Induction of cytotoxic and helper T cell responses by modified simian immunodeficiency virus hypervariable epitope constructs

Viral Immunology

Volumn 12, Issue 2, 1999, Pages 117-129

  Meyer, Debra ^a   Torres, José V ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; PALMITIC ACID; PALMITIC ACID DERIVATIVE; SIMIAN IMMUNODEFICIENCY VIRUS VACCINE; SYNTHETIC PEPTIDE; VIRUS ENVELOPE PROTEIN; VIRUS GLYCOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; CELLULAR IMMUNITY; CONJUGATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DELAYED HYPERSENSITIVITY; FEMALE; HELPER CELL; HUMORAL IMMUNITY; IMMUNIZATION; IMMUNOGENICITY; LYMPH NODE CELL; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; SIMIAN IMMUNODEFICIENCY VIRUS; SPLEEN CELL; VIRUS ENVELOPE; VIRUS INFECTION;

ANIMALIA; RNA VIRUSES; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0033023721     PISSN: 08828245     EISSN: None     Source Type: Journal    
DOI: 10.1089/vim.1999.12.117     Document Type: Article

References (29)

1. Anderson, D.E., A. Malley, E. Benjamini, M.B. Gardner, and J.V. Torres. 1994. Hypervariable epitope constructs as a means of accounting for epitope variability. Vaccine. 12:736-740.
2. Bessler, W.G., B. Suhr, H.-J. Buhring, C.P. Muller, K.-H. Weismuller, G. Becker, and G. Jung. 1985. Specific antibodies elicited by antigen covalently linked to a synthetic adjuvant. Immunobiology. 170:239-244.
3. Byrne, J.A., and M.B.A. Oldstone. 1984. Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo. J. Virol. 51:682-686.
4. Collins, D.S., K. Findlay, and C.V. Harding. 1992. Processing of exogenous liposome-encapsulated antigens in vivo generates class I MHC-restricted T cell responses. J. Immunol. 148:3336-3341.
5. Culmann-Penciolelli, B., S. Lamhamedi-Cherradi, I. Couillin, N. Guegan, J.-P. Levy, J.G. Guillet, and E. Gomard. 1994. Identification of multi-restricted immunodominant regions recognized by cytolytic T lymphocytes in the human immunodeficiency virus type 1 nef protein. J. Virol. 68:7336-7343.
6. Grant, E.P., and K. Rock. 1992. MHC class I restricted presentation of exogenous antigen by thymic antigen presenting cells in vitro and in vivo. J. Immunol. 148:449-451.
7. Hart, M.K., K.J. Weinhold, R.M. Scearce, E.M. Wasburn, C.A. Clarck, T.J. Palker, and B.F. Haynes. 1991. Priming of anti human immunodeficiency virus (HIV) CD8+ cytotoxic T cells in vivo by carrier free HIV synthetic peptides. Proc. Natl. Acad. Sci. USA. 88:9948-9452.
8. Hosmalin, A., M. Clerici, R. Houghten, C.D. Pendleton, C. Flex, R.D. Lucey, B. Moss, R.N. German, G.M. Shearer, and J.A. Berzofsky. 1990. An epitope in human immunodeficiency virus 1 reverse transcriptase recognized by both mouse and human cytotoxic T lymphocytes. Proc. Natl. Acad. Sci. USA. 87:2344-2348.
9. Huang, A., Y.S. Tsao, S.J. Kennel, and L. Huang. 1982. Characterization of antibody covalently coupled to liposomes. Biochim. Biophys. Acta. 16:140-150.
10. Kaiser, E., R.L. Colescott, C.D. Bossinger, and P.I. Cook. 1970. Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides. Ann. Biochem. 34:595-598.
11. Kovasovics-Bankowski, M., K. Clark, B. Benaceraf, and K. Rock. 1993. Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages. Proc. Natl. Acad. Sci. USA. 90:4942-4946.
12. Kundig, T.M., A. Althage, H. Hengartner, and R.M. Zinkernagel. 1992. Skin test to assess virus-specific cytotoxic T-cell activity. Proc. Natl. Acad. Sci. USA. 89:7757-7761.
13. Lee, E.-O., and J.-D. Kim. 1995. Palmitoyl lysozyme-induced stabilization of PE (phosphatidylethanolamine) liposomes and their interaction with Candida albicans. J. Biochem. 117:54-58.
