Normal T-helper 1/T-helper 2 balance in peripheral blood of coeliac disease patients

Scandinavian Journal of Immunology

Volumn 49, Issue 2, 1999, Pages 197-202

  Kerttula, T O ^a   Collin, P ^a   Maki M ^a,b   Hurme, M ^a,c  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF TAMPERE   (Finland)

^c TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4;

ADULT; AGED; ARTICLE; CELIAC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GLUTEN FREE DIET; HELPER CELL; HUMAN; HUMAN CELL; PATHOGENESIS; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ADOLESCENT; ADULT; AGED; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; HUMANS; INTERFERON TYPE II; INTERLEUKIN-2; INTERLEUKIN-4; INTRACELLULAR FLUID; JEJUNAL DISEASES; MIDDLE AGED; TH1 CELLS; TH2 CELLS;

EID: 0033018517     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1999.00478.x     Document Type: Article

References (34)

1. Mäki M, Collin P. Coeliac disease. Lancet 1997;349:1755-9.
2. Kagnoff MF. Genetic basis of coeliac disease: role of HLA genes. In: Marsh M, ed. Coeliac Disease. Oxford: Blackwell Scientific Publications, 1992:215-38.
3. Lundin KEA, Scott H, Hansen T et al. Gliadin-specific, HLA-DQ (α1*0501,β1*0201) restricted T cells isolated from small intestinal mucosa of celiac disease patients. J Exp Med 1993;178:187-96.
4. Lundin KEA, Scott H, Fausa O, Thorsby E, Sollid LM. T cells from the small intestinal mucosa of a DR4, DR7/DR4, DQ8 celiac disease patient preferentially recognize gliadin when presented by DQ8. Human Immunol 1994;41:285-91.
5. Mosmann TR, Coffman RL. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145-73.
6. Abehsira-Amar O, Gibert M, Joliy M, Thèze J, Jankovic DLJ. IL-4 plays a dominant role in the differential development of Th0 into Th1 and Th2 cells. J Immunol 1992;148:3820-9.
7. Mosmann TR, Sad S. The expanding universe of T-cell subsets. Th1, Th2 and more. Immunol Today 1996;17:138-46.
8. Shehadeh NN, LaRosa F, Lafferty KJ. Altered cytokine activity in adjuvant inhibition of autoimmune diabetes. J Autoimmun 1993;6:291-300.
9. Matyniak J, Reiner SL. T helper phenotype and genetic susceptibility in experimental Lyme disease. J Exp Med 1995;181:1251-4.
10. Racke MK, Bonomo A, Scott DE et al. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J Exp Med 1961;1994:180-6.
11. Kuchroo VK, Das MP, Brown JA et al. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 1995;80:707-18.
12. Correale J, Gilmore W, McMillan M et al. Patterns of cytokine secretion by autoreactive proteolipid protein-specific T cell clones during the course of multiple sclerosis. J Immunol 1995;154:2959-68.
13. Dolhain RJEM, van der Heiden A, ter Haar NT, Breedveld FC, Miltenburg AMM. Shift toward T lymphocytes with a T helper 1 cytokine-secretion profile in the joints of patients with rheumatoid arthritis. Arthritis Rheumatism 1996;39:1961-9.
14. Chowers Y, Marsh MN, de Grandpre L, Nyberg A, Theofilopoulos AN, Kagnoff MF. Increased proinflammatory cytokine gene expression in the colonic mucosa of coeliac disease patients in the early period after gluten challenge. Clin Exp Immunol 1997;107:141-7.
15. Kontakou M, Przemioslo RT, Sturgess RP, Limb AG, Ciclitira PJ. Expression of tumour necrosis factor-α, interleukin-6, and interleukin-2 mRNA in the jejunum of patients with coeliac disease. Scand J Gastroenterol 1995;30:456-63.
16. Sturgess RP, Hooper LB, Spencer J, Hung C-H, Nelufer JM, Ciclitira PJ. Effects of interferon-γ and tumour necrosis factor-α on epithelial HLA class-II expression on jejunal mucosal biopsy specimens cultured in vitro. Scand J Gastroenterol 1992;27:907-11.
