Action of the brain stem saccade generator during horizontal gaze shifts. I. Discharge patterns of omnidirectional pause neurons

Journal of Neurophysiology

Volumn 81, Issue 3, 1999, Pages 1284-1295

  Phillips, James O ^a   Ling, Leo ^a   Fuchs, Albert F ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; GAZE; HEAD MOVEMENT; MOTONEURON; NEUROTRANSMISSION; PRIORITY JOURNAL; SACCADIC EYE MOVEMENT; VESTIBULOOCULAR REFLEX;

EID: 0033017588     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1999.81.3.1284     Document Type: Article

References (43)

1. BUTTNER-ENNEVER, J. A., COHEN, B., PAUSE, M., AND FRIES, W. Raphe nucleus of the pons containing omnipause neurons of the oculomotor system in the monkey, and its homologue in man. J. Comp. Neurol. 267: 307-321, 1988.
2. COBLE, E. T., LING, L., PHILLIPS, J. O., AND FUCHS, A. F. The role of omnipause neurons during gaze shifts. In: Visual and Oculomotor Functions: Advances in Eye Movement Research, edited by G. d'Ydewalle and J. Van Rensbergen. Amsterdam: Elsevier/North-Holland, 1994, p. 285-293.
3. COHEN, B. AND HENN, V. Unit activity in the pontine reticular formation associated with eye movements. Brain Res. 46: 403-410, 1972.
4. CURTHOYS, I. S., MARKHAM, C. H., AND FURUYA, N. Direct projection of pause neurons to nystagmus-related excitatory burst neurons in the cat pontine reticular formation. Exp. Neurol. 83: 414-422, 1984.
5. FREEDMAN, E. G. AND SPARKS, D. L. Eye-head coordination during head-unrestrained gaze shifts in rhesus monkeys. J. Neurophysiol. 77: 2328-2348, 1997.
6. FUCHS, A. F., LING, L., KANEKO, C.R.S., KING, W. M., AND USHER, S. D. The time of the response of brainstem omnipause neurons relative to saccadic eye movements in rhesus monkeys. Soc. Neurosci. Abstr. 17: 462, 1991.
7. FUCHS, A. F., ROBINSON, F. R., AND STRAUBE, A. Participation of the caudal fastigial nucleus in smooth-pursuit eye movements. I. Neuronal activity. J. Neurophysiol. 72: 2714-2728, 1994.
8. FURUYA, N. AND MARKHAM, C. H. Direct inhibitory synaptic linkage of pause neurons with burst inhibitory neurons. Brain Res. 245: 139-143, 1982.
9. GALIANA, H. L. AND GUITTON, D. Central organization and modeling of eye-head coordination during orienting gaze shifts. Ann. NY Acad. Sci. 656: 452-470, 1992.
10. GUITTON, D. Eye-head coordination in gaze control. In: Control of Head Movement, edited by B. W. Peterson and F. J. Richmond. New York: Oxford Univ. Press, 1988, p. 196-207.
11. GUITTON, D., DOUGLAS, R. M., AND VOLLE, M. Eye head coordination in cats. J. Neurophysiol. 52: 1030-1049, 1984.
12. GUITTON, D., MUNOZ, D. P., AND GALIANA, H. L. Gaze control in the cat: studies and modeling of the coupling between orienting eye and head movements in different behavioral tasks. J. Neurophysiol. 64: 509-531, 1990.
13. GUITTON, D. AND VOLLE, M. Gaze control in humans: eye-head coordination during orienting movements to targets within and beyond the oculomotor range. J. Neurophysiol. 58: 427-458, 1987.
14. HIKOSAKA, O., IGUSA, Y., NAKAO, S., AND SHIMAZU, H. Direct inhibitory synaptic linkage of pontomedullary reticular burst neurons with abducens motoneurons in the cat. Exp. Brain Res. 33: 337-352, 1978.
15. HORN, A.K.E., BÜTTNER-ENNEVER, J. A., WAHLE, P., AND REICHENBERGER, I. Neurotransmitter profile of saccadic omnipause neurons in nucleus raphe interpositus. J. Neurosci. 14: 2032-2046, 1994.
16. KELLER, E. L. Participation of the medial pontine reticular formation in eye movement generation in monkey. J. Neurophysiol. 37: 316-332, 1974.
17. KING, W. M. Quantitative Analysis of the Activity of Neurons in the Accessory Oculomotor Nuclei and the Mesencephalic Reticular Formation of Alert Monkeys in Relation to Vertical Eye Movements Induced by Visual and Vestibular Stimulation (PhD thesis). Seattle, WA: Univ. of Washington, 1976.
18. LANGER, T. P. AND KANEKO, C.R.S. Brainstem afferents to the oculomotor omnipause neurons in monkey. J. Comp. Neurol. 295: 413-427, 1990.
19. LAURUTIS, V. P. AND ROBINSON, D. A. The vestibulo-ocular reflex during human saccadic eye movement. J. Physiol. (Lond.) 373: 209-233, 1986.
20. LEFEVRE, P., MISSAL, M., AND GALIANA, H. L. Modeling slow correcting gaze movements. J. Vestib. Res. 4: 371-381, 1994.
