Overexpression of c-Met protein in human thyroid tumors correlated with lymph node metastasis and clinicopathologic stage

Pathology Research and Practice

Volumn 195, Issue 6, 1999, Pages 427-433

  Chen, Bing Kun ^a   Ohtsuki, Yuji ^a   Furihata, Mutsuo ^a   Takeuchi, Tamotsu ^a   Iwata, Jun ^a   Liang, Sheng Ben ^a   Sonobe, Hiroshi ^a  

^a KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

c Met; Follicular adenoma (FA); Immunohistochemistry; Lymph node metastasis (LNM); Papillary thyroid carcinoma (PTC)

Indexed keywords

MEMBRANE PROTEIN; SCATTER FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGE; AGED; ARTICLE; CELL NUCLEUS; CYTOPLASM; DIFFERENTIAL DIAGNOSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PROTEIN EXPRESSION; SEX; THYROID ADENOMA; THYROID CARCINOMA; TISSUE SECTION; TUMOR VOLUME;

EID: 0033023940     PISSN: 03440338     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0344-0338(99)80017-X     Document Type: Article

References (37)

1. Befiore A, Gangemi P, Costantino A, Russo G, Santonocito GM, Ippolito O, Di Renzo MF, Comoglio P, Fiumara A, Vigneri R (1997) Negative /Low Expression of the Met/Hepatocyte Growth Factor Receptor Identifies Papillary Thyroid Carcinomas with High Risk of Distant Metastases. J Clin Endocrinol Metab 82: 2322-2328
2. Beviglia L, Matsumoto K, Lin CS, Ziober BL, Kramer RH (1997) Expression of the c-Met/HGF receptor in human breast carcinoma: Correlation with tumor progression. Int J Cancer (Pred Oncol) 74: 301-309
3. Cady B, Sedgwick CE, Meisner WA, Brokwatter JR, Romagosa V, Werber J ( 1976) Changing clinical pathologic, therapeutic, and survival patterns in differentiated thyroid carcinoma. Ann Surg 184: 541
4. Carcangiu ML, Zampi G, Pupi A, Castagnoli A, Rosai J (1985) Papillary carcinoma of the thyroid. A clinicopathologic study of 241 cases treated at the University of Florence, Italy. Cancer 55: 805-828
5. Clark OH (1996) Predictors of thyroid tumor aggressiveness. West J Med 165: 131-138
6. Di Renzo MF, Narsimhan RP, Olivero M, Bretti S, Giordano S, Medico E, Gaglia P, Zara P, Comoglio PM (1991) Expression of the Met/HGF receptor in normal and neoplastic human tissues. Oncogene 6: 1997-2003
7. Di Renzo MF, Olivero M, Ferro S, Prat M, Bongarzone I, Pilotti S, Belfiore A, Costantino A, Vigneri R, Pierotti MA, Comoglio PM (1992) Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas. Oncogene 7: 2549-2553
8. Di Renzo MF, Olivero M, Giacomini A, Porte H, Chastre E, Mirossay L, Nordlinger B, Bretti S, Bottardi S, Giordano S, Plebani M, Gespach C, Comoglio PM (1995) Overexpression and amplification of the met/hgt receptor gene during the progression of colorectal cancer. Clin Cancer Res 1: 147-154
9. Di Renzo MF, Olivero M, Katsaros D. Crepaldi T, Ganglia P, Zola P, Sismondi P, Comoglio PM (1994) Overexpression of the MET/HGF receptor in ovarian cancer. Int J Cancer 58: 658-662
10. Di Renzo MF, Olivero M, Serini G, Orlandi F, Pilotti S, Belfiore A, Costantino A, Vigneri R, Angeli A, Pierotti MA. Comoglio PM (1995) Overexpression of the c-MET/HGF receptor in human thyroid carcinoma derived from the follicular epithelium. J Endocrinol Invest 18: 134-139
11. Di Renzo MF, Poulsom R, Olivero M, Comoglio PM, Lemoine NR (1995) Expression of the Mct/Hepatocyte Growth Factor in human pancreatic cancer. Cancer Research 55: 1129-1138
12. Dremier S, Taton M, Coulonval K, Nakamura T, Matsumoto K, Dumont JE (1994) Mitogenic, dedifferentiating, and scattering effects of hepatocyte growth factor on dog thyroid cells. Endocrinology 135: 135-140
13. Galeazzi E, Olivero M, Gervasio FC, De Stefani A, Valente G, Comoglio PM, Di Renzo MF, Cortesina G (1997) Detection of MET oncogene/hepatocyte growth factor receptor in lymph node metastases from head and neck squamous cell carcinomas. Eur Arch Otorhinolaryngol 254 (Suppl. l): S138-S143
14. Ghoussoub RA, Dillon DA, D'Aquila T, Rimm EB, Fearon ER, Rimm DL (1998) Expression of c-met is a strong independent prognostic factor in breast carcinoma. Cancer 82: 1513-1520
