An investigation into interactions between polyacrylic polymers and a non-ionic surfactant: An emulsion preformulation study

International Journal of Pharmaceutics

Volumn 184, Issue 2, 1999, Pages 207-217

  Simovic, Spomenka ^a   Tamburic, Slobodanka ^b   Milic Askrabic, Jela ^a   Rajic, Dusan ^c  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b LONDON COLLEGE OF FASHION   (United Kingdom)

^c Military Technical Institute   (Serbia)

Author keywords

Continuous shear measurements; o w emulsion; Polyacrylic polymer non ionic surfactant interaction; Polymeric emulsifier; Surface tension; Texture analysis

Indexed keywords

CARBOMER; PEMULEN TR 2; POLYACRYLIC ACID; POLYMER; POLYSORBATE 80; UNCLASSIFIED DRUG;

ARTICLE; DISPERSION; EMULSION; MOLECULAR INTERACTION; PRIORITY JOURNAL; SHEAR RATE; STRESS; SURFACE TENSION; VISCOSITY;

EID: 0033019089     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00097-6     Document Type: Article

References (24)

1. Attwood D., Florence A.T. Surfactant systems Their Chemistry, Pharmacy and Biology. 1983;364-365 Chapman and Hall, London.
2. Bobin, M.F., Michel, V., Journet, E., Martini, M.C., 1997. Study of formulation and stability of emulsions with polymeric emulsifiers. In: Proceedings 2nd World Congress on Emulsion, Bordeaux, 1, 1-1175.
3. Bremecker K.D., Koch B., Kranse W., Neuenorth L. Application-triggered drug release. Pharm. Ind. 54:1992;182-185.
4. Brisaert M., Plaizier-Vercammen J. Investigation of the emulsifying properties of Pemulen TR-1, an acrylic acid alkyl methacrylate copolymer. STP Pharma Sci. 7(6):1997;438-444.
5. Carlotti M.E., Pattarino F., Gasco M.R., Cavalli R. Use of polymeric and non- polymeric surfactants in o/w emulsion formulation. Int. J. Cosm. Sci. 17:1995;13-25.
6. Carlsson, A., 1989. Nonionic Cellulose Ethers, Interactions with Surfactants, Solubility and Other Aspects, Ph.D. Thesis, Lund University, Sweden.
7. Chen J., Dickinson E. Protein/surfactant interfacial interactions. Part 2. Electrophoretic mobility of mixed protein+surfactant systems. Colloids Surf. A. 100:1995;267-277.
8. Daniels R., Barta A. Pharmacopoeial cellulose ethers as oil-in-water emulsifiers I interfacial properties. Eur. J. Pharm. Biopharm. 40(3):1994;128-133.
9. Dittgen M., Durrani M., Lehmann K. Acrylic polymers. A review of pharmaceutical applications. STP Pharma Sci. 7(6):1997;403-437.
10. Eccleston G.M. Formulating cosmetic emulsions. Cosm. Toil. 12:1997;65-71.
11. Friberg, S.E., 1997. A few common sense observations on emulsion stability. In: Proceedings 2nd World Congress on Emulsion, Bordeaux, 4, pp. 43-64.
12. Goddard E.D. Polymer/surfactant interaction. J. Soc. Cosmet. Chem. 41:1990;23-49.
13. Hemker W.J. Universal oil-in-water polyelectrolyte emulsifiers for advanced cosmetic product formulation. SOFW. 116:1990;505-508.
14. Hüttenrauch R., Fricke S., Köhler M. Experimental confirmation of the change of water structure in the critical range of micelle formation: a new method of critical micelle concentration (CMC) determination. Pharm. Res. 11:1988;726-728.
15. Lochead R.Y, Hemker W.J, Castaneda J.Y., Garlen D. Novel cosmetic emulsions. Cosm. Toil. 101:1986;125-138.
16. Malpede, A. and Fumagali, S., 1998. Formulation of o/w emulsions with polymeric emulsifiers. In: Emulsions. Verlag fur chemische Industrie, H. Ziolkowsky GmbH, Augsburg/Germany, pp. 310-324.
17. Nystrom B., Thuresson K., Lindman B. Rheological and dynamic light-scattering studied on aqueous solutions of a hydrophobically modified nonionic cellulose ether and its unmodified analogue. Langmuir. 11:1995;1994-2002.
18. Petit F., Audeberg R., Iliopoulos I. Interactions of hydrophobically modified poly (sodium acrylate) with globular proteins. Colloid Polym. Sci. 273:1995;777-781.
19. Rimpler, S., 1996. Pharmazeutisch-technologische Charakterisierung von O/W-Emulsionen Mit Methylhydroxypropylcellulose als Polymeremulgator, Ph.D. Thesis, Fakultät für Chemie und Pharmazie der Universität Regensburg.
20. Tamburic S.and, Craig D.Q.M. A comparison of different in vitro methods for measuring mucoadhesive performance. Eur. J. Pharm. Bioph. 44:1997;159-167.
21. Tamburic S., Craig D.Q.M., Vuleta G., Milic J. An investigation into the use of thermorheology and texture analysis in the evaluation of w/o creams stabilized with a silicone emulsifier. Pharm. Dev. Technol. 1:1996;299-306.
22. Tamburic, S., Vuleta, G., Simovic, S., Milic, J., 1998. Rheological evaluation of o/w cream bases containing polymeric emulsifier. In: Emulsions. Verlag fur Chemische Industrie, H. Ziolkowsky GmbH, Augsburg/Germany, pp. 249-257.
23. Thuresson K., Lindman B. Effect of hydrophobic modification of a nonionic cellulose derivative on the interaction with surfactants. Phase behavior and association. J. Phys. Chem. 101:1998;6460-6468.
24. Winnik F.M., Regismond S.T.A. Fluorescence methods in the study of the interactions of surfactants with polymers. Colloids Surf. A. 118:1996;1-39.