Dose-dependence of bacterial lipopolysaccharide (LPS) effects on peak response and time course of the immune-endocrine host response in humans

Inflammation Research

Volumn 48, Issue 2, 1999, Pages 67-74

  Vedder, H ^a,c   Schreiber, W ^a   Yassouridis, A ^a   Gudewill, S ^a   Galanos, C ^b   Pollmacher T ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Cortisol; Cytokines; Hormones; Lipopolysaccharide; Neuro immune endocrine network

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CORTICOTROPIN; HUMAN GROWTH HORMONE; HYDROCORTISONE; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; DOSE RESPONSE; DOSE TIME EFFECT RELATION; GROWTH HORMONE BLOOD LEVEL; HEART RATE; HORMONE RELEASE; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; IMMUNE RESPONSE; LEUKOCYTE COUNT; MALE; NORMAL HUMAN;

ADRENOCORTICOTROPIC HORMONE; ADULT; BODY TEMPERATURE; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART RATE; HORMONES; HUMAN GROWTH HORMONE; HUMANS; HYDROCORTISONE; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MALE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033022555     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000110050408     Document Type: Article

References (39)

1. Besedovsky HO, del Rey A. Immune-neuroendocrine circuits: integrative role of cytokines. Front Neuroendocrinol 1992;13: 61-94.
2. Spangelo BL, Gorospe WC. Role of the cytokines in the neuroendocrine-immune system axis. Front Neuroendocrinol 1995;16:1-22.
3. Ader R, Cohen N, Felten D. Psychoneuroimmunology: interactions between the nervous system and the immune system. Lancet 1995;345:99-103.
4. Beutler B, Kruys V. Lipopolysaccharide signal transduction, regulation of tumor necrosis factor biosynthesis, and signaling by tumor necrosis factor itself. J Cardiovasc Pharmacol 1995;25:S1-8.
5. Coley WB. The treatment of inoperable malignant tumors with the toxins of erysipelas and the bacillus prodigiosus. Am J Med Sci 1894;108:50-68.
6. Carswell EA, Old LJ, Kassel RL, Carswell EA, Old LJ, Kassel RL, et al. An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci USA 1975;72:3666-70.
7. Hirano T. Interleukin 6 and its receptor: ten years later. Int Rev Immunol 1998;16:249-84.
8. Michie HR, Monogue KR, Spriggs DR, Revhaug A, O'Dwyer S, Dinarello CA, et al. Detection of circulating tumor necrosis factor after endotoxin administration. N Engl J Med 1988;318:1481-6.
9. Pollmächer T, Schreiber W, Gudewill S, Vedder H, Fassbender K, Wiedemann K, et al. Influence of endotoxin on nocturnal sleep in humans. Am J Physiol 1993;264:R1077-83.
10. Suffredini AF, Reda D, Banks SM, Tropea M, Agosti JM, Miller R. Effects of recombinant dimeric TNF receptor on human inflammatory responses following intravenous endotoxin administration. J Immunol 1995;155:5038-45.
11. Burrell R. Human responses to bacterial endotoxin. Circ Shock 1994;43:137-53.
12. Spriggs DR, Sheram ML, Frei E III, Kufe DW. Clinical studies with tumor necrosis factor. In: Bock G, Marsh J, editors. Tumor necrosis factor and related cytokins, Ciba Foundation Symposium 131. Chichester: John Wiley & Sons Ltd., 1987:206-19.
13. Suffredini AF. Current prospects for the treatment of clinical sepsis. Crit Care Med 1994;22:S12-8.
14. Dinarello CA. Interleukin-1. Cytokine Growth Factor Rev 1997;8: 253-65.
15. Woloski BM, Smith EM, Meyer WJ 3rd, Fuller GM, Blalock JE. Corticotropin-releasing activity of monokines. Science 1985;230: 1035-7.
16. Besedovsky H, del Rey A, Sorkin E, Dinarello CA. Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science 1986;233:652-4.
17. Eskay RL, Grino M, Chen HT. Interleukins, signal transduction, and the immune system-mediated stress response. Adv Exp Med Biol 1990;274:331-43.
18. Naitoh Y, Fukata J, Tominaga T, Nakai Y, Tamai S, Mori K, et al. Interleukin-6 stimulates the secretion of adrenocorticotropic hormone in conscious, freely-moving rats. Biochem Biophys Res Commun 1988;155:1459-63.
