Effects of the new potassium channel opener JTV-506 on coronary vessels in vitro and in vivo

Arzneimittel-Forschung/Drug Research

Volumn 49, Issue 3, 1999, Pages 199-206

  Hirata, Yukiya ^a   Kanada, Atsunori ^a   Miyai, Hisato ^a   Mabuchi, Yukiyo ^a   Aisaka, Kazuo ^a  

^a JAPAN TOBACCO INC   (Japan)

Author keywords

( ) (3S,4R) 2,2 Bis(methoxymethyl) 4 (1,6 dihydro 1 methyl 6 oxo 3 pyridazinyl)amino 3 hydroxychroman 6 carbonitrile hemihydrate; CAS 170148 29 5; Coronary arteries; JTV 506, dog, vascular effects; Potassium channel opener

Indexed keywords

4 [(1,6 DIHYDRO 1 METHYL 6 OXO 3 PYRIDAZINYL)AMINO] 3 HYDROXY 2,2 BIS(METHOXYMETHYL)CHROMAN 6 CARBONITRILE; GLIBENCLAMIDE; LEMAKALIM; NICORANDIL; NIFEDIPINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT;

ANGINA PECTORIS; ANIMAL MODEL; ANIMAL TISSUE; ARTERY DIAMETER; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY CIRCUMFLEX BRANCH; CORONARY ARTERY DILATATION; CORONARY ARTERY SPASM; DOG; DOSE RESPONSE; DRUG ANTAGONISM; DRUG POTENCY; DRUG STRUCTURE; FEMALE; MALE; NONHUMAN; SWINE; TREATMENT OUTCOME;

EID: 0033027966     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1300402     Document Type: Article

References (41)

1. Prinzmetal, M., Kennamer, R., Merliss, R. et al., Am. J. Med. 27, 375 (1959)
2. Dhurandhar, R. W., Watt, D., Silver, M. et al., Am. J. Cardiol. 30, 902 (1972)
3. Meller, H., Pickad, A., Dack, S., Am. J. Cardiol. 37, 938 (1976)
4. Yasue, H., Omote, S., Takizawa, A. et al., Circulation 59, 938 (1979)
5. Specchia, G., De Servi, S., Falcone, C. et al., Circulation 59, 948 (1979)
6. Shepherd, J. T., Vanhoutte, P. M., Mayo Clin. Proc. 60, 33 (1985)
7. Kalsner, S., Biochem. Pharmacol. 49, 859 (1995)
8. Kalsner, S., Richards, R., Science 223, 1435 (1984)
9. Vanhoutte, P. M., Shimokawa, H., Circulation 80, 1 (1989)
10. Toyo-oka, T., Aizawa, T., Suzuki, N. et al., Circulation 83, 476 (1991)
11. Robertson, R. M., Robertson, D., Roberts, L. J. et al., N. Engl. J. Med. 304, 998 (1981)
12. Cho, H., Kato, S., Sayama, S. et al., J. Med. Chem. 39, 3797 (1996)
13. Quast, U., Cook, N. S., Trends Pharmacol. Sci. 10, 431 (1989)
14. Longman, S. D., Hamilton, T. C., Med. Res. Rev. 12, 73 (1992)
15. Edwards, G., Weston, A. H., Annu. Rev. Pharmacol. Toxicol. 33, 597 (1993)
16. Challinor-Rogers, J. L., McPherson, G. A., Clin. Exp. Pharmacol. Physiol. 21, 583 (1994)
17. Hirata, Y., Aisaka, K., J. Cardiovasc. Pharmacol. 29, 397 (1997)
18. Noguchi, K., Tomoike, H., Ootsubo, H. et al., J. Pharmacol. Exp. Ther. 219, 809 (1981)
19. Vatner, S. F., Hintze, T. H. et al., Circulation 66, 579 (1982)
20. Giudicelli, J. F., Rochelle, C. D., Berdeaux, A., J. Pharmacol. Exp. Ther. 255, 836 (1990)
21. Akai, K., Wang, Y., Sato, K. et al., J. Cardiovasc. Pharmacol. 26, 541 (1995)
22. Weir, S. W., Weston, A. H., Br. J. Pharmacol. 88, 121 (1986)
23. Bray, K. M., Weston, A. H., Duty, S. et al., Br. J. Pharmacol. 102, 337 (1991)
24. Yanagisawa, T., Teshigahara, T., Taira, N., Br. J. Pharmacol. 101, 157 (1990)
25. Satoh, K., Mori, T., Yamada, H. et al., Cardiovasc. Drugs Ther. 7, 691 (1993)
26. Yamashita, T., Masuda, Y., Tanaka, S., J. Cardiovasc. Pharmacol. 24, 914 (1994)
27. Yamagishi, T., Yanagisawa, T., Taira, N., Biochem. Biophys. Res. Commun. 187, 1517 (1992)
28. Itoh, T., Seki, N., Suzuki, S. et al., J. Physiol. 451, 307 (1992)
29. Itoh, T., Suzuki, S., Kuriyama, H., Br. J. Pharmacol. 103, 1697 (1991)
30. Okada, Y., Yanagisawa, T., Taira, N., Naunyn-Schmiedeberg's Arch. Pharmacol. 347, 438 (1993)
31. Okada, Y., Yanagisawa, T., Yamagishi, T. et al., Arch. Int. Pharmacodyn. 326, 33 (1993)
32. Buckingham, R. E., Hamilton, T. C., Howlett, S. et al., Br. J. Pharmacol. 97, 57 (1989)
33. Cavero, I., Mondot, S., Mestre, M., J. Pharmacol. Exp. Ther. 248, 1261 (1989)
34. Miwa, A., Kaneta, S., Motoki, K. et al., Br. J. Pharmacol. 109, 632 (1993)
35. Uchida, Y., Nakamura, F., Tomaru, T. et al., Jap. Heart J. 27, 727 (1986)
36. Cohen, M. V., Sonnenblick, E. H., Kirk, E. S., Am. J. Cardiol. 38, 880 (1976)
37. Gallagher, K. P., Forts, J. D., Shebuski, R. J. et al., Am. J. Cardiol. 46, 67 (1980)
38. Wilcken, D. E. L., Paoroni, H. J., Eikens, E., Aust. N. Z. J. Med. 1, 8 (1971)
39. Fam, W. M., McGregor, M., Circ. Res. 22, 49 (1968)
40. Berdeaux, A., La Rochelle, C. D., Richard, V. et al., J. Cardiovasc. Pharmacol. 20 (Suppl. 3), S17 (1992)
41. Uchida, W., Hirano, Y., Taguchi, T. et al., Eur. J. Pharmacol. 264, 285 (1994)