14. Meade, R., P.W. Arkanase, G.P. Geba, K. Nedderman, R. Jacoby, and R.D. Pasternak. 1992. Transforming growth factor β1 inhibits murine immediate and delayed type hypersensitivity. J. Immunol. 149:521-582.
15. Metzger, J., K.-H. Weismuller, R. Schaude, W.G. Bessler, and G. Jung. 1991. Synthesis of novel immunologically active tripalmitoyl-S-glycerylcysteinyl lipopeptides as useful intermediates for immunogen preparations. Int. J. Pept. Protein Res. 37:46-57.
16. Meyer, D., D.E. Anderson, M.B. Gardner, and J.V. Torres. 1998. Hypervariable epitope constructs representing variability in envelope glycoprotein of SIV induce a broad humoral immune response in rabbits and rhesus macaques. AIDS Res. Hum. Retroviruses. 14:751-760.
17. Nardelli, B., and J.P. Tam. 1993. Cellular immune responses induced by in vivo priming with a lipid-conjugated multimeric antigen peptide. Immunology. 79:355-361.
18. Nehete, P.N., R.B. Arlinghaus, and K.J. Sastry. 1994. Use of helper T cell-inducing peptides from conserved regions in HIV-1 env in a noncovalent mixture with a CTL-inducing V3-loop peptide for in vivo induction of long-lasting systemic CTL response. Viral Immunol. 7:189-197.
19. Rinaldo, C., X.-L. Huang, Z. Fan, M. Ding, L. Beltz, A. Lagar, D. Panicalli, G. Mazarra, J. Liebman, M. Cottrill, and P. Gupta. 1995. High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T cell lymphocyte activity and low viral load are associated with lack of disease in HIV-1 infected long-term progressors. J. Virol. 69:5838-5842.
20. Rock, K., S. Gamble, and L. Rothstein. 1990. Presentation of exogenous antigen with class I MHC complex molecules. Science. 249:918-921.
21. Rock, K., L. Rothstein, S. Gamble, and C. Fleischacker. 1993. Characterization of antigen-presenting cells that present exogenous antigens in association with class I MHC molecules. J. Immunol. 150:438-446.
22. Sato, Y., M. Roman, H. Tighe, D. Lee, C. Maripot, M.-D. Nguyen, G.J. Silverman, M. Lotz, D.A. Carson, and E. Raz. 1996. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science. 273:352-354.
23. Schulz, M., R.M. Zinkernagel, and H. Hegartnen. 1991. Peptide induced antiviral protection by cytotoxic T cells. Proc. Natl. Acad. Sci. USA. 88:991-993.
24. Takahashi, H., B. Takeshita, B. Morein, S. Putney, R.N. Germain, and J.A. Berzofsky. 1990. Induction of CD8+ cytotoxic T cells by incubation with purified HIV-1 envelope protein in ISCOMS. Nature. 344:873-875.
25. Taylor, P.M., and B.A. Askonas. 1986. Influenza nucleoprotein specific cytotoxic T-cell clones are protective in vivo. Immunology. 58:417-421.
26. Tori, I., S. Morakawa, T. Harada, and Y. Kitamura. 1993. Two distinct types of cellular mechanisms in the development of DTH in mice: requirement of either mast cells or macrophages for elicitation of the response. Immunology. 78:482-490.
27. Verheul, A.F.M., U. Venkatachalam, D.L. Lue, M.W. Robert, and A.A. Lal. 1995. Monopalmitic acid-peptide conjugates induce CTL responses against malarial epitopes: importance of spacer amino acids. J. Immunol. Methods. 182:219-226.
28. Weismuller, K.-H., G. Jung, and G. Hess. 1989. Novel low-molecular weight synthetic vaccine against foot and mouth disease containing a potent B-cell and macrophage activator. Vaccine. 7:29-33.
29. Weiss, W.R., M. Sedegah, R.L. Beaudoin, L.H. Miller, and M.F. Good. 1988. CD8+ T cells (cytotoxic/suppressors) are required for protection in mice immunized with malaria sporozoites. Proc. Natl. Acad. Sci. USA. 85:573-576.