19. Revhaug A, Michie HR, Manson JM, Watters JM, Dinarello CA, Wolff SM, et al. Inhibition of cyclo-oxygenase attenuates the metabolic response to endotoxin in humans. Arch Surg 1988;123: 162-70.
20. Zabel P, Wolter DT, Schönharting MM, Schade UF. Oxypentifylline in endotoxaemia. Lancet 1989;2:1474-7.
21. Hochstein HD, Fitzgerald EA, McMahon FG, Vargas R. Properties of US standard endotoxin (EC-5) in human male volunteers. J Endotox Res 1994;1:52-6.
22. Elin RJ, Wolff SM, McAdam KPWJ, Chedid L, Audihert C, Bernhard C, et al. Properties of reference Escherichia coli endotoxin and its phthalylated derivative in humans. J Infect Dis 1981;44:329-333.
23. Gudewill S, Pollmächer T, Vedder H, Schreiber W, Fassbender K, Holsboer F. Nocturnal plasma levels of cytokines in healthy men. Eur Arch Psychiatry Clin Neurosci 1992;242: 53-6.
24. Galanos C, Lüderitz O, Westphal O. Preparation and properties of standardized lipopolysaccharide from salmonella abortus equi (Novo-Pyrexal). Zentralbl Bakteriol (Orig A) 1979;243:226-44.
25. DeGroote D, Grau GE, Dehart I, Franchimont P. Stabilisation of functional tumor necrosis factor-α by its soluble TNF-receptors. Eur Cytokine Netw 1993;4:359-62.
26. Engelhardt R, Mackensen A, Galanos C, Andreesen R. Biological response to intravenously administered endotoxin in patients with advanced cancer. J Biol Response Mod 1990;9:480-91.
27. Simpson AE, Tomkins PT, Cooper KL. An investigation of the temporal induction of cytokine mRNAs in LPS-challenged thioglycollate-elicited murine peritoneal macrophages using the reverse trasnscripotin polymerase chain reaction. Inflamm Res 1997;46:65-71.
28. Barber AE, Coyle SM, Marano MA, Fischer E, Calvano SE, Fong Y, et al. Glucocorticoid therapy alters hormonal and cytokine responses to endotoxin in man. J Immunol 1993; 150:1999-2006.
29. Brouckaert P, Spriggs DR, Demetri G, Kufe DW, Fiers W. Circulating interleukin 6 during a continuous infusion of tumor necrosis factor and interferon gamma. J Exp Med 1989;169:2257-62.
30. Jablons DM, Mule JJ, McIntosh JK, Sehgal PB, May LT, Huang CM, et al. IL-6/IFN-beta-2 as a circulating hormone. Induction by cytokine administration in humans. J Immunol 1989;142:1542-7.
31. Michie HR, Majzoub JA, O'Dwyer ST, Revhaug A, Wilmore DW. Both cyclooxygenase-dependent and cyclooxygenase-independent pathways mediate the neuroendocrine response in humans. Surgery 1990;108:254-61.
32. Schreiber W, Pollmächer T, Fassbender K, Gudewill S, Vedder H, Wiedemann K, et al. Endotoxin- and corticotropin-releasing hormone-induced release of ACTH and cortisol. A comparative study in men. Neuroendocrinology 1993;58:123-8.
33. von Bardeleben U, Holsboer F. Human corticotropin releasing hormone: clinical studies in patients with affective disorders, alcoholism, panic disorder and in normal controls. Prog Neuropsychopharmacol Biol Psychiatry 1988;12 Suppl: S165-87.
34. Darling G, Goldstein DS, Stull R, Gorschboth CM, Norton JA. Tumor necrosis factor: immune endocrine interaction. Surgery 1989;106:1155-60.
35. Bernardini R, Kamilaris TC, Calogero AE, Johnson EO, Gomes MT, Gold PW, et al. Interactions between tumor necrosis factor-alpha, hypothalamic corticotropin-releasing hormone, and adrenocorticotropin secretion in the rat. Endocrinology 1990;126:2876-81
36. Salas MA, Evans SW, Levell MJ, Whicher JT. Interleukin-6 and ACTH act synergistically to stimulate the release of corticosterone from adrenal gland cells. Clin Exp Immunol 1990;79:470-3.
37. Van Cauter E, Plat L. Physiology of growth hormone secretion during sleep. J Pediatr 1996;128:S32-7.
38. Spangelo BL, Judd AM, Call GB, Zumwalt J, Gorospe WC. Role of the cytokines in the hypothalamic-pituitary-adrenal and gonadal axes. Neuroimmunomodulation 1995;2:299-312.
39. Rivier C, Vale W. Corticotropin-releasing factor (CRF) acts centrally to inhibit growth hormone secretion in the rat. Endocrinology 1984;114:2409-11.