Isolation, characterization and disruption of the areA nitrogen regulatory gene of Gibberella fujikuroi

Molecular and General Genetics

Volumn 261, Issue 1, 1999, Pages 106-114

  Tudzynski, B ^a   Homann, V ^a   Feng, B ^b   Marzluf, G A ^b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

areA gene; Gibberella fujikuroi; Gibberellin biosynthesis; Nitrogen regulation

Indexed keywords

AMINO ACID; AMMONIA; DNA BINDING PROTEIN; FUNGAL PROTEIN; GIBBERELLIN; GLUTAMINE; HYGROMYCIN B; MUTANT PROTEIN; NITRATE; NITRATE REDUCTASE; NITROGEN; PHOSPHOTRANSFERASE; ZINC FINGER PROTEIN;

AGRICULTURE; AMINO ACID SEQUENCE; ARTICLE; CLONE; CODON; CONTROLLED STUDY; EXPRESSION VECTOR; GENE CASSETTE; GENE TRANSFER; GENETIC COMPLEMENTATION; GENETIC TRANSFORMATION; GIBBERELLA FUJIKUROI; NEUROSPORA CRASSA; NITROGEN METABOLISM; NONHUMAN; PRIORITY JOURNAL; REGULATOR GENE; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; CLONING, MOLECULAR; DNA, FUNGAL; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENE TARGETING; GENES, FUNGAL; GENETIC COMPLEMENTATION TEST; GIBBERELLA; GIBBERELLINS; MOLECULAR SEQUENCE DATA; MUTATION; NEUROSPORA CRASSA; NITRATE REDUCTASE; NITRATE REDUCTASES; NITROGEN; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS;

EID: 0033021664     PISSN: 00268925     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004380050947     Document Type: Article

References (54)

