Benidipine induces thermogenesis in brown adipose tissue by releasing endogenous noradrenaline: A possible mechanism for the anti-obesity effect of calcium antagonists

International Journal of Obesity

Volumn 23, Issue 3, 1999, Pages 238-245

  Zhao, J ^a   Golozoubova, V ^a   Bengtsson, T ^a   Cannon, B ^a   Nedergaard, J ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Benidipine; Brown adipose tissue; Calcium channel blockers; Heart rate; Nonshivering thermogenesis; Noradrenaline

Indexed keywords

ANTIOBESITY AGENT; BENIDIPINE; CALCIUM ANTAGONIST; NORADRENALIN; PROPRANOLOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BROWN ADIPOSE TISSUE; COLD ACCLIMATIZATION; CONTROLLED STUDY; HAMSTER; IN VITRO STUDY; IN VIVO STUDY; METABOLIC RATE; MOUSE; NONHUMAN; NORADRENALIN RELEASE; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; SYMPATHETIC NERVE; THERMOGENESIS;

AGOUTI; ANIMALIA; CRICETINAE; RODENTIA;

EID: 0033020930     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0800800     Document Type: Article

References (43)

1. 1 Scholz H. Pharmacological aspects of calcium channel blockers. Cardiovasc Drugs Ther 1997; 10: 869-872.
2. 2 Waters D. Calcium channel blockers: an evidence-based review. Can J Cardiol 1997; 13: 757-766.
3. 3 Yoshida T, Umekawa T, Wakabayashi Y, Sakame N, Kondo M. Mechanism of anti-obesity action of benidipine hydrochloride in mice. Int J Obes 1994; 18: 776-779.
4. 4 Kim JH, Mynatt RL, Moore JW, Woychik RP, Moustaid N, Zemel MB. The effect of calcium channel blockade on agouti-induced obesity. FASEB J 1996; 10: 1646-1652.
5. 5 Russel JC, Koeslag DG, Dolphin PJ, Amy RM. Prevention of myocardial lesions in JCR:LA-corpulent rats by niferdipine. Arteriosclerosis 1990; 10: 658-664.
6. cp rats with antihypertensive drugs, niferdipine and enalapril: effects on body weight, fat distribution, insulin resistance and systolic pressure. Obes Res 1993; 1: 433-442.
7. 7 Yoshioka K, Yoshida T, Kondo M. Reduced brown adipose tissue thermogenesis and metabolic rate in pre-obese mice treated with monosodium-L-glutamate. Endocrinol Jpn 1991; 38: 75-79.
8. 8 Kajita J, Kobayashi S, Yoshida T. Effect of benidipine hydrochloride on regional blood flow of the adipose tissue in anesthetized rats. Arzneim-Forsch/Drug Res 1994; 44: 297-300.
9. 9 Trayhurn P, Nicholls DG (eds). Brown Adipose Tissue. Edward Arnold: London, 1986.
10. 10 Nedergaard J, Herron D, Jacobsson A, Rehnmark S, Cannon B. Norepinephrine as a morphogen? - its unique interaction with brown adipose tissue. Int J Dev Biol 1995; 39: 827-837.
11. 11 Zhao J, Unelius L, Bengtsson T, Cannon B, Nedergaard J. Coexisting β-adrenoceptor subtypes: significance for thermogenic process in brown fat cells. Am J Physiol 1994; 267: C969-C979.
12. 1-adrenoceptor density in brown adipose tissue indicates recruitment drive in hypothyroid rats. Am J Physiol 1992; 263: E654-E662.
13. 13 Jansky L, Bartunkova R, Kockova J, Mejsnar J, Zeisberger E. Interspecies differences in cold adaptation and nonshivering thermogenesis. Fed Proc 1969; 28: 1053-1058.
14. 14 Cervinka M, Mejsnar J, Stefl B. Effect of intravenously infused noradrenaline on the cardiovascular system of cold-acclimated rats. Physiol Bohemoslov 1977; 26: 397-404.
15. 15 Hirata K, Nagasaka T. Calorigenic and cardiovascular responses to norepinephrine in anesthetized and unanesthetized control and cold-acclimated rats. Jpn J Physiol 1981; 31: 305-316.
16. 16 Wellman PJ, Marmon MM. Effects of reserpine and adrenal demedullation on brown adipose tissue thermogenesis induced by D,L-phenylpropanolamine. Res Commun Chem Pathol Pharmacol 1985; 47: 211-220.
17. 17 Arch JRS. The brown adipocyte β-adrenoceptor. Proc Nutr Soc 1989; 48: 215-223.
18. 18 Carneheim CMH, Nedergaard J, Cannon B. Cold-induced β-adrenergic recruitment of lipoprotein lipase in brown fat is due to increased transcription. Am J Physiol 1988; 254: E155-E161.
