Uses of antibody panels in the analysis of metastatic carcinomas of unknown primary

Acta Histochemica et Cytochemica

Volumn 32, Issue 2, 1999, Pages 153-159

  Gown, Allen M ^a,b,c  

^a PHENOPATH LABORATORIES   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Carcinoma; CEA; Cytokeratins; Estrogen receptor; Immunohistochemistry

Indexed keywords

EID: 0033024219     PISSN: 00445991     EISSN: None     Source Type: Journal    
DOI: 10.1267/ahc.32.153     Document Type: Conference Paper

References (36)

1. Albores-Saavedra, J., Nadji, M., Civantos, F. and Morales, A. R.: Thyroglobulin in carcinoma of the thyroid: an immunohistochemical study. Hum. Pathol. 14; 62-66, 1983.
2. Ascoli, V., Taccogna, S., Scalzo, C. C. and Nardi, F.: Utility of cytokeratin 20 in identifying the origin of metastatic carcinomas in effusions. Diagn. Cytopathol. 12; 303-308, 1995.
3. Azumi, N., Traweek, S. T. and Battifora, H.: Prostatic acid phosphatase in carcinoid tumors, Immunohistochemical and immunoblot studies. Am. J. Surg. Pathol. 15; 785-790, 1991.
4. Bejarano, P. A., Baughman, R. P., Biddinger, P. W., Miller, M. A., Fenoglio, Preiser, C., al, Kafaji, B., Di, Lauro R. and Whitsett, J. A.: Surfactant proteins and thyroid transcription factor-1 in pulmonary and breast carcinomas. Mod. Pathol. 9; 445-452, 1996.
5. Berezowski, K., Stastny, J. F. and Kornstein, M. J.: Cytokeratins 7 and 20 and carcinoembryonic antigen in ovarian and colonic carcinoma. Mod. Pathol. 9; 426-429, 1996.
6. Chang, K., Pastan, I. and Willingham, M. C.: Isolation and characterization of a monoclonal antibody, K1, reactive with ovarian cancers and normal mesothelium. Int. J. Cancer 50; 373-381, 1992.
7. Chang, K., Pai, L. H., Pass, H., Pogrebniak, H. W., Tsao, M. S., Pastan, I. and Willingham, M. C.: Monoclonal antibody K1 reacts with epithelial mesothelioma but not with lung adenocarcinoma. Am. J. Surg. Pathol. 16; 259-268, 1992.
8. Clover, J., Oates, J. and Edwards, C.: Anti-cytokeratin 5/6: a positive marker for epithelioid mesothelioma. Histopathology 31; 140-143, 1997.
9. Deamant, F. D., Pombo, M. T. and Battifora, H.: Estrogen receptor immunohistochemistry as a predictor of site of origin in metastatic breast cancer. Appl. Immunohistochem. 1; 188-192, 1993.
10. Diaz, N. M., Mazoujian, G. and Wick, M. R.: Estrogen-receptor protein in thyroid neoplasms. An immunohistochemical analysis of papillary carcinoma, follicular carcinoma, and follicular adenoma. Arch. Pathol. Lab. Med. 115; 1203-1207, 1991.
11. Domagala, W., Lasota, J., Bartkowiak, J., Weber, K. and Osborn, M.: Vimentin is preferentially expressed in human breast carcinomas with low estrogen receptor and high Ki-67 growth fraction. Am. J. Pathol. 136; 219-227, 1990.
12. Fabbro, D., Di, Loreto, C., Stamerra, O., Beltrami, C. A., Lonigro, R. and Damante, G.: TTF-1 gene expression in human lung tumours. Eur. J. Cancer 3; 512-517, 1996.
13. Gabbiani, G., Kapanci, Y., Barazzone, P. and Franke, W. W.: Immunochemical identification of intermediate-size filaments in human neoplastic cells. A diagnostic aid for the surgical pathologist. Am. J. Pathol. 104; 206-216, 1981.
14. Gown, A. M. and Vogel, A. M.: Monoclonal antibodies to human intermediate filament proteins. II. Distribution of filament proteins in normal human tissues. Am. J. Pathol. 114; 309-321, 1984.
15. Gown, A. M. and Vogel, A. M.: Monoclonal antibodies to human intermediate filament proteins. III. Analysis of tumors. Am. J. Clin. Pathol. 84; 413-424, 1985.
16. Grunert, F., Daniel, S., Nagel, G., von-Kleist, S. and Jantscheff, P.: CD66b, CD66c and carcinoembryonic antigen (CEA) are independently regulated markers in sera of tumor patients. Int. J. Cancer 63; 349-355, 1995.
17. Guerrieri, C., Franlund, B. and Boeryd, B.: Expression of cytokeratin 7 in simultaneous mucinous tumors of the ovary and appendix. Mod. Pathol. 8; 573-576, 1995.
18. Howarth, D. J., Aronson, I. B. and Diamandis, E. P.: Immunohistochemical localization of prostate-specific antigen in benign and malignant breast tissues. Br. J. Cancer 75; 1646-1651, 1997.