15. Giordano S, Di Renzo MF, Narsimhan R, Cooper CS, Rosa C, Comoglio PM (1989) Biosynthesis of the protein encoded by the c-met proto-oncogene. Oncogene 4: 1383-1388
16. Giordano S, Ponzetto C, Di Renzo MF, Cooper CS, Comoglio PM (1989) Tyrosine kinase receptor indistinguishable from the c-met protein. Nature 339: 155-156
17. 140 protein-tyrosine kinases. Proc Natl Acad Sei USA, 85: 21-25
18. Harwood J, Clark OH, Dunphy JE (1978) Significance of lymph node metastasis in differentiated thyroid cancer. Am J Surg 136: 107-110
19. Hirabayashi RN, Lindsay S (1961) Carcinoma of the thyroid gland: a statistical study of 390 patients. J Clin Endocrinol Metab 21: 1956
20. Ichimura E, Maeshima A, Nakajima T, Nakamura T (1996) Expression of c-met/HGF receptor in human non-small cell lung carcinomas in vitro and in vivo and its prognostic significance. Jpn J Cancer Res 87: 1063-1069
21. Inoue K, Chikazawa M, Karashima T, Iiyama T, Kamada M, Shuin T. Furihata M. Ohtsuki Y (1998) Overexpression of c-Met/Hepatocyte Growth Factor Receptors in human proslatic adenocarcinoma. Acta Med Okayama 52 (6): 305-310
22. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (259): 680-685
23. McHenry CR, Ohio C, Rosen IB, Walfish PG, Ontario T (1991) Prospective management of nodal metastasis in differentiated thyroid cancer. Am J Surg 162: 353-356
24. Naldini L, Weidner KM, Vigna E, Gaudino G, Bardelli A, Ponzetto C, Narsimhan RP, Hartmann G, Zarnegar R, Michalopoulos GK. Birchmeier W, Comoglio PM (1991) Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. The EMBO Journal 10: 2867-2878
25. Natali PG, Prat M, Nicotra MR, Bigotti A, Olivero M, Comoglio PM, Di Renzo MF (1996) Overexpression of the met/HGF receptor in renal cell carcinomas. Int J Cancer (Pred Oncol ) 69: 212-217
26. Oyama T, Ichimura E, Sano T, Kashiwabara K, Fukuda T, Nakajima T (1998) c-Met expression of thyroid tissue with special reference to papillary carcinoma. Pathol Int 48: 763-768
27. Prat M, Narsimhan RP, Crepaldi T, Nicotra MR, Natali PG, Comoglio PM (1991) The receptor encoded by the human c-Met oncogene is expressed in hepatocytes, epithelial cell sand solid tumors. Int J Cancer 49: 323-328
28. Ruco LP, Ranalli T, Marzullo A. Bianco P, Prat M, Comoglio PM, Baroni CD (1996) Expression of Met protein in thyroid tumors. J Pathol 180: 266-270
29. Saitoh K, Takahashi H, Sawada N. Parsons PG (1994) Detection of the c-met proto-oncogene product in normal skin and tumors of melanocytic origin. J Pathol 174: 191-199
30. Sawatsubashi M, Sasatomi E, Mizokami H, Tokunaga O, Shin T (1998) Expression of c-Met in laryngeal carcinoma. Virchows Arch 432: 331-335
31. Scheumann GFW, Gimm O, Wegener G, Hundeshagen H, Dralle H (1994) Prognostic significance and surgical management of locoregional lymph node metastases in papillary thyroid cancer. World J Surg 18: 559-568
32. Sellers M, Beenken S, Blankenship A, Soong SJ, Turbat-Herrera E, Urist M, Maddox W ( 1992) Prognostic significance of cervical lymph node metastases in differentiated thyroid cancer. Am J Surg 164: 578-581
33. Soman NR, Correa P, Ruiz BA, Wogan G (1991) The TPR-Met oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions. Proc Natl Acad Sci USA 88: 4892-4896
34. Stoker M, Gherardi E, Perryman M, Gray J (1987) Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature 327: 239-242
35. Suzuki K, Hayashi N, Yamada Y, Yoshihara H, Miyamoto Y, Ito Y, Ito T, Katayama K, Sasaki Y, Ito A, Kisida Y, Kashiwagi T, Fusamoto H, Kamada T (1994) Expression of the c-met protooncogene in human hepatocellular carcinoma. Hepatology 20: 1231-1236
36. Takanami I, Tanana, F, Hashizume T, Kikuchi K, Yamamoto Y, Yamamoto T, Kodaira S (1996) Hepatocyte growth factor and c-Met/hepatocyte growth factor receptor in pulmonary adenocarcinomas: An evaluation of their expression as prognostic markers. Oncology 53: 392-397
37. Tempest PR, Stratton MR, Cooper CS (1988) Structure of the met protein and variation of met protein kinase activity among human tumor cell. BrJ Cancer 58: 3-7