19. 19 Blatteis CM. Effect of propranolol on endotoxin-induced pyrogenesis in newborn and adult guinea pigs. J Appl Physiol 1976; 40: 35-39.
20. 20 Rothwell NJ, Stock MJ, Tedstone AE. Thermogenic effect of dihydrocodeine in the rat. Can J Physiol Pharmacol 1988; 66: 61-65.
21. 2 into the anterior hypothalamic preoptic area activates brown adipose tissue thermogenesis in the rat. Brain Res 1990; 528: 138-142.
22. 22 Chaudhry A, Vohra MM. A reserpine-like action of verapamil on cardiac sympathetic nerves. Eur J Pharmacol 1984; 97: 156-158.
23. 23 Chaudhry A, Vohra MM. Depletion of cardiac noradrenaline stores by the calcium-channel blocker D-600. Can J Physiol Pharmacol 1984; 62: 640-644.
24. 3 H]noradrenaline in rabbit aorta. Eur J Pharmacol 1984; 101: 177-183.
25. 3H)norepinephrine release. J Cardiovasc Pharmacol 1984; 6: 1060-1066.
26. 3 H]norepinephrine. J Pharmacol Exp Ther 1985; 232: 850-856.
27. 27 Wolchinsky C, Zsoter T. The effect of diltiazem on noradrenaline release. Br J Pharmacol 1985; 85: 387-393.
28. 28 Zsoter T, Wolchinsky C. The effect of nifedipine on norepinephrine release. Arch Int Pharmacodyn Ther 1986; 280: 32-44.
29. 29 Gronberg M, Terland O, Husebye ES, Flatmark T. The effect of prenylamine and organic nitrates on the bioenergetics of bovine catecholamine storage vesicles. Biochem Pharmacol 1990; 40: 351-355.
30. 30 Terland O. Catecholamine release-unpredictable side effects of calcium antagonists. Tidsskr Nor Laegeforen 1992; 15: 1952-1954.
31. +-ATPase and bioenergetics of catecholamine storage vesicles. Eur J Pharmacol 1991; 207: 37-41.
32. 14C]nitrendipine. Arzneim-Forsch/Drug Res 1988; 38: 1599-1604.
33. 33 Miltenberger RJ, Mynatt RL, Wilkinson JE, Woychik RP. The role of the agouti gene in the yellow obese syndrome. J Nutr 1997; 127: 1902S-1907S.
34. 34 Shimizu H, Shargill NS, Bray GA. Adrenalectomy and response to corticosterone and MSH in the genetically obese yellow mouse. Am J Physiol 1989; 256: R494-R500.
35. 35 Kopecky J, Clarke G, Enerback S, Spiegelman B, Kozak LP. Expression of the mitochondrial uncoupling protein gene from the aP2 promoter prevents genetic obesity. J Clin Invest 1995; 96: 2914-2923.
36. 36 Kim JH, Kiefer LL, Woychik RP, Wilkison WO, Truesdale A, Ittoop O, Willard D, J. Nichols J, Zemel MB. Agouti regulation of intracellular calcium: role of melanocortin receptors. Am J Physiol 1997; 272: E379-E384.
37. 37 Marette A, Deshaies Y, Collet AJ, Tulp O, Bukowiecki LJ. Major thermogenic defect associated with insulin resistance in brown adipose tissue of obese diabetic SHR/N-cp rats. Am J Physiol 1991; 261, E204-E213.
38. 38 Kahle EB, Butz KG, Chua SC, Kershaw EE, Leibel RL, Fenger TW, Hansen CT, Michaelis OE. The rat corpulent (cp) mutation maps to the same interval on (Pgm 1-Glut 1) rat chromosome 5 as the fatty (fa) mutation. Obes Res 1997; 5: 142-145.
39. 39 Murphy MB, Scriven AJ, Brown MJ, Causon R, Dollery CT. The effects of nifedipine and hydralazine induced hypotension on sympathetic activity. Eur J Clin Pharmacol 1982; 23: 479-482.
40. 40 Wenzel RR, Allegranza G, Binggeli C, Shaw S, Weidman P, Luscher TF, Noll G. Differential activation of cardiac and peripheral sympathetic nervous system by nifedipine: role of pharmacokinetics. J Am Coll Cardiol 1997; 29: 1607-1614.
41. 41 Barneon G, Fourcade J, Mimran A, Baldet P, Barjon P. Association pheochromocytome-pseudotumeur de graisse brune. Nouv Press Med 1975; 4: 2933-2935.
42. 42 Garruti G, Ricquier D. Analysis of uncoupling protein and its mRNA in adipose tissue deposits of adult humans. Int J Obes 1992; 16: 383-390.
43. 43 Tuck ML, Bravo EL, Krakoff LR, Friedman CP. The Modern Approach to the Treatment of Hypertension Study Group. Endocrine and renal effects of nifedipine gastrointestinal therapeutic system in patients with essential hypertension. Results of a multicenter trial. Am J Hypertens 1990; 3: 333S-341S.