21. LING, L., PHILLIPS, J., AND FUCHS, A. F. Transient responses of primate pontine neurons for visually targeted eye and head movements. Soc. Neurosci. Abstr. 16: 904, 1990.
22. LUSCHEI, E. S. AND FUCHS, A. F. Activity of brain stem neurons during eye movements of alert monkeys. J. Neurophysiol. 35: 445-461, 1972.
23. MISSAL, M., CROMMELINCK, M., ROUCOUX, A., AND DECOSTRE, M. Slow correcting eye movements of head fixed trained cats toward stationary targets. Exp. Brain Res. 96: 65-76, 1993.
24. MISSAL, M., LEFEVRE, P., DELINTE, A., CROMMELINCK, M., AND ROUCOUX, A. Smooth eye movements evoked by electrical stimulation of the cat's superior colliculus. Exp. Brain Res. 107: 382-390, 1996.
25. MOSCHOVAKIS, A. K., SCUDDER, C. A., AND HIGHSTEIN, S. M. The microscopic anatomy and physiology of the mammalian saccadic system. Prog. Neurobiol. 50: 133-254, 1996.
26. OLIVIER, E., GRANTYN, A., CHAT, M., AND BERTHOZ, A. The control of slow orienting eye movements by tectoreticulospinal neurons in the cat: behavior, discharge patterns, and underlying connections. Exp. Brain Res. 93: 435-449, 1993.
27. PARE, M. AND GUITTON, D. Gaze related activity of brainstem omnipause neurons recorded in the alert head-free cat. Soc. Neurosci. Abstr. 15: 99.7, 1989.
28. PARE, M. AND GUITTON, D. Gaze related activity of brainstem omnipause neurons during combined eye-head gaze shifts in the alert cat. Exp. Brain Res. 83: 210-214, 1990.
29. PARE, M. AND GUITTON, D. Brain stem omnipause neurons and the control of combined eye-head saccades in the alert cat. J. Neurophysiol. 79: 3060-3076, 1998.
30. PETIT, J., KLAM, F., GRANTYN, A., AND BERTHOZ, A. Activity of cat omnipause neurons during tracking of moving targets. Soc. Neurosci. Abstr. 23: 2368, 1997.
31. PHILLIPS, J. O. Brainstem Control of Coordinated Eye and Head Movement: Neuroanatomical, Behavioral and Neurophysiological Studies of the Control of Gaze Behavior in the Monkey (PhD thesis). Seattle, WA: Univ. of Washington, 1993.
32. PHILLIPS, J. O., LING, L., AND FUCHS, A. F. Head free primate gaze shifts in response to double target steps. Soc. Neurosci. Abstr. 21: 1197, 1995a.
33. PHILLIPS, J. O., LING, L., FUCHS, A. F., SIEBOLD, C., AND PLORDE, J. J. Rapid horizontal gaze movement in the monkey. J. Neurophysiol. 73: 1632-1652, 1995b.
34. PHILLIPS, J. O., LING, L., IWAMOTO, Y., SIEBOLD, C., NEWLANDS, S., AND FUCHS, A. F. Head-related discharge in the primate brainstem during head-free gaze shifts. J. Vestib. Res. 6: 12, 1996a.
35. PHILLIPS, J. O., LING, L., SIEBOLD, C., FUCHS, A. F. Behavior of primate vestibulo-ocular reflex neurons during head free gaze shifts. Ann. NY Acad. Sci. 781: 276-291, 1996b.
36. RON, S., BERTHOZ, A., AND GUR, S. Saccade-vestibulo-ocular reflex co-operation and eye-head uncoupling during orientation to flashed target. J. Physiol. (Lond.) 464: 595-611, 1993.
37. SCUDDER, C. A. AND FUCHS, A. F. Physiological and behavioral identification of vestibular nucleus neurons mediating the horizontal vestibulo-ocular reflex in trained rhesus monkeys. J. Neurophysiol. 68: 244-264, 1992.
38. SCUDDER, C. A., FUCHS, A. F., AND LANGER, T. P. Characteristics and functional identification of saccadic inhibitory burst neurons in the alert monkey. J. Neurophysiol. 59: 1430-1454, 1988.
39. STRASSMAN, A., HIGHSTEIN, S. M., AND MCCREA, R. A. Anatomy and physiology of saccadic burst neurons in the alert squirrel monkey. II. Inhibitory burst neurons. J. Comp. Neurol. 249: 358-380, 1986.
40. TOMLINSON, R. D. Combined eye-head gaze shifts in the primate. III. Contributions to the accuracy of gaze saccades. J. Neurophysiol. 64: 1873-1891, 1990
41. TOMLINSON, R. D. AND BAHRA, P. S. Combined eye-head gaze shifts in the primate. I. Metrics. J. Neurophysiol. 56: 1542-1557, 1986a.
42. TOMLINSON, R. D. AND BAHRA, P. S. Combined eye-head gaze shifts in the primate. II. Interactions between saccades and the vestibulo-ocular reflex. J. Neurophysiol. 56: 1558-1570, 1986b.
43. YOSHIDA, K., MCCREA, R. A., BERTHOZ, A., AND VIDAL, P. P. Morphological and physiological characteristics of inhibitory burst neurons controlling horizontal rapid eye movements in the alert cat. J. Neurophysiol. 48: 761-784, 1982.