Identification of protein instability determinants in the carboxy- terminal region of c-Myb removed as a result of retroviral integration in murine monocytic leukemias

Journal of Virology

Volumn 73, Issue 3, 1999, Pages 2038-2044

  Bies, Juraj ^a,b   Nazarov, Viktor ^a,b   Wolff, Linda ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b INSTITUTE OF CHEMISTRY   (Slovakia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; LEUKEMOGENESIS; MONOCYTIC LEUKEMIA; NONHUMAN; ONCOGENE C MYB; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0033023882     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.3.2038-2044.1999     Document Type: Article

References (28)

1. Bartunek, P., V. Karafiat, M. Dvorakova, V. Zahorova, S. Mandikova, M. Zenke, and M. Dvorak. 1997. The Myb leucine zipper is essential for leukemogenicity of the v-Myb protein. Oncogene 15:2939-2949.
2. Bender, T. P., and W. M. Kuehl. 1986. Murine myb protooncogene mRNA: cDNA sequence and evidence for 5′ heterogeneity. Proc. Natl. Acad. Sci. USA 83:3204-3208.
3. Bies, J., B. Huffman, A. Amanullah, T. Giese, and L. Wolff. 1996. B-Myb prevents growth arrest associated with terminal differentiation of monocytic cells. Oncogene 12:355-363.
4. Bies, J, R. Mukhopadhyaya, J. Pierce, and L. Wolff. 1995. Only late, nonmitotic stages of granulocyte differentiation in 32Dcl3 cells are blocked by ectopic expression of murine c-myb and its truncated forms. Cell Growth Differ. 6:59-68.
5. Bies, J., and L. Wolff. 1997. Oncogenic activation of c-Myb by carboxyl-terminal truncation leads to decreased proteolysis by the ubiquitin-26S proteasome pathway. Oncogene 14:203-212.
6. Chevaillier, P. 1993. PEST sequences in nuclear proteins. Int. J Biochem 25:479-482.
7. Ferrao, P., E. M. MacMillan, L. K. Ashman, and T. J. Gonda. 1995. Enforced expression of full length c-Myb leads to density-dependent ransformation of murine haemopoietic cells. Oncogene 11:1631-1638.
8. Golay, J., L. Basilico, L. Loffarelli, S. Songia, V. Broccoli, and M. Introna. 1996. Regulation of hematopoietic cell proliferation and differentiation by the myb oncogene family of transcription factors. Int. J. Clin. Lab. Res. 26:24-32.
9. Hilt, W., and D. H. Wolf. 1996. Proteasomes: destruction as a programme. Trends Biochem. Sci. 21:96-102.
10. Hu, Y. L., R. G. Ramsay, C. Kanei-Ishii, S. Ishii, and T. J. Gonda. 1991. Transformation by carboxyl-deleted Myb reflects increased transactivating capacity and disruption of a negative regulatory domain. Oncogene 6:1549-1553.
11. Ishiguro, N., T. Ohzono, T. Shinagawa, M. Horiuchi, and M. Shinagawa. 1994. A spontaneous internal deletion of the c-myb protooncogene enhances transcriptional activation in bovine T lymphoma cells. J. Biol. Chem. 269: 26822-26829.
12. Jiang, W., M. R. Kanter, I. Dunkel, R. G. Ramsay, K. L. Beemon, and W. S. Hayward. 1997. Minimal truncation of the c-myb gene product in rapid-onset B-cell lymphoma. J. Virol. 71:6526-6533.
13. Kanel-Ishii, C., E. M. MacMillan, T. Nomura, A. Sarai, R. G. Ramsay, S. Aimoto, S. Ishii, and T. J. Gonda. 1992. Transactivation and transformation by Myb are negatively regulated by a leucine-zipper structure. Proc. Natl. Acad. Sci. USA 89:3088-3092.
14. Koch, W., G. Hunsmann, and R. Friedrich. 1983. Nucleotide sequence of the envelope gene of Friend murine leukemia virus. J. Virol. 45:1-9.
15. Koller, R., M. Krall, B. Mock, J. Bies, V. Nazarov, and L. Wolff. 1996. Mm11, a new common integration site in murine leukemia virus-induced promonocytic leukemias, maps to mouse chromosome 10. Virology 224:224-234.
16. Kubbutal, M. H., S. N. Jones, and K. H. Vousden. 1997. Regulation of p53 stability by Mdm2. Nature 387:299-303.
17. Luscher, B., and R. N. Eisenman. 1988. c-myc and c-myb protein degradation: effect of metabolic inhibitors and heat shock. Mol. Cell. Biol. 8:2504-2512.
18. Mukhopadhyaya, R., and L. Wolff. 1992. New sites of proviral integration associated with murine promonocytic leukemias and evidence for alternate modes of c-myb activation. J. Virol. 66:6035-6044.
19. Nazarov, V., and L. Wolff. 1995. Novel integration sites at the distal 3′ end of the c-myb locus in retrovirus-induced promonocytic leukemias. J. Virol. 69:3885-3888.
20. Papavassiliou, A. G., M. Treier, C. Chavrier, and D. Bohmann. 1992. Targeted degradation of c-Fos, but not v-Fos, by a phosphorylation-dependent signal on c-Jun. Science 258:1941-1944.
21. Rechsteiner, M., and S. W. Rogers. 1996. PEST sequences and regulation by proteolysis. Trends Biochem. Sci. 21:267-271.
22. Selvakumaran, M., D. A. Liebermann, and B. Hoffman-Liebermann. 1992. Deregulated c-myb disrupts interleukin-6 or leukemia inhibitory factor-in-duced myeloid differentiation prior to c-myc: role in leukemogenesis. Mol. Cell. Biol. 12:2493-2500.
23. Shen-Ong, G. L., and L. Wolff. 1987. Moloney murine leukemia virus-induced myeloid tumors in adult BALB/c mice: requirement of c-myb activation but lack of v-abl involvement. J. Virol. 61:3721-3725.
24. Tavner, F. J., R. Simpson, S. Tashiro, D. Favier, N. A. Jenkins, D. J. Gilbert, N. G. Copeland, E. M. MacMillan, J. Lutwyche, R. A. Keough, S. Ishii, and T. J. Gonda. 1998. Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role in transactivation by Myb. Mol. Cell. Biol. 18:989-1002.
25. Treier, M., L. M. Staszewski, and D. Bohmann. 1994. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain. Cell 78:787-798.
26. Wolff, L. 1996. Myb-induced transformation. Crit. Rev. Oncog. 7:245-260.
27. Wolff, L., R. Koller, J. Bies, V. Nazarov, B. Hoffman, A. Amanullah, M. Krall, and B. Mock. 1996. Retroviral insertional mutagenesis in murine promonocytic leukemias: c-myb and Mm11. Curr. Top. Microbiol. Immunol. 211:191-199.
28. Wolff, L., R. Koller, and W. Davidson. 1991. Acute myeloid leukemia induction by amphotropic murine retrovirus (4070A): clonal integrations involve c-myb in some but not all leukemias. J. Virol. 65:3607-3616.