectiveness of the Hypericum extract LI 160. J Geriatr Psychiatry Neurol 7 (Suppl 1): 15-18
11. Harrer G, Hubner WD. Podzuweit H 1994 Effectiveness and tolerance of the hypericum extract LI 160 compared to maprotiline: a multicenter double-blind study. J Geriatr Psychiatry Neurol 7 (Suppl 1): 24-28
12. Holzl J, Demisch L, Gollnik B 1989 Investigations about antidepressive and mood-changing effects of Hypericum perforatum. Planta Med 55: 643
13. Kako M, Al-Sultan I, Saleem A 1993 Studies of sheep experimentally poisoned with Hypericum perforatum. Vet Hum Toxicol 35: 298-300
14. Koenig HG, Cohen HJ, Blazer DG, Krishnan KRR, Sibert TE 1993 Profile of depressive symptoms in younger and older medical inpatients with major depression. J Am Geriatr Soc 41: 1169-1176
15. Lader MH 1996 Tolerability and safety: essentials in antidepressant pharmacotherapy. J Clin Psychiatry 57 (Suppl 2): 39-44
16. Linde K, Ramirez G, Mulrow CD, Pauls A, Weidenhammer W, Melchart D 1996 St. John's wort for depression - an overview and meta-analysis of randomised clinical trials. BMJ 313: 253-258
17. Martinez B, Kasper S, Ruhrmann S. Moller HJ 1994 Hypericum in the treatment of seasonal affective disorders. J Geriatr Psychiatry Neurol 7 (Suppl 1): 29-33
18. Melzer R, Fricke U, Holzl J 1991 Vasoactive properties of procyanidins from hypericum perforatum L. in isolated porcine coronary arteries. Arzneimittelforschung/Drug Res 41: 481-483
19. Melzer R, Fricke U, Podehl R, Zylka J 1989 Procyanidins from hypericum perforatum: effects on isolated guinea pig hearts. Planta Med 55: 655-656
20. Muller WE, Singer A, Wonnemann M, Hafner U, Rolli M, Schafer C 1998 Hyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extract. Pharmacopsychiatry 31 (Suppl): 16-21
21. Murray MT 1996 Natural Alternatives to Prozac. New York
22. Newhouse PA 1996 Use of serotonin selective reuptake inhibitors in geriatric depression. J Clin Psychiatry 57 (Suppl 5): 12-22
23. Perovic S, Muller WEG 1995 Pharmacological profile of hypericum extract - effect on serotonin uptake by postsynaptic receptors. Arzneimittelforschung 45: 1145-1148
24. Pittman AM 1992 Patient care in internal medicine. In: Woodley M, Whelan A (eds) Manual of Medical Therapeutics. Boston, Massachusetts, pp 1-24
25. Preskorn SH 1995 Comparison of the tolerability of bupropion fluoxetine imipramine nefazodone paroxetine sertraline and venlafaxine. J Clin Psychiatry 56 (Suppl 6): 12-21
26. Reuter HD 1996 Chemistry and biology of hypericum (St. John's wort). 12th Annual Chemical Society 212: 93
27. Sahelian R 1997 St. John's wort: nature's feel-good herb. Green Bay, Wisconsin
28. Sommer H, Harrer G 1994 Placebo-controlled doubleblind study examining the effectiveness of an hypericum preparation in 105 mildly depressed patients. J Geriatr Psychiatry Neurol 7 (Suppl 1): 9-11
29. Staffeldt B, Kerb R, Brockmoller J, Ploch M, Roots I 1994 Pharmacokinetics of hypericin and pseudohypericin after oral intake of the hypericum perforatum extract LI 160 in healthy volunteers. J Geriatr Psychiatry Neurol 7 (Suppl 1): 47-53
30. Vorbach EU, Hubner WD, Arnoldt KH 1994 Effectiveness and tolerance of the Hypericum extract LI 160 in comparison with imipramine: randomized doubleblind study in 135 outpatients. J Geriatr Psychiatry Neurol 7 (Suppl 1): 19-23
31. Whalley LJ, Bradnock J 1990 Treatment of the classical manifestations of dementia and confusion. Br Med Bull 46: 169-180