1. Avalos J, Mackenzie A, Nelki DS, Bramley PM (1988) Terpenoid biosynthesis in cell extracts of wild type and mutant strains of Gibberella fujikuroi. Biochim Biophys Acta 966:257-265
2. Ballario P, Vittorioso P, Magrelli A, Talora C, Cabibbo A, Macino G (1996) White collar-1, a central regulatory gene of blue light responses in Neurospora crassa. EMBO J 15:1650-1657
3. Barendse GWM, van de Werken PH, Takahashi N (1980) High-performance liquid chromatography of gibberellins. J Chrom 198:449-455
4. Bearder JPR (1983) In vitro diterpenoid biosynthesis in Gibberella fujikuroi. The pathway after ent-kaurene. In: Crozier A (ed) The biochemistry and physiology of gibberellin, vol. 1. Praeger, New York, pp 251-387
5. Borrow A, Jefferys EG, Kessell RHJ, Lloyd EC, Lloyd PB, Nixon IS (1961) The metabolism of Gibberella fujikuroi in stirred culture. Can J Microbiol 7:227-276
6. Borrow A, Brown EG, Jefferys EG, Kessell RHJ, Lloyd EC, Lloyd PB, Rothwell A, Rothwell B, Swait JC (1964) The kinetics of metabolism of Gibberella fujikuroi in stirred culture. Can J Microbiol 10:407-444
7. Brückner B, Blechschmidt D (1991a) The gibberellin fermentation. Crit Rev Biotechnol 11:1163-1192
8. Brückner B, Blechschmidt D (1991b) Nitrogen regulation of gibberellins in Gibberella fujikuroi. Appl Microbiol Biotechnol 53:646-650
9. Brückner B, Blechschmidt D, Sembdner G, Schneider G (1989) Fungal gibberellin production. In: Vandamme EJ (ed) Biotechnology of vitamins, pigments and growth factors. Elsevier, New York, pp 383-429
10. Bu'Lock J, Detroy R, Hostalek Z, Munin-al-Shakardu A (1974) Regulation of secondary biosynthesis in Gibberella fujikuroi. Trans Brit Mycol Soc 62:377-389
11. Caddick MX (1992) Characterization of a major Aspergillus regulatory gene: areA. In: Stahl U, Tudzynski P (eds) Molecular biology of filamentous fungi. VCH Press, Weinheim, pp 141-152
12. Caddick MX, Peters D, Platt A (1994) Nitrogen regulation in fungi. Antonie von Leeuwenhoek 65:169-177
13. Candau R, Avalos J, Cerdá-Olmedo E (1992) Regulation of gibberellin biosynthesis in Gibberella fujikuroi. Plant Physiol 100:1184-1188
14. Cenis JL (1993) Rapid extraction of fungal DNA for PCR amplification. Nucleic Acids Res 20:2380
15. Chambers AA, Russo VEA (1986) Isolating RNA is easy and fun. Fungal Genet Newslett 33:22-23
16. Cherniack AD, Garriga G, Kittle JD, Lambowitz AM (1990) Function of Neurospora mitochondrial tyrosyl tRNA-synthetase in RNA splicing requires an idiosyncratic domain not found in other synthetases. Cell 62:745-755
17. Cooper TG (1996) Regulation of allantoin catabolism in Saccharomyces cerevisiae. In: Brambl R, Marzluf GA (eds) The Mycota III. Biochemistry and molecular biology. Springer-Verlag, Berlin, pp 139-169
18. Darken MA, Jensen AL, Shu P (1959) Production of gibberellic acid by fermentation. Appl Microbiol 7:301-303
19. Desjardins AE, Gardner HW, Weltring KM (1992) Detoxification of sesquiterpene phytoalexins by Gibberella pulicaris (Fusarium sambucinum) and its importance for virulence on potato tubers. J Indust Microbiol 9:201-211
20. Dickmann MB, Leslie JF (1992) The regulatory gene nit-2 of Neurospora crassa complements a nnu mutant of Gibberella zeae (Fusarium graminearum). Mol Gen Genet 235:458-462
21. Doyle JJ, Doyle JL (1990) Isolation of plant DNA from fresh tissue. Focus 12:13-15
22. Feng B, Ffiedlin E, Marzluf GA (1995) Nuclear DNA-binding proteins which recognize the intergenic control region of penicillin biosynthetic genes. Curr Genet 27:351-358
23. Froeliger EH, Carpenter BE (1996) NUT1, a major nitrogen regulatory gene in Magnaporthe grisea, is dispensable for pathogenicity. Mol Gen Genet 251:647-656
24. Fu Y-H, Marzluf GA (1987) Characterization of nit-2, the major nitrogen regulatory gene of Neurospora crassa. Mol Cell Biol 7:1691-1696
25. Fu Y-H, Marzluf GA (1990a) nit-2, the major nitrogen regulatory gene of Neurospora crassa, encodes a protein with a putative zinc finger DNA-binding domain. Mol Cell Biol 10:1056-1065
26. Fu Y-H, Marzluf GA (1990b) nit-2, the major positive-acting nitrogen regulatory gene of Neurospora crassa, encodes a sequence-specific DNA-binding protein. Proc Natl Acad Sci USA 87:5331-5335
27. Garnett RH, Cove EJ (1967) Formation of NADP-nitrate reductase activity in vitro from Aspergillus nidulans niaD and cnx mutants. Mol Gen Genet 149:179-186
28. Gurr SJ, Unkles SE, Kinghorn JR (1987) The structure and organization of nuclear genes in filamentous fungi. In: Kinghorn JR (ed) Gene structure in eucaryotic microbes. Oxford, IRL Press, pp 93-139
29. Haas H, Marzluf GA (1995) NRE, the major nitrogen regulatory protein of Penicillium chrysogenum, binds specifically to elements in the intergenic promoter regions of nitrate assimilation and penicillin biosynthetic gene clusters. Curr Genet 28:177-183
