In vitro activities of benflumetol against 158 Senegalese isolates of Plasmodium falciparum in comparison with those of standard antimalarial drugs

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 2, 1999, Pages 418-420

  Pradines, Bruno ^a   Tall, Adama ^b   Fusai, Thierry ^a   Spiegel, Andre ^b   Hienne, Remi ^a   Rogier, Christophe ^a   Trape, Jean Francois ^c   Le Bras, Jacques ^d   Parzy, Daniel ^a  

^a SERVICE DE SANTÉ DES ARMÉES   (France)

^b INSTITUT PASTEUR DE DAKAR   (Senegal)

^c INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT   (Senegal)

^d BICHAT HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMODIAQUINE; ARTEMETHER; BENFLUMETOL; CHLOROQUINE; PYRIMETHAMINE; PYRONARIDINE; QUININE;

ADULT; ARTICLE; CROSS RESISTANCE; HUMAN; MAJOR CLINICAL STUDY; MALARIA; MINIMUM INHIBITORY CONCENTRATION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SENEGAL;

EID: 0033023732     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.2.418     Document Type: Article

References (21)

1. Basco, L. K., J. Bickii, and P. Ringwald. 1998. In vitro activity of lumefantrine (benflumetol) against clinical isolates of Plasmodium falciparum in Yaounde, Cameroon. Antimicrob. Agents Chemother. 42:2347-2351.
2. Dorn, A., S. R. Vippagunta, H. Matile, C. Jaquet, J. L. Vennerstrom, and R. G. Ridley. 1998. An assessment of drug-haematin as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials. Biochem. Pharmacol. 55:727-736.
3. Fitch, C. D. 1986. Antimalarial schizonticides: ferriprotoporphyrin IX interaction hypothesis. Parasitol. Today 2:330-331.
4. Hatz, C., S. Abdulla, R. Mull, D. Scellenberg, I. Gathmann, P. Kibatala, H. P. Beck, M. Tanner, and C. Royce. 1998. Efficacy and safety of CGP 56697 (artemether and benflumetol) compared wild chloroquine to treat acute malaria in Tanzanian children aged 1-5 years. Trop. Med. Int. Health 3:498-504.
5. Jelinek, T., P. Schelbert, T. Loescher, and D. Eichenlaub. 1995. Quinine resistant falciparum malaria acquired in East Africa. Trop. Med. Parasitol. 46:38-40.
6. Marsh, K., D. Forster, C. Waruiru, I. Mwangi, M. Winstanley, V. Marsh, C. Newton, P. Winstanley, P. Warn, N. Peshu, G. Pasvol, and R. Snow. 1995. Indicators of live-threatening malaria in African children. N. Engl. J. Med. 332:1399-1404.
7. Molinier, S., P. Imbert, D. Verrot, M. Morillon, D. Parzy, and J. E. Touze. 1994. Paludisme à Plasmodium falciparum: résistance de type RI à la quinine en Afrique de l'Est. Presse Med. 23:1494.
8. Novartis Co-Artemether International Development Team. 1998. Positioning, labeling, and medical information control of co-artemether tablets (CPG 56697), a fixed novel combination of artemether and benflumetol. The rational use of qinghaosu and its derivatives, p. 99-105. In Working Papers of the International Laveran Association Conference.
9. Pradines, B., C. Rogier, T. Fusai, A. Tall, J. F. Trape, and J. C. Doury. 1996. Sensibilité in vitro de 85 isolats de Plasmodium falciparum dans la région de Fatick, Sénégal. Med. Trop. 56:141-145.
10. Pradines, B., C. Rogier, T. Fusai, A. Tall, J. F. Trape, and J. C. Doury. 1998. In vitro activity of artemether against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial drugs. Am. J. Trop. Med. Hyg. 58:354-357.
11. Pradines, B., A. Tall, D. Parzy, A. Spiegel, T. Fusai, R. Hienne, J. F. Trape, and J. C. Doury. 1998. In vitro activity of pyronaridine and amodiaquine against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial drugs. J. Antimicrob. Chemother. 42:333-339.
12. Slater, A. F. G., and A. Cerami. 1992. Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites. Nature 355:167-169.
13. Umontong, A. B., E. N. Ezedinechi, A. A. Okerengwo, E. A. Usanga, J. J. Udo, and A. I. Williams. 1991. Correlation between in vivo and in vitro response of chloroquine-resistant Plasmodium falciparum in Calabar, south-eastern Nigeria. Acta Trop. 49:119-125.
14. Van Vuggt, M., A. Brockman, B. Gemperli, C. Luxemburger, I. Gathmann, C. Royce, T. Slight, S. Looreesuwan, N. J. White, and F. Nosten. 1998. Randomized comparison of artemether-benflumetol and artesunate-mefloquine in treatment of multidrug-resistant falciparum malaria. Antimicrob. Agents Chemother. 42:135-139.
15. Von Seidlein, L., K. Bojang, P. Jones, S. Jaffar, M. Pinder, S. Obaro, T. Doherty, M. Haywood, G. Snounou, B. Gemperli, I. Gathmann, C. Royce, K. McAdam, and B. Greenwood. 1998. A randomized controlled trial of artemether/benflumetol, a new antimalarial and pyrimethamine/sulfadoxine in the treatment of uncomplicated falciparum malaria in African children. Am. J. Trop. Med. Hyg. 58:638-644.
16. Von Seidlein, L., S. Jaffar, M. Pinder, M. Haywood, G. Snounou, B. Gemperli, I. Gathmann, C. Royce, and B. Greenwood. 1997. Treatment of African children with uncomplicated falciparum malaria with a new antimalarial drug, CGP 56697. J. Infect. Dis. 176:1113-1116.
17. Ward, S. A. 1997. An overview of preclinical investigations with CGP 56697. In Proceedings of the Conference des Médecines des Voyages, Geneva, Switzerland.
18. Wernsdorfer, W. H., B. Langraf, V. A. E. B. Kilimali, and G. Wernsdorfer. 1998. Activity of benflumetol and its enantiomers in fresh isolates of Plasmodium falciparum from East Africa. Acta Trop. 70:9-15.
19. Winkler, S., C. Brandts, W. H. Wernsdorfer, W. Graniger, U. Bienzle, and P. G. Kremsner. 1994. Drug sensitivity of Plasmodium falciparum in Gabon. Activity correlations between various antimalarials. Trop. Med. Parasitol. 45:214-218.
20. World Health Organisation. 1990. Severe and complicated malaria, 2nd ed. Trans. R. Soc. Trop. Med. Hyg. 84(Suppl. 2):1-65.
21. Xiuquing, J., L. Guang-Yu, S. Cheng-Qi, Z. Xing, L. X. Wei, I. Gathmann, and C. Royce. 1997. Phase II trial in China of new, rapidly acting and effective oral antimalarial, CGP 56697, for the treatment of Plasmodium falciparum malaria. Southeast Asian J. Trop. Med. Public Health 28:476-481.