19. Loy, T. S. and Calaluce, R. D.: Utility of cytokeratin immunostaining in separating pulmonary adenocarcinomas from colonic adenocarcinomas. Am. J. Clin. Pathol. 102; 764-767, 1994.
20. Loy, T. S., Calaluce, R. D. and Keeney, G. L.: Cytokeratin immunostaining in differentiating primary ovarian carcinoma from metastatic colonic adenocarcinoma. Med. Pathol. 9; 1040-1044, 1996.
21. Moll, R., Lowe, A., Laufer, J. and Franke, W. W.: Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies. Am. J. Pathol. 140; 427-447,1992.
22. Nadji, M., Tabei, Z., Castro, A. and Morales, A. R.: Immunohistological demonstration of prostatic origin of malignant neoplasms [letter]. Lancet 1; 671-672, 1979.
23. Nadji, M., Tabei, S. Z., Castro, A., Chu, T. M., Murphy, G. P., Wang, M. C. and Morales, A. R.: Prostatic-specific antigen: an immunohistologic marker for prostatic neoplasms. Cancer 48; 1229-1232, 1981.
24. Nicholson, A. G., McCormick, C. J., Shimosato, Y., Butcher, D. N. and Sheppard, M. N.: The value of PE-10, a monoclonal antibody against pulmonary surfactant, in distinguishing primary and metastatic lung tumours. Histopathology 27; 57-60, 1995.
25. Ordonez, N.: Value of cytokeratin 5/6 irnmunostaining in distinguishing epithelial mesothelioma of the pleura from lung adenocarcinoma. Am. J. Surg. Pathol. 22; 1215-1221, 1998.
26. Quinlan, R. A., Schiller, D. L., Hatzfeld, M., Achtstatter, T., Moll, R., Jorcano, J. L., Magin, T. M. and Franke, W. W.: Patterns of expression and organization of cytokeratin intermediate filaments. Ann. NY Acad. Sci. 455; 282-306, 1985.
27. Raab, S. S., Berg, L. C., Swanson, P. E. and Wick, M. R.: Adenocarcinoma in the lung in patients with breast cancer. A prospective analysis of the discriminatory value of immunohistology [see comments]. Am. J. Clin. Pathol. 100; 27-35, 1993.
28. Ramaekers, F., van, Neikerk, C., Poels, L., Schaafsma, E., Huijsmans, A., Robben, H., Schaart, G. and Vooijs, P.: Use of monoclonal antibodies to keratin 7 in the differential diagnosis of adenocarcinomas. Am. J. Pathol. 136; 641-655, 1990.
29. Ronnett, B. M., Kurman, R. J., Shmookler, B. M., Sugarbaker, P. H. and Young, R. H.: The morphologic spectrum of ovarian metastases of appendiceal adenocarcinomas: a clinicopathologic and immunohistochemical analysis of tumors often misinterpreted as primary ovarian tumors or metastatic tumors from other gastrointestinal sites. Am. J. Surg. Pathol. 21; 1144-1155, 1997.
30. Swanson, P. E., Mazoujian, G., Mills, S. E., Campbell, R. J. and Wick, M. R.: Immunoreactivity for estrogen receptor protein in sweat gland tumors. Am. J. Surg. Pathol. 15; 835-841, 1991.
31. Ueda, G., Sawada, M., Ogawa, H., Tanizawa, O. and Tsujimoto, M.: Immunohistochemical study of cytokeratin 7 for the differential diagnosis of adenocarcinomas in the ovary. Gynecol. Oncol. 51; 219-223, 1993.
32. van-Niekerk, C. C., Jap, P. H., Ramaekers, F. C., vande-Molengraft, F. and Poels, L. G.: Immunohistochemical demonstration of keratin 7 in routinely fixed paraffin-embedded human tissues. J. Pathol. 165; 145-152, 1991.
33. Viale, G., Doglioni, C., Gambacorta, M., Zamboni, G. and Bordi, C.: Progesterone receptor immunoreactivity in pancreatic endocrine tumors. An immunocytochemical study of 156 neuroendocrine tumors of the pancreas, gastrointestinal and respiratory tracts, and skin. Cancer 70; 2268-2277, 1992.
34. Wang, N. P., Bacchi, C. E. and Gown, A. M.: Coordinate expression of cytokeratins 7 and 20 define unique subsets of carcinomas. Appl. Immunohistochem. 3; 99-107, 1995.
35. Watt, S. M., Sala Newby, G., Hoang, T., Gilmore, D. J., Grunert, F., Nagel, G., Murdoch, S. J., Tchilian, E., Lennox, E. S. and Waldmann, H.: CD66 identifies a neutrophil-specific epitope within the hematopoietic system that is expressed by members of the carcinoembryonic antigen family of adhesion molecules. Blood 78; 63-74, 1991.
36. Wick, M. R., Lillemoe, T. J., Copland, G. T., Swanson, P. E., Manivel, J. C. and Kiang, D. J.: Gross cystic disease fluid protein-15 as a marker for breast cancer: immunohistochemical analysis of 690 human neoplasms and comparison with alpha-lactalbumin. Hum. Pathol. 20; 281-287, 1989.