30. Hass H, Bauer B, Redl B, Stöffler G, Marzluf GA (1995) Molecular cloning and analysis of nre, the major nitrogen regulatory gene of Penicillium chrysogenum. Curr Genet 27:150-158
31. Haas H, Angermayr K, Zadra I, Stöffler G (1997) Overexpression of nreB, a new GATA factor-encoding gene of Penicillium chrysogenum, leads to repression of the nitrate assimilatory gene cluster. J Biol Chem 272:22576-22582
32. Homann V, Mende K, Arntz C, Ilardi V, Macino G, Morelli G, Böse G, Tudzynski B (1996) The isoprenoid pathway: cloning and characterization of fungal FPPS genes. Curr Genet 30:232-239
33. Kudla B, Caddick MX, Langdon T, Martinez-Rossi NM, Bennett CF, Sibley S, Davies RW (1990) The regulatory gene areA mediating nitrogen metabolite repression in Aspergillus nidulans. Mutations affecting specificity of gene activation alter a loop residue of a putative zinc finger. EMBO J 9:1355-1364
34. Langdon T, Sheerins A, Ravagnani A, Gielkens M, Caddick MX, Arst HN Jr (1995) Mutational analysis reveals dispensability of the N-terminal region of the Aspergillus transcription factor mediating nitrogen metabolite repression. Mol Microbiol 17:877-888
35. Lau GW, Hamer JE (1998) Acropetal: a genetic locus required for conidiophore architecture and pathogenicity in the rice blast fungus. Fungal Genet Biol 24:228-239
36. Linden H, Macino G (1997) White collar 2, a partner in blue light signal transduction, controlling expression of light-regulated genes in Neurospora crassa. EMBO J 16:98-109
37. Marzluf GA (1993) Regulation of sulfur and nitrogen metabolism in filamentous fungi. Annu Rev Microbiol 47:31-55
38. Marzluf GA (1996) Regulation of nitrogen metabolism in mycelial fungi. In: Brambl R, Marzluf GA (eds) The Mycota III. Biochemistry and molecular biology. Springer Verlag, Berlin, pp 357-368
39. Mende K, Homann V, Tudzynski B (1997) The geranylgeranyl diphosphate synthase gene of Gibberella fujikuroi: isolation and expression. Mol Gen Genet 255:96-105
40. Munoz GA, Agosin E (1993) Glutamine involvement in nitrogen control of gibberellic acid production in Giberella fujikuroi. Appl Environ Microbiol 59:4317-4322
41. Nes WD, Hanners PK, Parish EJ (1986) Control of the fungal sterol C-24 transalkylation: importance to developmental regulation. Biochem Biophys Res Commun 139:410-415
42. Peňalva MA, Perez-Esteban AB, Gomez-Pardo E, Orejas M, Espeso E (1991) Penicillin production by Aspergillus nidulans: studies on the regulation of expression of IPNS gene. In: Stahl U, Tudzynski P (eds) Molecular biology of filamentous fungi. VCH Publishers, Weinheim pp 217-227
43. Pontecorvo GV, Poper JA, Hemmons LM, McDonald KD, Buften AW (1953): The genetics of Aspergillus nidulans. Adv Genet 5:141-238
44. Rybakov YA, Bourd GI (1991) Nitrogen regulation of gibberellin biosynthesis enzyme complex in Fusarium moniliforme. J Biotechnol 21:219-228
45. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual (2nd edn). Cold Spring Harbor, Cold Spring Harbor Laboratory, N.Y.
46. Selker EU, Garrett PW (1988) DNA sequence duplications trigger gene inactivation in Neurospora crassa. Proc Natl Acad Sci USA 85:6870-6874
47. Stankovich M, Platt A, Caddick MX, Langdon T, Shaffer PM, Arst HN (1993) C-terminal truncation of the transcriptional activator encoded by areA in Aspergillus nidulans results in both loss-of-function and gain-of-function phenotypes. Mol Microbiol 7:81-87
48. Talbot NJ, Ebbole DJ, Hamer JE (1993) Identification and characterization of MPGI, a gene involved in pathogenicity from the rice blast fungus Magnaporthe grisea. Plant cell 5:1575-1590
49. Tudzynski B, Hölter K (1998) The gibberellin biosynthetic pathway in Gibberella fujikuroi: evidence for a gene cluster. Fungal Genet Biol, in press
50. Tudzynski B, Mende K, Weltring K-M, Kinghorn JR, Unkles SE (1996) The Gibberella fujikuroi niaD gene encoding nitrate reductase: isolation, sequence, homologous transformation and electrophoretic karyotype location. Microbiology 142:533-539
51. Tudzynski B, Kawaide H, Kamiya Y (1998) The gibberellin biosynthesis in Gibberella fujikuroi: cloning and characterization of the copalyl diphosphate synthase gene. Curr Genet 34:234-240
52. 9 in the tomato pathogen Cladosporium fulvum. Mon Gen Genet 243:277-285
53. Wiame JM, Grenson M, Arst HN Jr (1985) Nitrogen catabolite repression in yeasts and filamentous fungi. Adv Microbiol Physiol 26:1-87
54. Woitek S, Unkles SE, Kinghorn JR, Tudzynski B (1997) 3-Hydroxy-3-methylglutaryl-CoA reductase gene of Gibberella fujikuroi: isolation and characterization. Curr Genet 31:38-47