Structural and hydration changes in the active site gorge of phosporhylated butyrylcholinesterase accompanying the aging process

Chemico-Biological Interactions

Volumn 119-120, Issue , 1999, Pages 17-27

  Masson, Patrick ^a   Fortier, Pierre Louis ^b   Albaret, Christine ^b   Cléry, Cécile ^a   Guerra, Patrice ^a   Lockridge, Oksana ^c  

^a CENTRE DE RECHERCHES   (France)

^b CENTRE D ETUDES DU BOUCHET   (France)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Aging; Butyrylcholinesterase; Hydrostatic pressure; Molecular dynamics; Organophosphate inhibition; Osmotic pressure

Indexed keywords

CHOLINESTERASE; DYFLOS; MUTANT PROTEIN; SOMAN;

AGING; CONFERENCE PAPER; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME DENATURATION; ENZYME STRUCTURE; HUMAN; HYDRATION; HYDROSTATIC PRESSURE; MOLECULAR DYNAMICS; OSMOTIC PRESSURE; PH; TEMPERATURE;

AGING; BINDING SITES; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; ENZYME STABILITY; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROSTATIC PRESSURE; ISOFLUROPHATE; KINETICS; OSMOTIC PRESSURE; PHOSPHORYLATION; PROTEIN DENATURATION; SOMAN; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 0033029009     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(99)00010-1     Document Type: Conference Paper

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