Molecular approaches to identify exposure and risk to specific environmental pollutants

Biomarkers

Volumn 4, Issue 2, 1999, Pages 93-105

  Vanden Heuvel, John P ^a   Davis II, John W ^b  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

Environmental pollutants; Gene expression; Molecular biomarkers; Polymerase chain reaction (PCR); Reporter assays

Indexed keywords

BIOLOGICAL MARKER; CHLORPHENOTANE; DIOXIN; ESTROGEN; HEAVY METAL; PHTHALIC ACID ESTER; POLYCHLORINATED BIPHENYL;

ECOTOXICOLOGY; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION; POLLUTANT; POLLUTION; POLYMERASE CHAIN REACTION; REVIEW;

EID: 0033018751     PISSN: 1354750X     EISSN: None     Source Type: Journal    
DOI: 10.1080/135475099230903     Document Type: Review

References (20)

1. ALAM, J. and COOK, J. L. 1990, Reporter genes: application to the study of mammalian gene transcription. Analytical Biochemistry, 188, 245-254.
2. ASHELY, C. M., SIMPSON, M. G., HOLDICH, D. M. and BELL, D. R. 1996, 2,3,7,8-tetrachloro-dibenzo-p-dioxin is a potent toxin and induces cytochrome P450 in the crayfish. Pacifastacus leniusculus. Aquatic Toxicology, 35, 157-169.
3. BALAGUER, P., JOYEUX, A., DENISON, M. S., VINCENT R., GILLESBY, B. E. and ZACHAREWSKI, T. 1996, Assessing the estrogenic and dioxin-like activities of chemicals and complex mixtures using in vitro recombinant receptor-reporter gene assays. Canadian Journal of Physiology and Pharmacology, 74, 216-222.
4. CHALFIE, M., Tu, Y., EUSKIRCHEN, G., WARD, W. W. and PRASHER, D. C. 1994, Green fluorescent protein as a marker for gene expression. Science, 263, 802-805.
5. DE POMERAI, D. 1996, Heat shock proteins as biomarkers of pollution. Human and Experimental Toxicology, 15, 279-285.
6. DICKERSON, R. L., HOOPER, M. J., GARD, N. W., COBB, G. P. and KENDALL, R. J. 1994, Toxicological foundations of ecological risk assessment: biomarker development and interpretation based on laboratory and wildlife species. Environmental Health Perspectives, 102, 65-69.
7. FOSSI, M. C. 1994, Nondestructive biomarkers in ecotoxicology. Environmental Health Perspectives, 102, 49-54.
8. GILLILAND, G. S., PERRIN, K. and BUNN, H. F. 1990, Competitive PCR for quantitation of mRNA. In PCR Protocols: A Guide to Methods and Applications, M. A. Innis, D. H. Gelfand, J. J. Sninsky and T. J. White, eds (San Diego, CA: Academic Press, Inc.), pp. 60-69.
9. GRANDJEAN, P., BROWN, S. S., REAYEY, P. and YOUNG, D. S. 1994, Biomarkers of chemical exposure: state of the art. Clinical Chemistry, 40, 1360-1362.
10. KAIN, S. R. and GANGULY, S. 1996, Use of fusion genes in mammalian transfection. In Current Protocols in Molecular Biology, vol. 1, F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith and K. Struhl, eds, (New York, NY: John Wiley & Sons, Inc.), pp. 9.6.1-9.6.12.
11. LINKS, J. M., KENSLER, T. W. and GROOPMAN, J. D. 1995, Biomarkers and mechanistic approaches in environmental epidemiology. Annual Reviews of Public Health, 16, 83-103.
12. MACGREGOR, J. T., FARR, S., TUCKER, J. D., HEDDLE, J. A., TICE, R. R. and TURTLETAUB, K. W. 1995, Symposia overview: new molecular endpoints and methods for routine toxicity testing. Fundamental and Applied Toxicology, 26, 156-173.
13. MATTES, W. B. 1997, The basics of the polymerase chain reaction. In PCR Protocols in Molecular Toxicology, J. P. Vanden Heuvel, ed. (Boca Raton, FL: CRC Press), pp. 1-40.
14. MCLACHLAN, J. A. 1993, Functional toxicology: a new approach to detect biologically active xenobiotics. Environmental Health Perspectives, 101, 386-387.
15. NRC 1989, Biological Markers in Reproductive Toxicology (Washington, DC: National Academy Press).
16. SEWALL, C. H., BELL, D. A., CLARK, G. C., TRITSCHER, A. M., TULLY, D. B., VANDEN HEUVEL, J. and LUCIER, G. W. 1995, Induced gene transcription: implications for biomarkers. Clinical Chemistry 41, 1829-1834.
17. TODD, M. D., LEE, M. L., WILLIAMS, J. L., NALEZNY, J. M., GEE, P., BENJAMIN, M. B. and FARR, S. B. 1995, The CAT-Tcx (L) Assay: a sensitive and specific measure of stress-induced transcription in transformed human liver cells. Fundamental and Applied Toxicology, 28, 118-128.
18. VANDEN HEUVEL, J. P. 1997, Analysis of gene expression. In PCR Protocols in Molecular Toxicology, J. P. Vanden Heuvel, ed. (Boca Raton, FL: CRC Press), pp. 41-98.
19. VANDEN HEUVEL, J. P., CLARK, G. C., THOMPSON, C. L., MCCOY, Z., MILLER, C. R., LUCIER, G. W. and BELL, D. A. 1993, CYP1A1 mRNA levels as a human exposure biomarker: use of quantitative polymerase chain reaction to measure CYP1A1 expression in human peripheral blood lymphocytes. Carcinogenesis, 14, 2003-2006.
20. VINCENT, R., GOEGAN, P., JOHNSON, G., BROOK, J. R., KUMARATHASAN, P., BOUTHILLER, L. and BURNETT, R. T. 1997, Regulation of promoter-CAT stress genes in HEPG2 cells by suspensions of particles from ambient air. Fundamental and Applied Toxicology, 39, 18-32.