Outbreak of extended spectrum β lactamase producing Klebsiella pneumoniae in a neonatal unit

Archives of Disease in Childhood: Fetal and Neonatal Edition

Volumn 80, Issue 1, 1999, Pages

  Royle, Jennifer ^a   Halasz, Sharon ^c   Eagles, Gillian ^c   Gilbert, Gwendolyn ^c   Dalton, Dianne ^a   Jelfs, Peter ^b   Isaacs, David ^a  

^a CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^b WESTMEAD HOSPITAL   (Australia)

^c NONE

Author keywords

Antibiotic resistance; Hygiene; Sepsis; lactamase producing Klebsiella pneumoniae

Indexed keywords

AMIKACIN; AMOXICILLIN; AMPICILLIN; ANTIBIOTIC AGENT; BETA LACTAMASE; CEFOTAXIME; CLINDAMYCIN; FLUCLOXACILLIN; GENTAMICIN; IMIPENEM; METRONIDAZOLE; VANCOMYCIN;

ARTICLE; BACTERIAL COLONIZATION; BACTERIUM ISOLATE; CLINICAL ARTICLE; CROSS INFECTION; EPIDEMIC; FEMALE; GRAM NEGATIVE INFECTION; HAND WASHING; HOSPITAL INFECTION; HUMAN; HYGIENE; INFECTION CONTROL; KLEBSIELLA PNEUMONIAE; MALE; NEWBORN; NEWBORN DEATH; NEWBORN INFECTION; PRIORITY JOURNAL; SEPTICEMIA;

EID: 0033028478     PISSN: 13592998     EISSN: 14682052     Source Type: Journal    
DOI: 10.1136/fn.80.1.F64     Document Type: Article

References (35)

