Novel terpenoid-type quinones isolated from Pycnanthus angolensis of potential utility in the treatment of type 2 diabetes

Journal of Pharmacology and Experimental Therapeutics

Volumn 288, Issue 2, 1999, Pages 529-534

  Luo, Jian ^a   Cheung, Jeanne ^a   Yevich, Eileen M ^a   Clark, John P ^a   Tsai, Joyce ^a   Lapresca, Priscilla ^a   Ubillas, Rosa P ^a   Fort, Diana M ^a   Carlson, Thomas J ^a   Hector, Richard F ^a   King, Steven R ^a   Mendez, Christopher D ^a   Jolad, S D ^a   Reaven, Gerald M ^a  

^a Shaman Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

QUINONE DERIVATIVE; SP 18904; SP 18905; TERPENOID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES CONTROL; DRUG EFFECT; DRUG ISOLATION; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN METABOLISM; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PLANT LEAF; PRIORITY JOURNAL;

ADIPOCYTES; ANIMALS; BLOOD GLUCOSE; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; EATING; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MICE; MICE, INBRED C57BL; NAPHTHOQUINONES; PLANT EXTRACTS; PLANTS, MEDICINAL; TREES;

EID: 0033028119     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Akendengue B and Louis AM (1994) Medicinal plants used by the Masango people in Gabon. J Ethnopharmacol 41:193-200.
2. Chang AY, Wyse BM, Gilchrist BJ, Peterson T and Diani AR (1983) Ciglitazone, a new hypoglycemic agent. I. Studies in ob/ob and db/db mice, diabetic Chinese hamsters, and normal and streptozotocin-diabetic rats. Diabetes 32:830-838.
3. Frost SC and Lane MD (1985) Evidence for the involvement of vicinal sulfhydryl groups in insulin-activated hexose transport by 3T3-L1 adipocytes. J Biol Chem 260:2646-2652.
4. Gill GV (1991) Non-insulin-dependent diabetes mellitus, in Textbook of Diabetes (Pickup J and William G eds) pp 24-34, Blackwell Scientific Publications, London.
5. Imura H (1998) A novel antidiabetic drug, troglitazone: Reason for hope and concern. N Engl J Med 338:908-909.
6. Luo J, Fort DM, Carlson TJ, Noamesi BK, nii-Amon-Kotei D, King SR, Tsai J, Quan J, Hobensack C, Lapresca P, Waldeck N, Mendez CD, Jolad SD, Bierer DE and Reaven GM (1998a) Cryptolepis sanguinolenta: An ethnobotanical approach to drug discovery and the isolation of a potentially useful new antihyperglycaemic agent. Diabetic Med 15:367-374.
7. Luo J, Quan J, Tsai J, Hobensack CK, Sullivan C, Hector RF and Reaven GM (1998b) Non-genetic mouse models of non-insulin-dependent diabetes mellitus. Metabolism 47:663-668.
8. Oubré AY, Carlson TJ, King SR and Reaven GM (1997) From plant to patient: An ethnomedical approach to the identification of new drugs for the treatment of NIDDM. Diabetologia 40:614-617.
9. Reaven GM (1995) Pathophysiology of insulin resistance in human disease. Physiol Rev 75:473-486.
10. Rossini AA, Appel MC, Williams RM and Like AA (1977) Genetic influence of the streptozotocin-induced insulitis and hyperglycemia. Diabetes 26:916-920.
11. Saltiel AR and Olefsky JM (1996) Thiazolidinediones in the treatment of insulin resistance and type II diabetes. Diabetes 46:1661-1669.
12. Shafrir E (1992) Animal models of non-insulin-dependent diabetes. Diabetes Metab Rev 8:179-208.