Perflubron emulsion improves tolerance to low-flow ischemia in isolated rabbit hearts

Journal of Cardiovascular Pharmacology

Volumn 34, Issue 1, 1999, Pages 108-115

  Symons, J D ^a,b   Sun, X ^a   Flaim, S F ^a   Del Balzo, U ^a  

^a Alliance Pharmaceutical Corporation   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Ischemia; Ischemic contracture; Myocardial ischemia; Perflubron emulsion; Perfluorocarbon; Temporary oxygen carrier

Indexed keywords

PERFLUOROOCTYL BROMIDE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; HEART MUSCLE ISCHEMIA; HEART MUSCLE OXYGEN CONSUMPTION; HEART MUSCLE PERFUSION; HIGH ENERGY PHOSPHATE; ISOLATED HEART; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ADENOSINE DIPHOSPHATE; ADENOSINE MONOPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMALS; CORONARY VESSELS; FLUOROCARBONS; HEART; HEMODYNAMIC PROCESSES; LACTIC ACID; MYOCARDIAL ISCHEMIA; MYOCARDIUM; OXYGEN; PERFUSION; PHOSPHATES; RABBITS;

EID: 0033023299     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199907000-00018     Document Type: Article

References (31)

1. Reimer KA, Jennings RB, Tatum AH. Pathobiology of acute myocardial ischemia: metabolic, functional and ultrastructural studies. Am J Cardiol 1983;52:72A-81A.
2. van der Vusse GJ, van der Veen FH. Myocardial high-energy phosphates during open-heart surgery. In: de Jong JW, ed. Myocardial energy metabolism. Boston: Martinus Nijhoff, 1988:245-55.
3. Hearse DJ, Braimbridge MV, Jynge P, et al. Protection of the ischemic myocardium, cardioplegia. New York: Raven Press, 1981.
4. Flameng W. New strategies for intraoperative myocardial protection. Curr Opin Cardiol 1995;10:577-83.
5. Hearse DJ, O'Brien K, Braimbridge MV. Protection of the myocardium during ischemic arrest: dose-response curves for procaine and lignocaine in cardioplegic solutions. J Thorac Cardiovasc Surg 1981;81:873-9.
6. Riess JG, LeBlanc M. Solubility and transport phenomena in perfluorochemicals relevant to blood substitution and other biomedical applications. Pure Appl Chem 1982;54:2383-406.
7. Bando K, Teramoto S, Tago M, et al. Oxygenated perfluorocarbon, recombinant human superoxide dismutase, and catalase ameliorate free radical induced myocardial injury during heart preservation and transplantation. J Thorac Cardiovasc Surg 1988;96:930-8.
8. Glogar DH, Kloner RA, Muller J, et al. Fluorocarbons reduce myocardial ischemic damage after coronary occlusion. Science 1981;211:1439-41.
9. Gohra H, Mori F, Esato K. The effect of fluorocarbon emulsion on 24-hour canine heart preservation by coronary perfusion. Ann Thorac Surg 1989;48:96-103.
10. Forman MB, Bingham S, Kopelman HA, et al. Reduction of infarct size with intracoronary perfluorochemical in a canine preparation of reperfusion. Circulation 1985;71:1060-8.
11. Kanter KR, Jaffin JH, Ehrlichman RJ, et al. Superiority of perfluorocarbon cardioplegia over blood or crystalloid cardioplegia. Circulation 1981;64:II-75-80.
12. Kioka Y, Tago M, Bando K, et al. Twenty-four-hour isolated heart preservation by perfusion method with oxygenated solution containing perfluorochemicals and albumin. J Heart Transplant 1986; 5:437-43.
13. Rice HE, Virmani R, Hart CL, Kolodgie FD, Farb A. Dose-dependent reduction of myocardial infarct size with the perfluorochemical Fluosol-DA. Am Heart J 1990;120:1039-46.
14. Segel LD, Minten JM, Schweighardt FK. Fluorochemical emulsion APE-LM substantially improves cardiac preservation. Am J Physiol 1992;263:H730-9.
15. Segel LD, Rendig SV. Isolated working rat heart perfusion with perfluorochemical emulsion Fluosol-43. Am J Physiol 1982;242: H485-9.
16. Stocchi V, Cucchiarini L, Magnani M, et al. Simultaneous extraction and reverse-phase high-performance liquid chromatographic determination of adenine and pyridine nucleotides in human red blood cells. Anal Biochem 1985;146:118-24.
17. Wall TC, Califf RM, Blankenship J, et al. Intravenous Fluosol in the treatment of acute myocardial infarction: results of the Thrombolysis and Angioplasty in Myocardial Infarction 9 Trial. Circulation 1994;90:114-20.
18. Forman MB, Perry JM, Wilson BH, et al. Demonstration of myocardial reperfusion injury in humans: results of a pilot study utilizing acute coronary angioplasty with perfluorochemical in anterior myocardial infarction. J Am Coll Cardiol 1991;18:911-8.
19. Henry PD, Schuchleib R, Davis J, Weiss ES, Sobel BE. Myocardial contracture and accumulation of mitochondrial calcium in ischemic rabbit heart. Am J Physiol 1977;233:H677-84.
20. Tomlinson CW, Toleikis PM. Myocardial protection during ischemia in the isolated perfused rabbit heart. Can J Cardiol 1987;3: 136-43.
21. Dixon M. Manometric methods: as applied to the measurement of cell respiration and other processes. 3rd ed. Cambridge: Cambridge University Press, 1951.
22. Kammermeier H. Meaning of energetic parameters. Basic Res Cardiol 1993;88:380-4.
23. Bergmeyer HA. Methods of enzymatic analysis. 3rd ed. Weinheim, Germany: VCH Publishers, 1989:343.
24. Ely SW, Mentzer RM Jr, Lasley RD, Lee BK, Berne RM. Functional and metabolic evidence of enhanced myocardial tolerance to ischemia and reperfusion with adenosine. J Thorac Cardiovasc Surg 1985;90:549-56.
25. Tabayashi K, McKeown PP, Miyamoto M, et al. Ischemic myocardial protection: comparison of nonoxygenated crystalloid, oxygenated crystalloid, and oxygenated fluorocarbon cardioplegic solutions. J Thorac Cardiovasc Surg 1988;95:239-46.
26. Depre C, Vanoverschelde JL, Goudemant JF, Mottet I, Hue L. Protection against ischemic injury by nonvasoactive concentrations of nitric oxide synthase inhibitors in the perfused rabbit heart. Circulation 1995;92:1911-8.
27. Katz AM, Tada M. The "stone heart": a challenge to the biochemist. Am J Cardiol 1972;29:578-80.
28. Ventura-Clapier R, Veksler V. Myocardial ischemic contracture: metabolites affect rigor tension development and stiffness. Circ Res 1994;74:920-9.
29. Ventura-Clapier R, Vassort G. Rigor tension during metabolic and ionic rises in resting tension in rat heart. J Mol Cell Cardiol 1981; 13:551-61.
30. i; elevation and ATP depletion. Am J Physiol 1990;258:H9-16.
31. Schaefer S, Prussel E, Carr LJ. Requirement of glycolytic substrate for metabolic recovery during moderate low flow ischemia. J Mol Cell Cardiol 1995;27:2167-76.