Double-blind, randomized study of nalmefene and naloxone in emergency department patients with suspected narcotic overdose

Annals of Emergency Medicine

Volumn 34, Issue 1, 1999, Pages 42-50

  Kaplan, J L ^a   Marx, J A ^a   Calabro, J J ^a   Gin Shaw, S L ^a   Spiller, J D ^a   Spivey, W L ^a   Gaddis, G M ^a   Zhao, N ^a   Harchelroad F P , Jr ^a  

^a ALBERT EINSTEIN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NALMEFENE; NALOXONE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG OVERDOSE; DRUG SAFETY; DRUG WITHDRAWAL; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; NARCOTIC DEPENDENCE; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; TREATMENT OUTCOME; WITHDRAWAL SYNDROME;

EID: 0033022631     PISSN: 01960644     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-0644(99)70270-2     Document Type: Article

References (12)

1. SH Ngai BA Berkowitz JC Yang Pharmacokinetics of naloxone in rats and man: Basis for its potency and short duration of action Anesthesiology 44 1976 398 401
2. JM Evans MIJ Hogg JN Lunn Degree and duration of reversal by naloxone of effects of morphine in conscious subjects BMJ 2 1974 589 591
3. MJ Ellenhom DG Barceloux Medical Toxicology. Diagnosis and Treatment of Human Poisoning 1988 : Elsevier New York 692 711
4. EF Hahn J Fishman RD Heilman Narcotic antagonists: 4. Carbon-6 derivatives of n-substituted noroxymorphones as narcotic antagonists J Med Chem 18 1975 259 262
5. R Dixon J Howes J Gentile Nalmefene: Intravenous safety and kinetics of a new opioid antagonist Clin Pharm Ther 39 1986 49 53
6. TJ Gal CA Difazio Prolonged antagonism of opioid action with intravenous nalmefene in man Anesthesiology 64 1986 175 180
7. JL Kaplan JA Marx Effectiveness and safety of intravenous nalmefene for emergency department patients with suspected narcotic overdose: A pilot study Ann Emerg Med 22 1993 187 190
8. Integrated Safety Data Summary Regarding Nalmefene [final report to the Food and Drug Administration] April 1995 : Ohmeda Inc Liberty Corner, NJ
9. DA Chernik M Tucker B Gigli Validity and reliability of the Neurobehavioral Assessment Scale J Clin Psychopharmacol 12 1992 43 48
10. DA Smith L Leake JR Loflin Is admission after intravenous heroin overdose necessary? Ann Emerg Med 21 1992 1326 1330
11. WG Barsan D Seger DF Danzl Duration of antagonistic effects of nalmefene and naloxone in opiate-induced sedation for emergency department procedures Am J Emerg Med 7 1989 155 161
12. PSA Glass RM Jhaveri LR Smith Comparison of potency and duration of action of nalmefene and naloxone Anesth Analg 78 1994 536 541