Immunohistochemical investigation of p53 and EGFR expression of oligodendrogliomas

Clinical Neuropathology

Volumn 18, Issue 4, 1999, Pages 176-180

  Broholm, H ^a,b   Bols, B ^a   Heegaard, S ^a,b   Braendstrup O ^a  

^a GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

EGFR; Immunohistochemistry; Oligodendroglioma; P53; Prognosis

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN P53;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CLINICAL ARTICLE; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; OLIGODENDROGLIOMA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SCORING SYSTEM; TISSUE DISTRIBUTION;

ADOLESCENT; ADULT; AGE FACTORS; AGED; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; OLIGODENDROGLIOMA; PROGNOSIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SUPRATENTORIAL NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033022961     PISSN: 07225091     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Barbareschi M, Leonardi E, Mauri FA, Serio G, Palma PD 1992 p53 and c-erbB-2 protein expression in breast carcinomas. Am J Clin Pathol 98: 408-418
2. Barker FG, Israel MA 1995 The molecular biology of brain tumors. Neurol Clin 13: 701-721
3. Bögler O, Huang H-JS, Kleihues P, Cavenee W K 1995 The p53 gene and its role in human brain tumors. Glia 15: 308-327
4. Bruner JM, Saya H, Moser RP 1991 Immunocytochemical detection of p53 in human gliomas. Mod Pathol 4: 671-674
5. Bruner JM, Langford LA, Fuller GN 1993 Neuropathology, cell biology, and newer diagnostic methods. Curr Opin Oncol 5: 441-449
6. Carson DA 1995 Cancer progression and p53. Lancet 346: 1009-1011
7. Chozick BS, Pezzullo JC, Epstein MH, Finch PW 1994 Prognostic implications of p53 overexpression in supratentorial astrocytic tumors. Neurosurg 35: 831-838
8. Chung R, Whaley J, Kiev N, Anderson K, Louis D, Menon A, Hettlich C, Freiman R, Hedley-Whyte ET, Martuza R, Jenkins R, Yandell D, Seizinger BR 1991 TP53 Gene mutations and 17p deletions in human astrocytomas. Genes Chrom Cancer 3: 323-331
9. Dorward NL, Hawkins RA, Whittle IR 1993 Epidermal growth factor receptor activity and clinical outcome in glioblastoma and meningioma. Br J Neurosurg 7: 197-200
10. Hagel C, Laking G, Laas R, Scheil S, Jung R, Milde-Langosch K, Stavrou DK 1996 Demonstration of p53 protein and TP53 gene mutations in oligodendrogliomas. Eur J Cancer 32: 2242-2248
11. Heegaard S, Sommer HM, Broholm H, Brændstrup O 1995 Proliferating cell nuclear antigen and Ki-67 immunohistochemistry of oligodendrogliomas with special reference to prognosis. Cancer 76: 1809-1813
12. Hsieh L-L, Hsia C-F, Wang L-Y, Chen C-J, Ho Y-S 1994 p53 gene mutations in brain tumors in Taiwan. Cancer Lett 78: 25-32
13. Jaros E, Perry RH, Adam L, Kelly PJ, Crawford PJ, Kalbag RM, Mendelow AD, Sengupta RP, Pearson ADJ 1992 Prognostic implications of p53 protein, epidermal growth factor receptor, and Ki-67 labelling in brain tumours. Br J Cancer 66: 373-385
14. Karamitopoulou E, Perentes E, Diamantis I 1993 p53 protein expression in central nervous system tumors: an immunohistochemical study with CM1 polyvalent and DO-7 monoclonal antibodies. Acta Neuropathol 85: 611-616
15. Kleihues P, Burger PC, Scheithauer BW 1993 Histological Typing of Tumours of the Central Nervous System (2nd Ed). World Health Organization, Geneva
16. Korkolopoulou P, Christodoulou P, Kouzelis K, Hadjiyannakis M, Priftis A, Stamoulis G, Seretis A, Thomas-Tsagli E 1997 MDM2 and p53 expression in gliomas: a multivariate survival analysis including proliferation markers and epidermal growth factor receptor. Br J Cancer 75: 1269-1278
17. Kros JM, Troost D, van Eden CG, van der Werf AJM, Uylings HBM 1988 Oligodendroglioma: a comparison of two grading systems. Cancer 61: 2251-2259
18. Kros JM, Godschalk JJCJ, Krishnadath KK, van Eden CG 1993 Expression of p53 in oligodendrogliomas. J Pathol 171: 285-290
19. Kros JM, Hop WCJ, Godschalk JJCJ, Krishnadath KK 1996 Prognostic value of the proliferation-related antigen Ki-67 in oligodendrogliomas. Cancer 78: 1107-1113
20. Kyritsis AP, Saya H 1993 Epidemiology, cytogenetics, and molecular biology of brain tumors. Curr Opin Oncol 5: 474-480
21. Lang FF, Miller DC, Pisharody S, Koslow M, Newcomb EW 1994 High frequency of p53 protein accumulation without p53 gene mutation in human juvenile pilocytic, low grade and anaplastic astrocytomas. Oncogene 9: 949-954
22. Litofsky NS, Hinton D, Raffel C 1994 The lack of a role for p53 in astrocytomas in pediatric patients. Neurosurg 34: 967-973
23. Louis DN 1994 The p53 gene and protein in human brain tumors. J Neuropathol Exp Neurol 53: 11-21
24. Ohgaki H, Eibl RH, Wiestler OD, Yasargil MG, Newcomb EW, Kleihues P 1991 p53 mutations in nonastrocytic human brain tumors. Cancer Res 51: 6202-6205
25. Ohgaki H, Eibl RH, Schwab M, Reichel MB, Mariani L, Gehring M, Petersen I, Höll T, Wiestler OD, Kleihues P 1993 Mutations of the p53 tumor suppressor gene in neoplasms of the human nervous system. Mol Carcinog 8: 74-80
26. Pavelic J, Hlavka V, Poljak M, Gale N, Pavelic K 1994 p53 immunoreactivity in oligodendrogliomas. J Neurooncol 22: 1-6
27. Peterson K, Cairncross JG 1995 Oligodendrogliomas. Neurol Clin 13: 861-873
28. Rasheed BKA, McLendon RE, Herndon JE, Friedman HS, Friedman AH, Bigner DD, Bigner SH 1994 Alterations of the TP53 gene in human gliomas. Cancer Res 54: 1324-1330
29. Reifenberger J, Reifenberger G, Liu L, James CD, Wechsler W, Collins VP 1994 Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p. Am J Pathol 145: 1175-1190
30. Russell DS, Rubinstein LJ 1989 Pathology of Tumours of the Nervous System (5th Ed). Arnold, London, pp 172-187
31. Smith MT, Ludwig CL, Godfrey AD, Armbrustmacher VW 1983 Grading of oligodendrogliomas. Cancer 52: 2107-2114
32. Soini Y, Niemelä A, Kamel D, Herva R, Bloigu R, Pääkkö P, Vähäkangas K 1994 p53 immunohistochemical positivity as a prognostic marker in intracranial tumours. APMIS 102: 786-792
33. Torp SH, Helseth E, Dalen A, Unsgaard G 1992 Relationships between Ki-67 labelling index, amplification of the epidermal growth factor receptor gene, and prognosis in human glioblastomas. Acta Neurochir (Wien) 117: 182-186