Glutamate decarboxylase isoforms in thalamic nuclei in lethargic mouse model of absence seizures

Molecular Brain Research

Volumn 71, Issue 1, 1999, Pages 127-130

  Lin, Fu Hsiung ^a   Lin, Susie ^a   Wang, Ying ^a   Hosford, David A ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Absence seizure; Glutamate decarboxylase; Lethargic mouse; Aminobutyric acid

Indexed keywords

4 AMINOBUTYRIC ACID; GLUTAMATE DECARBOXYLASE;

ABSENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONTROLLED STUDY; HYPOTHESIS; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; LETHARGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; THALAMUS NUCLEUS;

EID: 0033028367     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(99)00176-X     Document Type: Article

References (19)

1. Asada H., Kawamura Y., Maruyama K., Kume H., Ding R., Ji F.Y., Kanbara N., Kuzume H., Sanbo M., Yagi T., Obata K. Mice lacking the 65-kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures. Biochem. Biophys. Res. Commun. 229:1996;891-895.
2. Asada H., Kawamura Y., Maruyama K., Kume H., Ding R., Kanbara N., Kuzume H., Sanbo M., Yagi T., Obata K. Cleft palate and decreased brain gamma-aminobutyic acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase. Proc. Natl. Acad. Sci. U.S.A. 94:1997;6496-6499.
3. 2+ channel β subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (lh) mouse. Cell. 88:1997;385-392.
4. B mechanisms in animal models of absence seizures. Mol. Neurol. 13:1996;23-32.
5. Chapman E.R., An S., Barton N., Jahn R. SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils. J. Biol. Chem. 269:1994;27427-27432.
6. Esclapez M., Tillakaratne N.J.K., Kaufmann D.l., Tobin A.J., Houser C.R. Comparative localization of forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms. J. Neurosci. 12:1994;1834-1855.
7. Faulkner-jones B.E., Cram D.S., Kun J., Harrison L.C. Location and quantitation of expression of two glutamate decarboxylase genes in pancreatic cells and other peripheral tissues of mouse and rat. Endocrinology. 133:1993;2962-2972.
8. Feldblum S., Ackermann F.F., Tobin A.J. Long-term increase of glutamate decarboxylase mRNA in a rat model of temporal lobe epilepsy. Neuron. 5:1990;361-371.
9. 67 mRNAs suggest that the two glutamate decarboxylase play distinctive functional roles. J. Neurosci. Res. 34:1993;689-706.
10. B receptor activation in absence seizures of lethargic (lh/lh)mice. Science. 257:1992;398-401.
11. A receptors in thalamic nuclei in lh/lh model of absence seizures. Epilepsy Res. 27:1997;55-65.
12. Houser C.R., Vaughn J.E., Barker R.P., Roberts E. GABA neurons are the major cell type of the nucleus reticularis thalami. Brain Res. 200:1980;431-435.
13. B receptors in the lethargic (lh/lh) mouse model of absence epilepsy. Brain Res. 608:1993;101-106.
14. Lin F-H., Barun S., Hosford D.A. Expression of voltage-dependent calcium channel subunits α1A, β1, β2 and β3 in lethargic mouse model of absence seizures. Soc. Neurosci. 24:1998;1824.
15. Litwak J., Mercugliano M., Chesselet M.-F., Oltmans G.A. Increased glutamic acid decarboxylase (GAD) mRNA and GAD activity in cerebellar Purkinje cells following lesion-induced increase in cell firing. Neurosci. Lett. 116:1990;179-183.
16. 1B and β subunits in epileptic lethargic (lh/lh) mouse. J. Biol.Chem. 273:1998;21435-21438.
17. Segovia J., Tillakaratne N.J.K.T., Whelan K., Tobin A.J., Gale K. Parallel increases in striatal glutamic acid decarboxylase activity and mRNA levels in rats with lesions of the nigrostriatal pathway. Brain Res. 529:1990;345-348.
18. Shetty A.K., Turner D.A. Hippocampal interneurons expressing glutamic acid decarboxylase and calcium-binding proteins decrease with aging in Fischer 344 rats. J. Comp. Neurol. 394:1998;254-269.
19. B. Slotnick, C.M. Leonard (Eds.), A Stereotaxic Atlas of the Albino Mouse Forebrain, ADAMHA Press, Rockville, MD, 1975.