Effect of protein kinase C and phospholipase A2 inhibitors on the impaired ability of human diabetic platelets to cause vasodilation

British Journal of Pharmacology

Volumn 127, Issue 4, 1999, Pages 903-908

  Oskarsson, Helgi J ^a,b   Hofmeyer, Timothy G ^a   Coppey, Lawrence ^a   Yorek, Mark A ^a  

^a UNIVERSITY OF IOWA   (United States)

^b Pediatric Nurse Practitioner   (United States)

Author keywords

Diabetes; Glucose; Platelet; Signal transduction; Vasodilation

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; CALPHOSTIN C; DIACYLGLYCEROL; FRUCTOSE; GLUCOSE; GLYCEROL 2 ACETATE 1 OLEATE; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; SORBINIL; SORBITOL; TOLRESTAT;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; HYPERGLYCEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SIGNAL TRANSDUCTION; THROMBOCYTE FUNCTION; VASCULAR ENDOTHELIUM; VASODILATATION;

ADOLESCENT; ADULT; AGED; ANIMALS; BLOOD PLATELETS; DIABETES MELLITUS; DIGLYCERIDES; FEMALE; GLUCOSE; HUMANS; MALE; MIDDLE AGED; NAPHTHALENES; PHOSPHOLIPASES A; PROTEIN KINASE C; RABBITS; SORBITOL; TERPENES; VASODILATION;

EID: 0033021430     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702617     Document Type: Article

References (29)

