Statistical analysis of adaptive response in sister chromatid exchanges in human lymphocytes after treatment with very low and extremely low doses of N-methyl-N′-nitro-N-nitrosoguanidine using a study design to control variability

Homeopathy

Volumn 88, Issue 1, 1999, Pages 7-16

  Anderson, D ^a   Edwards, A J ^a   Fisher, P ^b   Lovell, D P ^b  

^a BIBRA INTERNATIONAL   (United Kingdom)

^b UCL Hospitals NHS Trust   (United Kingdom)

Author keywords

Adaptive response; Human lymphocytes variability; Low doses; N methyl n nitro n nitroguanidine; Statistical analysis

Indexed keywords

METHYLNITRONITROSOGUANIDINE;

ADAPTATION; ARTICLE; BLOOD CULTURE; CELL DIFFERENTIATION; CHROMOSOME ABERRATION; DNA REPAIR; FIBROBLAST; LYMPHOCYTE CULTURE; QUALITY CONTROL; REPRODUCIBILITY; SISTER CHROMATID EXCHANGE; STATISTICAL ANALYSIS;

EID: 0033019038     PISSN: 14754916     EISSN: None     Source Type: Journal    
DOI: 10.1054/homp.1999.0268     Document Type: Article

References (5)

1. Samson L, Cairns J (1977). A new pathway for DNA repair in Escherichia coli. Nature; 267: 281-283.
2. 6-methylguanine-DNA methyltransferase. EMBO J; 1: 1359-1363.
3. Samson L, Schwartz JL (1980). Evidence for an adaptive DNA repair pathway in CHO and human skin Fibroblast cell lines. Nature; 287: 861-863.
4. Kaina B (1983). Studies on 'adaption' of V79 Chinese hamster cells to low doses of methylating agents. Carcinogenesis; 4: 1437-1443.
5. Karran P, Arlett CF, Broughton BC (1982). An adaptive response to the cytotoxic effects of N-methyl-N-nitrosourea is apparently absent in normal human fibroblasts. Biochemie; 64: 717-721.