1. 1 Isaacs D, Barfield C, Clothier T, et al. Late-onset infections of infants in neonatal units. J Paediatr Child Health 1996;32:158-61.
2. 2 Hable KA, Matsen JM, Wheeler DJ, et al. Klebsiella type 33 septicemia in an infant intensive care unit. J Pediatr 1972;80:920-4.
3. 3 Kayyali MZ, Nicholson DP, Smith IM. A Klebsiella outbreak in a pediatric nursery: emergency action and preventative surveillance. Clin Pediatr 1972;11:422-6.
4. 4 Hill HR, Hunt CE, Matson JM. Nosocomial colonization with Klebsiella, type 26, in a neonatal intensive care unit associated with an outbreak of sepsis, meningitis and necrotizing enterocolitis. J Pediatr 1974;85:415-9.
5. 5 Eisenach KD, Reber RM, Eitzman DV, et al. Nosocomial infections due to kanamycin-resistant, (R)-factor carrying enteric organisms in an intensive care nursery. Pediatrics 1972;50:395-402.
6. 6 Shamseldin el Shafie S, Smith W, Donnelly G. An outbreak of gentamicin-resistant Klebsiella pnuemoniae in a neonatal ward. Cent Eur J Pub Health 1995;3:129-31.
7. 7 Fidel-Rimon O, Leibovitz E, Juster-Reicher A, et al. An outbreak of multiresistant Klebsiella at the Neonatal Intensive Care Unit, Kaplan Hospital, Rehovot, Israel, November 1991 April 1992. Am J Perinatol 1996;13:99-102.
8. 8 French GL Shannon KP, Simmons J. Hospital outbreak of Klebsiella pneumoniae resistant to broad-spectrum cephalosporins and beta-lactam-beta-lactamase inhibitor combinations by hyperproduction of SHV-5 beta-lactamase. J Clin Microbiol 1996;34:358-63.
9. 9 Hobson RP, MacKenzie FM, Gould IM. An outbreak of multiply resistant Klebsiella pneumoniae ín the Grampians region of Scotland. J Hosp Infect 1996;33:249-62.
10. 10 Smith PJ, Brookfield DSK, Shaw DA, et al. An outbreak of Serratia marcescens infection in a neonatal unit. Lancet 1984;i:151-3.
11. 11 Adams BG, Marrie TJ. Hand carriage of aerobic gram-negative rods may not be transient. J Hyg 1982;89:33-46.
12. 12 Rapkin RH. Pseudomonas cepacia in an intensive care nursery. Pediatrics 1976;57:239-43.
13. 13 Drewitt SE, Payne DJH, Tuke W, et al. Eradication of Pseudomonas aeruginosa infection from a special care nursery. Lancet 1972; i:946-8.
14. 14 Stone JW, Das BC. Investigation of an outbreak of infection with Acinetobacter calcoaceticus in a special care baby unit. J Hosp Infect 1985;6:42-8.
15. 15 Anagnostakis D, Fitsialos J, Koutsia C, et al. A nursery outbreak of Serratia marcescens infection. Evidence of a single source of contamination. Am J Dis Child 1981;135:413-5.
16. 16 Archibald L K, Corl A, Shah B, et al. Serrratia marcescens outbreak associated with extrinsic contamination of 1% chlorxylenol soap. Infect Control Hosp Epidemiol 1997;18:704-9.
17. 17 Goldmann DA, Leclair J, Macone A. Bacterial colonization of neonates admitted to an intensive care environment. J Pediatr 1978;93:288-93.
18. 18 Oxley VM, Bird TJ, Grieble HG et al. Hospital isolates of Serratia marcescens transferring ampicillin, carbenicillin and gentamicin resistance to other Gram-negative bacteria including Pseudomonas aeruginosa. Antimicrob Agents Chemother 1979;15:93-100.
19. 19 Franco JA, Eitzman DV, Baer H, et al. Antibiotic usage and microbial resistance in an intensive care nursery. Am J Dis Child 1973;126:318-21.
20. 20 Cook LN, Davis RS, Stover BH. Outbreak of amikacin-resistant enterobacteriaceae in an intensive care nursery. Pediatrics 1980;65:264-8.
21. 21 Payne DJ, Amyer SB. Transferable resistance to extended spectrum β-lactamase: A major threat or minor inconvenience? J Amimicrob Chemother 1990;27:255-61.
22. 22 Modi N, Damjanovic V, Cooke RW. Outbreak of cephalosporin resistant Enterobacter cloacae infection in a neonatal intensive care unit. Arch Dis Child 1987;62:148-51.
23. 23 Jacoby GA. Antimicrobial resistant pathogens in the 1990s. Ann Rev Med 1996;47:169-79.
24. 24 Pena C, Pujol M, Ardanuy C, et al. Epidemiology and successful control of a large outbreak due to Klebsiella pneumoniae producing extended spectrum β lactamases: Are we losing the battle? Aust J Med Sci 1995;16: 16-25.
25. 25 Tristam S. Extended spectrum β-lactamases : Are we losing the battle? Antimicrob Agents Chemother 1998;42:53-8.
26. 26 Martinez-Martinez I., pascual A, Jacoby GA. Quinolone resistance from a transferable plasmid. Lancet 1998;i: 797-9.
27. 27 Peter G, Cashore WJ. Infections acquired in the nursery: epidemiology and control. In: Remington JS, Klein JO. Infectious diseases of the fetus and newborn infant. 4th edn. Philadelphia, W B Saunders, 1995:1275.
28. 28 Quinn J P. Clinical significance of extended spectrum β-lactamases. Eur J Clin Microbiol Infect Dis 1994;13:39-42.
29. 29 Franco JA, Eitzman DV, Baer H, et al. Antibiotic usage and microbial resistance in an intensive care nursery. Am J Dis Child 1973;126:318-21.
30. 30 Raz R, Sharir R, Shilowitz I., et al. The elimination of gentamicin-resistant Gram negative bacteria in a newborn intensive care unit. Infection 1987;15:32-4.
31. 31 Pritchard RC, Raper RF. Doctors and handwashing: instilling Semmelweis' message. Med J Aust 1996;164:389-90.
32. 32 Albert RK, Condie F. Hand-washing patterns in medical intensive-care units. N Engl J Med 1981;304:1465-6.
33. 33 Doebbeling BN, Stanley GL, Sheetz CT, et al. Comparative efficacy of alternative hand-washing agents in reducing nosocomial infections in intensive care units. N Engl J Med 1992;327:88-93.
34. 34 Goldmann D, Larson E. Handwashing and nosocomial infections. N Engl J Med 1992; 327:120-2.
35. 35 Tibballs J. Teaching hospital medical staff to handwash. Med J Aust 1996; 164: 395-8.