The signal transduction pathway from Porphyromonas gingivalis LPS-stimulated gingivalis fibroblasts to osteoclast activation

Medical Science Research

Volumn 27, Issue 5, 1999, Pages 311-313

  Wang, Pao Li ^a,b   Shirasu, Shinya ^a   Shinohara, Mitsuki ^a   Daito, Michiharu ^b   Kikuchi, Masanori ^b   Suetsugu, Yasushi ^b   Tanaka, Jyunzo ^c   Ohura, Kiyoshi ^c  

^a Department of Pharmacology ^*  (Japan)

^b OSAKA DENTAL UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE FOR MATERIALS SCIENCE   (Japan)

Author keywords

Cytokine; Periodontal disease; Porphyromonas gingivalis

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; HYDROXYAPATITE; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR;

ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; FIBROBLAST; FLOW CYTOMETRY; GINGIVA; HUMAN; HUMAN CELL; NONHUMAN; OSTEOCLAST; PORPHYROMONAS GINGIVALIS; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); PORPHYROMONAS GINGIVALIS;

EID: 0033027783     PISSN: 02698951     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Ishikawa I, Nakashima K, Koseki T, Nagawasa T, Watanabe H, Arakawa S, et al. Induction of the immune responses to periodontopathic bacteria and its role in the pathogenesis of periodontitis. In: Page RC, Kornman KS (editors): Periodontology 2000. Vol 14. Copenhagen: Munksgaard Press; 1997. pp. 79-111.
2. Takada H, Mihara J, Morisaki I, Hamada S. Production of cytokines by human gingival fibroblasts. In: Hamada S, Holt SC, McGhee JR (editors): Periodonlal disease. Tokyo, Japan: Quintessence Publishing Co Press; 1991. pp. 265-276.
3. Takada H, Mihara J, Morisaki I, Hamada S. Induction of interleukin-1 and -6 in human gingival fibroblast cultures stimulated with Bacteroides lipopolysaccharides. Infect Immunol 1991; 59:295-301.
4. Tamura M, Tokuda M, Nagoaka S, Takada H. Lipopolysaccharides of Bacteroides intermedium (Preollella intermedia) and Bacteroides (Porphyromonas) gingivalis induce interleukin-8 gene expression in human gingival fibroblast cultures. Infect Immunol 1992; 60:4932-4937.
5. Wang PL. Sato K, Oido M, Fujii T, Kowashi Y, Shinohara M, et al. Involvement of CD 14 on human gingival fibroblasts in Porphyromonas gingivalis lipopolysaccharide-mediated interleukin-6 secretion. Archs OralBiol 1998:43:687-694.
6. Ishimi Y. Miyaura C, Jin CH, Akatsu T, Abe E, Nakamura Y, et al. IL6 is produced by osteoblasts and induces bone résorption. J Immunol 1990; 145:3297-3303.
7. Wiebe SH, Hafezi M, Sandhu HS, Sims SM, Dixon SJ. Osteoclast activation in inflammatory periodontal diseases. Oral Disease 1996; 2:167-180.
8. Westphal O, Jann K. Bacterial lipopolysaccharides extraction with phenol-water and further applications of the procedure. Meth Carbohydr Chem 1965:5:83-91.
9. Kakudo S. Miyazawa K, Kameda T, Mano H. Mori Y, Yuasa T, et al. Isolation of highly enriched rabbit osteoclasts from collagen gels: A new assay system for bone-resorbing activity of mature osteoclasts. J Bone Miner Metab 1996; 14:129-136.
10. Appelmelk BJ, An YQ, Geerts M, Thijs BG, Boer HA, Maclaren DM. et al. Lactoferrin is a lipid a-binding protein. Infect Immunol 1994; 62:2628-2632.
11. Kapuscinski J, Skoczylas B. Simple and rapid fluorimetric method for DNA microassay. Anal Kochern 1977; 83:252-257.
12. Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, et al. Interleukin-6 triggers the association of its receptor with a possible signal transducer. gp!30. Cell 1989; 58:573-581.