Overall treatment time and the conventional arm of the CHART trial in the radiotherapy of head and neck cancer

Radiotherapy and Oncology

Volumn 50, Issue 1, 1999, Pages 25-28

  Robertson, Gerry ^a   Parmar, Mahesh ^b   Foy, Chris ^c   Griffiths, Gareth ^b   Saunders, Michele ^c   Dische, Stanley ^c  

^a BEATSON WEST OF SCOTLAND CANCER CENTRE   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

^c MOUNT VERNON HOSPITAL   (United Kingdom)

Author keywords

Head and neck; Overall time; Radiotherapy

Indexed keywords

ARTICLE; CANCER RADIOTHERAPY; CANCER SURVIVAL; FOLLOW UP; HEAD AND NECK CANCER; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; STATISTICAL ANALYSIS; TREATMENT OUTCOME;

CARCINOMA, SQUAMOUS CELL; CONFIDENCE INTERVALS; DOSE FRACTIONATION; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; MALE; ODDS RATIO; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RADIOTHERAPY DOSAGE; REMISSION INDUCTION; SURVIVAL RATE; TIME FACTORS; TREATMENT OUTCOME;

EID: 0033018990     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-8140(98)00116-9     Document Type: Article

References (16)

1. Bennett M.H., Wilson G.D., Dische S., Saunders M.I., Martindale C.A., O'Halloran A. Tumour proliferation assessed by combined histological and flow cytometric analysis: implications for therapy in squamous cell carcinoma in the head and neck. Br. J. Cancer. 65:1992;870-878.
2. Bentzen S.M., Thames H.D. Clinical evidence for tumor clonogen regeneration: interpretations of the data. Radiother. Oncol. 22:1991;161-166.
3. Dische S., Saunders M., Barrett A., et al. A randomised multicentre trial of CHART versus conventional radiotherapy in head and neck cancer. Radiother. Oncol. 44:1997;123-136.
4. Dubben H.H. Local control, TCD50 and dose-time prescription habits in radiotherapy of head and neck tumours. Radiother. Oncol. 32:1994;197-200.
5. Duncan W., Kerr G.R., Downing D. Adverse effect of treatment gaps in the outcome of radiotherapy for laryngeal cancer. Radiother. Oncol. 41:1996;203-207.
6. Fein D.A., Lee W.R., Hanlon A.L., Ridge J.A., Curran W.J., Coia L.R. Do overall treatment time, field size and treatment energy influence local control of T1-T2 squamous cell carcinomas of the glottic larynx? Int. J. Radiat. Oncol. Biol. Phys. 34:1996;823-831.
7. Fowler J.F., Lindstrom M.J. Loss of local control with prolongation in radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 23:1992;457-467.
8. Hendry J.H., Bentzen S.M., Dale R.G., et al. A modelled comparison of the effect of using different ways to compensate for missed treatment days in radiotherapy. Clin. Oncol. 8:1996;297-307.
9. Maciejewski B., Preuss-Bayer G., Trott K. The influence of the number of fractions and overall treatment time on local control and late complication rate in squamous cell carcinoma of the larynx. Int. J. Radiat. Oncol. Biol. Phys. 9:1983;321-328.
10. Overgaard O., Hjelm-Hansen M., Johansen L., Andersen A. Comparison of conventional and split-course radiotherapy as primary treatment in carcinoma of the larynx. Acta Oncol. 27:1988;147-152.
11. Overgaard O. Proceeding of ESTRO Meeting, Vienna, 1996.
12. Parmar MKB, Machin D. Survival analysis: a practical approach. Chichester, NY: Wiley, 1995.
13. Roberts S., Hendry J., Brewster A., Slevin N. The influence of radiotherapy treatment time on the control of laryngeal cancer: a direct analysis of data from two British Institute of Radiology trials to calculate the lag period and the time factor. Br. J. Radiol. 67:1994;790-794.
14. Robertson A., Robertson C., Boyle P., Symonds R., Wheldon T. The effect of differing radiotherapeutic schedules on the response of glottic carcinoma of the larynx. Eur. J. Cancer. 29A:1993;501-510.
15. Trott K. Cell repopulation and overall treatment time. Int. J. Radiat. Oncol. Biol. Phys. 19:1990;1071-1075.
16. Withers H.R., Taylor J.M.G., Maciejewski B. The hazard of accelerated tumour clonogen repopulation during radiotherapy. Acta Oncol. 27:1988;131-146.