Quantitative structure-activity relationship analysis of the inhibitory effect of flavonoids on angiotensin converting enzyme

Chinese Pharmaceutical Journal

Volumn 51, Issue 2, 1999, Pages 149-162

  Wang, Ru Bin ^a   Ren, Shi Jun ^b   Lien, Linda L ^c   Lien, Eric J ^b   Chen, Chiu Hsinng ^d   Lin, Jun Yaw ^d   Chen Liu, Karin C S ^e  

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c National Taiwan University ^*  (United States)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

ACEIs; Calculated log P; E(homo); E(lomo); Flavonoids; Parameter frame setting analysis; Quantitative structure activity relationship (QSAR)

Indexed keywords

3 HYDROXYFLAVONE; 7 HYDROXYFLAVONE; APIGENIN; APIGETRIN; CHRYSIN; CHRYSOPLENETIN; CHRYSOSPLENOL D; CIRSIMARIN; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FISETIN; FLAVONOID; KAEMPFEROL; LINARIN; LUTEOLIN 7 GLUCOSIDE; MORIN; MYRICETIN; MYRICETIN 3 RHAMNOSIDE; PATULETIN 3 2 DIRHAMNOSYL 2 (3 2 ACETYLRHAMNOSIDE); PATULETIN 3 2 RHAMNOSYL 7 2 (3 2 ACETYLRHAMNOSIDE); PATULETIN 3 2 RHAMNOSYL 7 2 (3,4 2 DIACETYLRHAMNOSIDE); PATULETIN 3,7 DIRHAMNOSIDE; PECTOLINARIN; QUERCETIN; QUERCETIN DERIVATIVE; QUERCITRIN; RHAMNUSTRIOSIDE; RUTOSIDE; UNCLASSIFIED DRUG;

ARTICLE; DIPOLE; DRUG ACTIVITY; DRUG EFFECT; ENERGY; ENZYME INHIBITION; GEOMETRY; GLYCOSYLATION; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR WEIGHT; PARTITION COEFFICIENT; PHYSICAL CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 0033018799     PISSN: 10161015     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Lien, E. J.; Gao, H.; Lien, L. L. In Search of Ideal Antihypertensive Drugs: Progress in Five Decades: Prog. Drug Res. 1994, 43, 43-86.
2. Jackson, E. K.; Garrison, J. C. Chapter 31, Renin and Angiotension in Goodman & Gilman's the Pharmacological Basis of Therapeutics, 9th ed.; Hardman, J. G., Limbird, L. E., Eds.; McGraw-Hill: New York, 1996; pp 733-808.
3. Sorensen, A. M.; Christensen, S.; Jonassen, T. E.; Andersen, D.; Petersen, J. S. Teratogenic Effects of ACE-inhibitors and Angiotension II Receptors Antagonists. Ugeskr Laeger 1998, 160, 1460-1464.
4. Das, A.; Wang, J. H.; Lien, E. J. Carcinogenicity, Mutagenicity and Cancer Preventing Activities of Flavonoids: A Structure-system-activity Relationship (SSAR) Analysis. Prog. Drug Res. 1994, 42, 133-166.
5. Van Acker, S. A. B. E.; Bast, A. Structural Aspects of Antioxidant Activity of Flavonoids in Flavonoids in Health and Disease. Rice-Evans, C. A., Packer, L., Eds; Marcel Dekker Inc.: New York, 1996; pp 221-251.
6. Chen, C. H. Inhibitory Analysis of Angiotension I Converting Enzyme by the Compounds of the Xanthones and Flavonoids in Vitro and in Vivo Studies. M. S. Thesis; National Taiwan University, Taipei, Taiwan, Republic of China, 1992.
7. Hypercube, Inc. HyperChem for Window, Version 5.0, publication HC50-00-02-00, 419 Philliph St. Waterloo, Ontario, Canada, 1996.
8. 1: a New General Purpose Quantum Mechanical Molecular Model. J. Am. Chem. Soc. 1985, 107, 3902-3909.
9. th St., Suite 204, Claremont, CA 91711, 1998.
10. Ren, S.; Das, A.; Lien, E. J. QSAR Analysis of Membrane Permeability to Organic Compounds. J. Drug Target. 1996, 4, 103-107.
11. Itokawa, H.; Totauka, N.; Nakahara, K.; Maezuru, M.; Takeya, K.; Kondo, M.; Inamats, M.; Morita, H. A Quantitative Structure-activity Relationship for Antitumor Activity of Long-chain Phenols from Ginkgo Biloba L. Chem. Pharm. Bull. 1989, 37, 1619-1621.
12. Kier, L. B. Molecular Orbital Theory in Drug Research; Ariens, E. J., Ed.; Academic Press Inc.: New York, 1971.
13. Lien, E. J. Partition Coefficients in Encyclopedia of Pharmaceutical Technology. Swarbrick, J., Boylan, J. C., Eds.; Marcel Dekker Inc.: New York, 1994; pp 293-307.