Effects of mebudipine and dibudipine, two new calcium-channel blockers, on rat left atrium, rat blood pressure and human internal mammary artery

Journal of Pharmacy and Pharmacology

Volumn 51, Issue 5, 1999, Pages 617-622

  Mirkhani, H ^a   Omrani, G R ^a   Ghiaee, S ^a   Mahmoudian, M ^a  

^a IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; DIBUDIPINE; MEBUDIPINE; NIFEDIPINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY DILATATION; BLOOD PRESSURE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG ABSORPTION; DRUG HALF LIFE; DRUG POTENCY; HEART LEFT ATRIUM; HEART MUSCLE CONTRACTILE FORCE; HUMAN; HUMAN TISSUE; HYPOTENSION; INOTROPISM; INTERNAL MAMMARY ARTERY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

ANIMALS; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; HEART ATRIA; HUMANS; MALE; MAMMARY ARTERIES; NIFEDIPINE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0033029108     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357991772727     Document Type: Conference Paper

References (16)

1. Borchard, U. (1994) Calcium antagonists in comparison: view of the pharmacologist. J. Cardiovasc. Pharmacol. 24 (Suppl. 2): S85-S91
2. Ehring, T., Böhm, M., Heusch, G. (1992) The calcium antagonist nisoldipine improves functional recovery of reperfused myocardium only when given before ischemia. J. Cardiovasc. Pharmacol. 20: 63-74
3. Elkayam, U., Weber, L., McKay, C., Rahimtoola, S. (1985) Spectrum of acute hemodynamic effects of nifedipine in severe congestive heart failure. Am. J. Cardiol. 56: 560-566
4. Ferrari, R., Cucchini, F., Bolognesi, R., Bachetti, T., Boraso, A., Bernocchi, P., Gaia, G., Visioli, O. (1994) How do calcium antagonists differ in clinical practice? Cardiovasc. Drugs Ther. 8: 565-575
5. Furburg, C. D., Psaty B. M., Meyer J. V. (1995) Nifedipine dose-related increase in mortality in patients with coronary heart disease. Circulation 92: 1326-1331
6. Godfraind, T. (1994) Calcium antagonists and vasodilatation. Pharmacol. Ther. 64: 37-75
7. He, G. W., Rosenfeldt, F. L., Buxton, B. F., Angus, J. A. (1989) Reactivity of human isolated internal mammary artery to constrictor and dilator agents. Implications for treatment of internal mammary artery spasm. Circulation 80 (Suppl. I): I141-I150
8. Heusch, G. (1992) Myocardial stunning: a role for calcium antagonists during ischemia? Cardiovasc. Res. 26: 14-19
9. Kloner, R. A. (1995) Nifedipine in ischemic heart disease. Circulation 92: 1074-1078
10. Mahmoudian, M., Mirkhani, H., Nehardani, Z., Ghiaee, S. (1997) Synthesis and biological activity of two new calcium-channel blockers, mebudipine and dibudipine. J. Pharm. Pharmacol. 49: 1229-1233
11. Mirfazaelian, A., Mahmoudian, M. (1995) A comprehensive computer programme for evaluation and teaching drug pharmacokinetics. Abstract Book of the 12th Iranian Congress of Physiology and Pharmacology, p. 336
12. Opie, L. H., Messerli, F. H. (1995) Nifedipine and mortality. Grave defects in dossier. Circulation 92: 1068-1073
13. Parmley, W. W. (1996) Calcium antagonists in the prevention of atherosclerosis. In: Messerli, F. H. (ed.) Cardiovascular Drug Therapy. 2nd edn, W. B. Saunders Co., pp 901-907
14. Pieper, J. A. (1996) Evolving role of calcium channel blockers in heart failure. Pharmacotherapy 16 (Pt.2): 43S-49S
15. Salvetti, A., Di Venanzio, L. (1994) Clinical pharmacology of long-acting calcium antagonists: what relevance for therapeutic effects? J. Cardiovasc. Pharmacol. 23 (Suppl. 5): S31-S34
16. Weiner, D. A. (1988) Calcium-channel blockers. Med. Clin. N. Am. 72: 83-115