1. AYO, S.H., RADNIK, R., GARONI, J.A., TROYER, D.A. & KREISBERG, J.I. (1991). High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures. Am. J. Physiol., 1, F571-F577.
2. CATALANO, D.G., AVERNA, M., NOTARBARTOLO, A., STRANO, A., CIABATTONI, G. & PATRONO, C. (1990), Thromboxane biosynthesis and platelet function in type II diabetes mellitus. N. Engl. J. Med., 322, 1769-1774.
3. COHEN, M. (1986). Aldose reductase, glomerular metabolism, and diabetic nephropathy. Metabolism, 35 (suppl I): 55-59.
4. CRAVEN, P.A., DAVIDSON, C.M. & DERUBERTIS, F.R. (1990). Increase in diacylglycerol mass in isolated glomeruli by glucose from de novo synthesis of glycerolipids. Diabetes, 39, 667-674.
5. CRAVEN, P.A. & DERUBERTIS, F.R. (1990). Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. J. Clin. Invest., 83, 1667-1675.
6. CRAVEN, P.A., PATTERSON, C.M. & DERUBERTIS, F.R. (1988). Role of enhanced arachidonate availability through phospholipase A2 pathway in metabolism of increased prostaglandin synthesis by glomeruli from diabetic rats. Diabetes, 37, 429-435.
7. FÖSTERMANN, U., MÜGGE, A., BODE, S.M. & FRÖLICH, J.C. (1988). Response of human coronary arteries to aggregating platelets: Importance of endothelium-derived relaxing factor and prostanoids. Circ. Res., 63, 306-312.
8. GO, M., SEKIGUCHI, K., NOMURA, H., KIKAWA, N. & NISHISUKA, Y. (1987). Further studies on the specificity of diacylgycerol for protein kinase C activation. Biochem. Biophys. Res. Commun., 144, 598-605.
9. GREENE, D.A., LATTIMER, S.A. & SIMA, A.A.D. (1987). Sorbitol, phospho-inositides and sodium-potasium-ATPase in the pathogenesis of diabetic complications. N. Engl. J. Med., 316, 599-606.
10. HAWTHORNE, G.C., BARTLETT, K., HETHERINGTON, C.S. & ALDERTI, K.G.M.M. (1989). The effect of high glucose on polyol pathway activity and myo-inositol metabolism in cultured human endothelial cells. Diabetologia, 32, 163-166.
11. KAUL, S., NAQVI, T.Z., FISHBEIN, M.C., CERCEK, B., FORRESTER, J.S., MOLLOY, M.D., BADIMON, J.J., HUTSELL, T.C. & SHAH, P.K. (1995). Profound inhibition of arterial thrombosis by a novel nitric oxide donor. J. Am. Coll. Cardiol. Issue (Feb) 34A, (Abstract).
12. KUKREJA, R.C., KONTOS, H.A., HESS, M.Z. & ELLIS, E.F. (1986). PGM synthase and lipoxygenase generate superoxide in the presence of NADH and NADPH. Circ. Res., 59, 612-619.
13. LEE, T.S., MCGREGOR, L.C., FLUHARTY, S.J. & KING, G.L. (1989). Differential regulation of protein kinase C and (Na,K)-adenosine triphosphatase activities by elevated glucose levels in retinal capillary endothelial cells. J. Clin. Invest., 83, 90-94.
14. LLEWELYN, J.G., SIMPSON, C.M.F., THOMAS, P.K., KING, R.H.M. & HAWTHORNE, J.N. (1986). Changes in sorbitol, myo-inositol and lipid inositol in dorsal root and sympathetic ganglia from streptozotocin-diabetic rats. Diabetologia, 29, 876-881.
15. MONCADA, S., PALMER, R.M.J. & HIGGS, E.A. (1991). Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol. Rev., 43, 109-142.
16. 2 by p42 microtubule-associaled protein 2 kinase and protein kinase C. J. Biol. Chem., 268, 1960-1964.
17. OSKARSSON, H.J. & HOFMEYER, T.G. (1996). Platelet-mediated endothelium-dependent vasodilation is impaired by platelets from patients with diabetes mellitus. J. Am. Coll. Cardiol., 27, 1464-1470.
18. OSKARSSON, H.J. & HOFMEYER, T.G. (1997). Diabetic human platelets release a substance which inhibits platelet-mediated vasodilation. Am. J. Phys., 273, H371-H379.
19. OSKARSSON, H.J., HOFMEYER, T.G. & KNAPP, H.R. (1997). Malondialdehyde inhibits platelet-mediated vasodilation by interfering with platelet-derived ADP. JACC, 29 (Suppl A): 304A.
20. PREISS, J., LOOMIS, C.R., BISHOP, W.R., STEIN, R., NIEDEL, J.E. & BELL, R.M. (1986), Quantitative measurement of sn-1,2-diacylglcerols present in platelets, hepatocytes, and ras-and sis-transformed normal rat kidney cells. J. Biol. Chem., 261, 8547-8600.
21. TESFAMARIAM, B., BROWN, M.L. & COHEN, R.A. (1991), Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase. C. J. din. Invest., 87, 1643-1648.
22. TESFAMARIAM, B., BROWN, M.L. & COHEN, R.A. (1992). Aldose reductase and myo-inositol in endothelial cell dysfunction caused by elevated glucose, J. Pharmacol. Exp. Ther., 263, 153-157.
23. TESFAMARIAM, B., BROWN, M.L., DEYKIN, D. & COHEN, R.A. (1990). Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta. J. Clin. Invest., 85, 929-932.
24. TESFAMARIAM, B., PALACINO, J.J., WEISBROD, R.M. & COHEN, R.A. (1993). Aldose reductase inhibition restores endothelial cell function in diabetic rabbit aorta. J. Cardiovasc. Pharmacol., 21, 205-211.
25. WILLIAMS, B. & SCHRIER, R.W. (1993). Glucose-induced protein kinase C activity regulates arachidonic acid release and eicosanoid production by cultured glomerular mesangial cells. J. Clin. Invest., 92, 2889-2896.
26. XIA, P., INOGUCHI, T., KERN, T.S., ENGERMAN, R.L., OATES, P.J. & KING, G.L. (1994), Characterization of the mechanism for the chromic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia. Diabetes, 43, 1122-1129.
27. XIA, P., KRAMER, R.M. * KING, G.L. (1995). Identification of the mechanism for the inhibition of Na + , K + -adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2. J. Clin. Invest., 96, 733-740.
28. YOREK, M.A., DUNLAP, J.A. & GINSBERG, B.H. (1987). myo-Inositol metabolism in 41A3 neuroblastoma cells: elfects of high glucose and sorbitol levels. J. Neurochem., B, 53-61.
29. ZAWALICH, W.S. & ZAWALCH, K.C. (1988). Phosphoinositide hydrolysis and insulin release from isolated perfused rat islets: studies with glucose. Diabetes, 37, 1294-1300.