17. Kontakou M, Sturgess RP, Przemioslo RT, Limb GA, Nelufer JM, Ciclitira PJ. Detection of interferon gamma mRNA in the mucosa of patients with coeliac disease by in situ hybridisation. Gut 1994;35:1037-41.
18. Przemioslo RT, Lundin KEA, Sollid LM, Nelufer J, Ciclitira PJ. Histological changes in small bowel mucosa induced by gliadin sensitive T lymphocytes can be blocked by anti-interferon γ antibody. Gut 1995;36:874-9.
19. Nilsen EM, Lundin KEA, KrajFi Scott H, Sollid LM, Brandtzaeg P. Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon. Gut 1995;37:766-76.
20. Beckett CG, Dell'Olio D, Kontakou M, Przemioslo RT, Rosen-Bronson S, Ciclitira PJ. Analysis of interleukin-4 and interleukin-10 and their association with the lymphocyte infiltrate in the small intestine of patients with coeliac disease. Gut 1996;39:818-23.
21. Lambrechts A, Carol M, van Gossum A, Laberenne JE, Colombel JF, Mascart F. Deficit in spontaneous IL-4 secretion by intra-epithelial (IEL) and lamina propria (LPL); lymphocytes from adult coeliac patients. In: Collin P, Mäki M, eds. All on Coeliac Disease, Free Paper Abstracts. Seventh International Symposium On Coeliae Disease. Vammala: Lege Artis Oy. 1996:80.
22. Nilsen EM, Gjertsen HA, Jensen K, Brandtzaeg P, Lundi KEA. Gluten activation of peripheral blood T cells induces a Th0-like cytokine pattern in both coeliac patients and controls. Clin Exp Immunol 1996;103:295-303.
23. Haltensen TS, Farstad IN, Scott H, Fausa O, Brandtzaeg P. Intraepithelial TcRα/β+ lymphocytes express CD45RO more often than their TcRγ/δ counterparts in coeliac disease. Immunology 1990;71:460-6.
24. Kerttula TO, Hällström O, Mäki M. Phenotypical characterization of peripheral blood T cells in patients with coeliac disease: elevation of antigen-primed CD45RO+ T lymphocytes, Immunology 1995;86:104-9.
25. Lerner A, Karban A, Lahat N, Gerstein R, Kinarty A, Shapiro S. Th1/Th2 cytokines in coeliac disease. J Pediatr Gastroenterol Nutr 1997;24:466.
26. Reunala T, Kosnai I, Karpati S, Kuitunen P, Török E, Savilahti E. Dermatitis herpetiformis: jejunal findings and skin response to gluten-free diet. Arch Dis Child 1984;59:517-22.
27. Aine L, Mäki M, Collin P, Keyriläinen O. Dental enamel defects in celiac disease. J Oral Pathol Med 1990;19:241-5.
28. Crabtree JE, Heatley RV, Juby LD, Howdle PD, Losowsky MS. Serum interleukin-2-receptor in coeliac disease: response to treatment and gluten challenge. Clin Exp Immunol 1989; 77: 345-8.
29. Penedo-Pita M, Peteiro-Cartelle J. Increased serum levels of interleukin-2 and soluble interleukin-2 receptor in celiac disease. J Pediatr Gastroenterol Nutr 1991;12:56-60.
30. Hansson T, Dannæus A, Rönnelid J, Klareskog L. IFN-gamma and IL-4 producing cells in blood of children with coeliac disease. In: Collin P, Mäki M, eds. All on Coeliac Disease, Free Paper Abstracts. Seventh International Symposium On Coeliac Disease. Vammala: Lege Artis Oy. 1996:82.
31. Gjertsen HA, Sollid LM, Ek J, Thorsby E, Lundin KEA. T cells from the peripheral blood of coeliac disease patients recognize gluten antigens when presented by HLA-DR, -DQ, or -DP molecules. Scand J Immunol 1994;39:567-74.
32. Esnault S, Benbernou N, Lavaud F, Shin HC, Potron G, Guenounou M. Differential spontaneous expression of mRNA for IL-4, IL-10, IL-13, IL-2 and interferon-gamma (IFN-γ) in peripheral blood mononuclear cells (PBMC) from atopic patients. Clin Exp Immunol 1996;103:111-8.
33. Ward BJ, Griffin DE. Changes in cytokine production afte measles virus vaccination: predominant production of IL-4 suggests induction of a Th2 response. Clin Immunol Immunopathol 1993;67:171-7.
34. Maggi E, Biswas P, del Prete G et al. Accumulation of Th-2-like helper T cells in the conjunctiva of patients with vernal conjunctivitis. J Immunol 1991;146:1169-74.